Abstract
Obesity is associated with chronic low-grade systemic inflammation. Bariatric surgery has been shown to reduce this inflammation. Here, the effect of a nonsurgical bariatric technique, the duodenal-jejunal bypass liner (DJBL), on systemic inflammation was investigated. Seventeen obese patients with type 2 diabetes were treated with the DJBL for 6 months. Plasma C-reactive protein (CRP), myeloperoxidase (MPO), interleukin-6 (IL-6), and tumor necrosis factor alpha (TNF-alpha) were determined prior to and during DJBL treatment. Three months after initiation of DJBL treatment, TNF-alpha levels had increased from 1.8 +/- 0.1 to 2.1 +/- 0.1 pg/mL, whereas IL-6 increased from 2.7 +/- 0.3 to 4.0 +/- 0.5 pg/mL (both p <0.05). CRP and MPO also increased, though the differences were not significant. After 6 months, the levels of all parameters were similar to baseline levels (CRP, 4.2 +/- 0.6 mg/L; TNF-alpha, 2.0 +/- 0.1 pg/mL; IL-6, 3.5 +/- 0.5 pg/mL; MPO, 53.6 +/- ng/mL; all p = ns compared to baseline). In the current study, 6 months of endoscopic DJBL treatment did not lead to decreased systemic inflammation.
Original language | English |
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Pages (from-to) | 337-341 |
Number of pages | 5 |
Journal | Obesity Surgery |
Volume | 24 |
Issue number | 2 |
DOIs | |
Publication status | Published - Feb 2014 |
Keywords
- Bariatric surgery
- Inflammation
- Duodenal-jejunal exclusion
- WEIGHT-LOSS
- BARIATRIC SURGERY
- INSULIN-RESISTANCE
- MORBID-OBESITY
- METAANALYSIS
- PROTEINS
- MARKERS
- DISEASE
- LEPTIN