Shorter cryoballoon applications times do effect efficacy but result in less phrenic nerve injury: Results of the randomized 123 study

Marleen M. D. Molenaar; Carl C. Timmermans; Tim Hesselink; Marcoen F. Scholten; Rachel M. A. ter Bekke; Justin G. L. M. Luermans; Marjolein Brusse-Keizer; Karin Kraaier; Bernard ten Haken; Jan G. Grandjean; Kevin Vernooy; Jurren M. van Opstal

doi:10.1111/pace.13626

Shorter cryoballoon applications times do effect efficacy but result in less phrenic nerve injury: Results of the randomized 123 study

Marleen M. D. Molenaar^*, Carl C. Timmermans, Tim Hesselink, Marcoen F. Scholten, Rachel M. A. ter Bekke, Justin G. L. M. Luermans, Marjolein Brusse-Keizer, Karin Kraaier, Bernard ten Haken, Jan G. Grandjean, Kevin Vernooy, Jurren M. van Opstal

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Background The second-generation cryoballoon significantly improves outcome of pulmonary vein isolation (PVI) but may cause more complications than the first generation. Currently, no consensus regarding optimal cryoballoon application time exists. The 123-study aimed to assess the minimal cryoballoon application duration necessary to achieve PVI (primary endpoint) and the effect of application duration on prevention of phrenic nerve injury (PNI). Methods Patients

Original language	English
Pages (from-to)	508-514
Number of pages	7
Journal	Pacing and Clinical Electrophysiology
Volume	42
Issue number	5
DOIs	https://doi.org/10.1111/pace.13626
Publication status	Published - May 2019

Keywords

atrial fibrillation
cryoballoon
phrenic nerve injury
pulmonary vein isolation
safety
PULMONARY VEIN ISOLATION
PAROXYSMAL ATRIAL-FIBRILLATION
28 MM CRYOBALLOON
2ND-GENERATION CRYOBALLOON
CLINICAL SUCCESS
3-MINUTE FREEZE
BONUS-FREEZE
ABLATION
PALSY
CRYOABLATION

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Cite this

Molenaar, M. M. D., Timmermans, C. C., Hesselink, T., Scholten, M. F., ter Bekke, R. M. A., Luermans, J. G. L. M., Brusse-Keizer, M., Kraaier, K., ten Haken, B., Grandjean, J. G., Vernooy, K., & van Opstal, J. M. (2019). Shorter cryoballoon applications times do effect efficacy but result in less phrenic nerve injury: Results of the randomized 123 study. Pacing and Clinical Electrophysiology, 42(5), 508-514. https://doi.org/10.1111/pace.13626

@article{09aa8671a9e142d2944b7a625cd9a760,

title = "Shorter cryoballoon applications times do effect efficacy but result in less phrenic nerve injury: Results of the randomized 123 study",

abstract = "Background The second-generation cryoballoon significantly improves outcome of pulmonary vein isolation (PVI) but may cause more complications than the first generation. Currently, no consensus regarding optimal cryoballoon application time exists. The 123-study aimed to assess the minimal cryoballoon application duration necessary to achieve PVI (primary endpoint) and the effect of application duration on prevention of phrenic nerve injury (PNI). Methods Patients",

keywords = "atrial fibrillation, cryoballoon, phrenic nerve injury, pulmonary vein isolation, safety, PULMONARY VEIN ISOLATION, PAROXYSMAL ATRIAL-FIBRILLATION, 28 MM CRYOBALLOON, 2ND-GENERATION CRYOBALLOON, CLINICAL SUCCESS, 3-MINUTE FREEZE, BONUS-FREEZE, ABLATION, PALSY, CRYOABLATION",

author = "Molenaar, {Marleen M. D.} and Timmermans, {Carl C.} and Tim Hesselink and Scholten, {Marcoen F.} and {ter Bekke}, {Rachel M. A.} and Luermans, {Justin G. L. M.} and Marjolein Brusse-Keizer and Karin Kraaier and {ten Haken}, Bernard and Grandjean, {Jan G.} and Kevin Vernooy and {van Opstal}, {Jurren M.}",

note = "Funding Information: This study was funded in part by Medtronic Inc. Publisher Copyright: {\textcopyright} 2019 The Authors. Pacing and Clinical Electrophysiology published by Wiley Periodicals, Inc.",

year = "2019",

month = may,

doi = "10.1111/pace.13626",

language = "English",

volume = "42",

pages = "508--514",

journal = "Pacing and Clinical Electrophysiology",

issn = "0147-8389",

publisher = "Wiley",

number = "5",

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Molenaar, MMD, Timmermans, CC, Hesselink, T, Scholten, MF, ter Bekke, RMA , Luermans, JGLM, Brusse-Keizer, M, Kraaier, K, ten Haken, B, Grandjean, JG, Vernooy, K & van Opstal, JM 2019, 'Shorter cryoballoon applications times do effect efficacy but result in less phrenic nerve injury: Results of the randomized 123 study', Pacing and Clinical Electrophysiology, vol. 42, no. 5, pp. 508-514. https://doi.org/10.1111/pace.13626

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AU - Molenaar, Marleen M. D.

AU - Timmermans, Carl C.

AU - Hesselink, Tim

AU - Scholten, Marcoen F.

AU - ter Bekke, Rachel M. A.

AU - Luermans, Justin G. L. M.

AU - Brusse-Keizer, Marjolein

AU - Kraaier, Karin

AU - ten Haken, Bernard

AU - Grandjean, Jan G.

AU - Vernooy, Kevin

AU - van Opstal, Jurren M.

PY - 2019/5

Y1 - 2019/5

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AB - Background The second-generation cryoballoon significantly improves outcome of pulmonary vein isolation (PVI) but may cause more complications than the first generation. Currently, no consensus regarding optimal cryoballoon application time exists. The 123-study aimed to assess the minimal cryoballoon application duration necessary to achieve PVI (primary endpoint) and the effect of application duration on prevention of phrenic nerve injury (PNI). Methods Patients

KW - atrial fibrillation

KW - cryoballoon

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KW - safety

KW - PULMONARY VEIN ISOLATION

KW - PAROXYSMAL ATRIAL-FIBRILLATION

KW - 28 MM CRYOBALLOON

KW - 2ND-GENERATION CRYOBALLOON

KW - CLINICAL SUCCESS

KW - 3-MINUTE FREEZE

KW - BONUS-FREEZE

KW - ABLATION

KW - PALSY

KW - CRYOABLATION

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DO - 10.1111/pace.13626

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