Significantly higher rates of multiple and proximally located adenomas among patients with diabetes mellitus: A cross-sectional population-based study

Sander de Kort; Marielle W. E. Bouwens; Matty P. Weijenberg; Maryska L. G. Janssen-Heijnen; Adriaan P. de Bruine; Robert Riedl; Ad A. M. Masclee; Silvia Sanduleanu

doi:10.1177/2050640616664271

Significantly higher rates of multiple and proximally located adenomas among patients with diabetes mellitus: A cross-sectional population-based study

Sander de Kort, Marielle W. E. Bouwens, Matty P. Weijenberg, Maryska L. G. Janssen-Heijnen, Adriaan P. de Bruine, Robert Riedl, Ad A. M. Masclee, Silvia Sanduleanu^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Background: Diabetes mellitus (DM) is associated with a greater risk for colorectal cancer (CRC).

Objective: The objective of this article is to examine the endoscopic phenotype and histopathology of colorectal polyps in patients with vs without DM.

Methods We conducted a cross-sectional study of patients who underwent colonoscopy at our university hospital and who completed a questionnaire. We collected endoscopy and histopathology data regarding colorectal adenomas and serrated polyps. Cox regression analyses were used to estimate adjusted prevalence ratios (PRs).

Results: We examined a total of 3654 patients (mean age (SD): 62 (12) years, 47% males). Of them, 360 (9.9%) had DM. Overall, the prevalence of colorectal adenomas (42% vs 32%, p= 3) adenomas (12% vs 7%, p=0.01) and proximal adenomas (30% vs 19%, p

Conclusion: Patients with DM harbor more frequently multiple and proximal adenomas than those without DM. Close colonoscopic surveillance of DM patients is important to maximize the effectiveness of colonoscopic CRC prevention.

Original language	English
Pages (from-to)	415-423
Number of pages	9
Journal	United European Gastroenterology Journal
Volume	5
Issue number	3
DOIs	https://doi.org/10.1177/2050640616664271
Publication status	Published - Apr 2017

Keywords

Diabetes mellitus
colorectal cancer
colorectal neoplasm
epidemiology
colonoscopy
prevention
COLORECTAL-CANCER RISK
HYPERPLASTIC POLYPS
QUALITY INDICATORS
PLASMA-GLUCOSE
COLONOSCOPY
PREVALENCE
INSULIN
NEOPLASIA
METAANALYSIS
INDIVIDUALS

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10.1177/2050640616664271

Cite this

de Kort, S., Bouwens, M. W. E., Weijenberg, M. P., Janssen-Heijnen, M. L. G., de Bruine, A. P., Riedl, R., Masclee, A. A. M., & Sanduleanu, S. (2017). Significantly higher rates of multiple and proximally located adenomas among patients with diabetes mellitus: A cross-sectional population-based study. United European Gastroenterology Journal, 5(3), 415-423. https://doi.org/10.1177/2050640616664271

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title = "Significantly higher rates of multiple and proximally located adenomas among patients with diabetes mellitus: A cross-sectional population-based study",

abstract = "Background: Diabetes mellitus (DM) is associated with a greater risk for colorectal cancer (CRC).Objective: The objective of this article is to examine the endoscopic phenotype and histopathology of colorectal polyps in patients with vs without DM.Methods We conducted a cross-sectional study of patients who underwent colonoscopy at our university hospital and who completed a questionnaire. We collected endoscopy and histopathology data regarding colorectal adenomas and serrated polyps. Cox regression analyses were used to estimate adjusted prevalence ratios (PRs).Results: We examined a total of 3654 patients (mean age (SD): 62 (12) years, 47% males). Of them, 360 (9.9%) had DM. Overall, the prevalence of colorectal adenomas (42% vs 32%, p= 3) adenomas (12% vs 7%, p=0.01) and proximal adenomas (30% vs 19%, pConclusion: Patients with DM harbor more frequently multiple and proximal adenomas than those without DM. Close colonoscopic surveillance of DM patients is important to maximize the effectiveness of colonoscopic CRC prevention.",

keywords = "Diabetes mellitus, colorectal cancer, colorectal neoplasm, epidemiology, colonoscopy, prevention, COLORECTAL-CANCER RISK, HYPERPLASTIC POLYPS, QUALITY INDICATORS, PLASMA-GLUCOSE, COLONOSCOPY, PREVALENCE, INSULIN, NEOPLASIA, METAANALYSIS, INDIVIDUALS",

author = "{de Kort}, Sander and Bouwens, {Marielle W. E.} and Weijenberg, {Matty P.} and Janssen-Heijnen, {Maryska L. G.} and {de Bruine}, {Adriaan P.} and Robert Riedl and Masclee, {Ad A. M.} and Silvia Sanduleanu",

year = "2017",

month = apr,

doi = "10.1177/2050640616664271",

language = "English",

volume = "5",

pages = "415--423",

journal = "United European Gastroenterology Journal",

issn = "2050-6406",

publisher = "SAGE Publications Inc.",

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de Kort, S, Bouwens, MWE, Weijenberg, MP , Janssen-Heijnen, MLG, de Bruine, AP, Riedl, R, Masclee, AAM & Sanduleanu, S 2017, 'Significantly higher rates of multiple and proximally located adenomas among patients with diabetes mellitus: A cross-sectional population-based study', United European Gastroenterology Journal, vol. 5, no. 3, pp. 415-423. https://doi.org/10.1177/2050640616664271

Significantly higher rates of multiple and proximally located adenomas among patients with diabetes mellitus: A cross-sectional population-based study. / de Kort, Sander; Bouwens, Marielle W. E.; Weijenberg, Matty P. et al.
In: United European Gastroenterology Journal, Vol. 5, No. 3, 04.2017, p. 415-423.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Significantly higher rates of multiple and proximally located adenomas among patients with diabetes mellitus

T2 - A cross-sectional population-based study

AU - de Kort, Sander

AU - Bouwens, Marielle W. E.

AU - Weijenberg, Matty P.

AU - Janssen-Heijnen, Maryska L. G.

AU - de Bruine, Adriaan P.

AU - Riedl, Robert

AU - Masclee, Ad A. M.

AU - Sanduleanu, Silvia

PY - 2017/4

Y1 - 2017/4

N2 - Background: Diabetes mellitus (DM) is associated with a greater risk for colorectal cancer (CRC).Objective: The objective of this article is to examine the endoscopic phenotype and histopathology of colorectal polyps in patients with vs without DM.Methods We conducted a cross-sectional study of patients who underwent colonoscopy at our university hospital and who completed a questionnaire. We collected endoscopy and histopathology data regarding colorectal adenomas and serrated polyps. Cox regression analyses were used to estimate adjusted prevalence ratios (PRs).Results: We examined a total of 3654 patients (mean age (SD): 62 (12) years, 47% males). Of them, 360 (9.9%) had DM. Overall, the prevalence of colorectal adenomas (42% vs 32%, p= 3) adenomas (12% vs 7%, p=0.01) and proximal adenomas (30% vs 19%, pConclusion: Patients with DM harbor more frequently multiple and proximal adenomas than those without DM. Close colonoscopic surveillance of DM patients is important to maximize the effectiveness of colonoscopic CRC prevention.

AB - Background: Diabetes mellitus (DM) is associated with a greater risk for colorectal cancer (CRC).Objective: The objective of this article is to examine the endoscopic phenotype and histopathology of colorectal polyps in patients with vs without DM.Methods We conducted a cross-sectional study of patients who underwent colonoscopy at our university hospital and who completed a questionnaire. We collected endoscopy and histopathology data regarding colorectal adenomas and serrated polyps. Cox regression analyses were used to estimate adjusted prevalence ratios (PRs).Results: We examined a total of 3654 patients (mean age (SD): 62 (12) years, 47% males). Of them, 360 (9.9%) had DM. Overall, the prevalence of colorectal adenomas (42% vs 32%, p= 3) adenomas (12% vs 7%, p=0.01) and proximal adenomas (30% vs 19%, pConclusion: Patients with DM harbor more frequently multiple and proximal adenomas than those without DM. Close colonoscopic surveillance of DM patients is important to maximize the effectiveness of colonoscopic CRC prevention.

KW - Diabetes mellitus

KW - colorectal cancer

KW - colorectal neoplasm

KW - epidemiology

KW - colonoscopy

KW - prevention

KW - COLORECTAL-CANCER RISK

KW - HYPERPLASTIC POLYPS

KW - QUALITY INDICATORS

KW - PLASMA-GLUCOSE

KW - COLONOSCOPY

KW - PREVALENCE

KW - INSULIN

KW - NEOPLASIA

KW - METAANALYSIS

KW - INDIVIDUALS

U2 - 10.1177/2050640616664271

DO - 10.1177/2050640616664271

M3 - Article

SN - 2050-6406

VL - 5

SP - 415

EP - 423

JO - United European Gastroenterology Journal

JF - United European Gastroenterology Journal

IS - 3

ER -