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Shaping Cell Fate: Influence of Topographical Substratum Properties on Embryonic Stem Cells

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Development of multicellular organisms is a highly orchestrated process, with cells responding to factors and features present in the extracellular milieu. Changes in the surrounding environment help decide the fate of cells at various stages of development. This review highlights recent research that details the effects of mechanical properties of the surrounding environment and extracellular matrix and the underlying molecular mechanisms that regulate the behavior of embryonic stem cells (ESCs). In this study, we review the role of mechanical properties during embryogenesis and discuss the effect of engineered microtopographies on ESC pluripotency.

    Research areas

  • Journal Article, DEVELOPMENTAL REGULATORS, embryonic stem cells, HIPPO PATHWAY, TRANSCRIPTIONAL REGULATORY CIRCUITRY, SELF-RENEWAL, OSTEOGENIC DIFFERENTIATION, pluripotency, NANOTOPOGRAPHY, ADHESION, substratum, EXTRACELLULAR-MATRIX, extracellular matrix, NEURAL DIFFERENTIATION, MORPHOLOGY, Extracellular Matrix/metabolism, Human Embryonic Stem Cells/cytology, Tissue Engineering/methods, Stem Cell Niche, Humans, Embryonic Development, Animals
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Original languageEnglish
Pages (from-to)255-266
Number of pages12
JournalTissue Engineering - Part B: Reviews
Issue number4
Publication statusPublished - Aug 2018