Shaping Cell Fate: Influence of Topographical Substratum Properties on Embryonic Stem Cells

Sarita Kumari; Steven Vermeulen; Ben van der Veer; Aurélie Carlier; Jan de Boer; Deepa Subramanyam

doi:10.1089/ten.TEB.2017.0468

Shaping Cell Fate: Influence of Topographical Substratum Properties on Embryonic Stem Cells

Sarita Kumari, Steven Vermeulen, Ben van der Veer, Aurélie Carlier, Jan de Boer, Deepa Subramanyam^*

^*Corresponding author for this work

Research output: Contribution to journal › (Systematic) Review article › peer-review

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Abstract

Development of multicellular organisms is a highly orchestrated process, with cells responding to factors and features present in the extracellular milieu. Changes in the surrounding environment help decide the fate of cells at various stages of development. This review highlights recent research that details the effects of mechanical properties of the surrounding environment and extracellular matrix and the underlying molecular mechanisms that regulate the behavior of embryonic stem cells (ESCs). In this study, we review the role of mechanical properties during embryogenesis and discuss the effect of engineered microtopographies on ESC pluripotency.

Original language	English
Pages (from-to)	255-266
Number of pages	12
Journal	Tissue Engineering - Part B: Reviews
Volume	24
Issue number	4
DOIs	https://doi.org/10.1089/ten.TEB.2017.0468
Publication status	Published - Aug 2018

Keywords

Journal Article
DEVELOPMENTAL REGULATORS
embryonic stem cells
HIPPO PATHWAY
TRANSCRIPTIONAL REGULATORY CIRCUITRY
SELF-RENEWAL
OSTEOGENIC DIFFERENTIATION
pluripotency
NANOTOPOGRAPHY
ADHESION
substratum
EXTRACELLULAR-MATRIX
extracellular matrix
NEURAL DIFFERENTIATION
MORPHOLOGY
Extracellular Matrix/metabolism
Human Embryonic Stem Cells/cytology
Tissue Engineering/methods
Stem Cell Niche
Humans
Embryonic Development
Animals

Access to Document

10.1089/ten.TEB.2017.0468

Author's versionAccepted author manuscript, 382 KBLicence: CC BY-NC-ND
Full TextFinal published version, 629 KBLicence: Taverne

Cite this

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title = "Shaping Cell Fate: Influence of Topographical Substratum Properties on Embryonic Stem Cells",

abstract = "Development of multicellular organisms is a highly orchestrated process, with cells responding to factors and features present in the extracellular milieu. Changes in the surrounding environment help decide the fate of cells at various stages of development. This review highlights recent research that details the effects of mechanical properties of the surrounding environment and extracellular matrix and the underlying molecular mechanisms that regulate the behavior of embryonic stem cells (ESCs). In this study, we review the role of mechanical properties during embryogenesis and discuss the effect of engineered microtopographies on ESC pluripotency.",

keywords = "Journal Article, DEVELOPMENTAL REGULATORS, embryonic stem cells, HIPPO PATHWAY, TRANSCRIPTIONAL REGULATORY CIRCUITRY, SELF-RENEWAL, OSTEOGENIC DIFFERENTIATION, pluripotency, NANOTOPOGRAPHY, ADHESION, substratum, EXTRACELLULAR-MATRIX, extracellular matrix, NEURAL DIFFERENTIATION, MORPHOLOGY, Extracellular Matrix/metabolism, Human Embryonic Stem Cells/cytology, Tissue Engineering/methods, Stem Cell Niche, Humans, Embryonic Development, Animals",

author = "Sarita Kumari and Steven Vermeulen and {van der Veer}, Ben and Aur{\'e}lie Carlier and {de Boer}, Jan and Deepa Subramanyam",

year = "2018",

month = aug,

doi = "10.1089/ten.TEB.2017.0468",

language = "English",

volume = "24",

pages = "255--266",

journal = "Tissue Engineering - Part B: Reviews",

issn = "1937-3368",

publisher = "Mary Ann Liebert Inc.",

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T1 - Shaping Cell Fate

T2 - Influence of Topographical Substratum Properties on Embryonic Stem Cells

AU - Kumari, Sarita

AU - Vermeulen, Steven

AU - van der Veer, Ben

AU - Carlier, Aurélie

AU - de Boer, Jan

AU - Subramanyam, Deepa

PY - 2018/8

Y1 - 2018/8

N2 - Development of multicellular organisms is a highly orchestrated process, with cells responding to factors and features present in the extracellular milieu. Changes in the surrounding environment help decide the fate of cells at various stages of development. This review highlights recent research that details the effects of mechanical properties of the surrounding environment and extracellular matrix and the underlying molecular mechanisms that regulate the behavior of embryonic stem cells (ESCs). In this study, we review the role of mechanical properties during embryogenesis and discuss the effect of engineered microtopographies on ESC pluripotency.

AB - Development of multicellular organisms is a highly orchestrated process, with cells responding to factors and features present in the extracellular milieu. Changes in the surrounding environment help decide the fate of cells at various stages of development. This review highlights recent research that details the effects of mechanical properties of the surrounding environment and extracellular matrix and the underlying molecular mechanisms that regulate the behavior of embryonic stem cells (ESCs). In this study, we review the role of mechanical properties during embryogenesis and discuss the effect of engineered microtopographies on ESC pluripotency.

KW - Journal Article

KW - DEVELOPMENTAL REGULATORS

KW - embryonic stem cells

KW - HIPPO PATHWAY

KW - TRANSCRIPTIONAL REGULATORY CIRCUITRY

KW - SELF-RENEWAL

KW - OSTEOGENIC DIFFERENTIATION

KW - pluripotency

KW - NANOTOPOGRAPHY

KW - ADHESION

KW - substratum

KW - EXTRACELLULAR-MATRIX

KW - extracellular matrix

KW - NEURAL DIFFERENTIATION

KW - MORPHOLOGY

KW - Extracellular Matrix/metabolism

KW - Human Embryonic Stem Cells/cytology

KW - Tissue Engineering/methods

KW - Stem Cell Niche

KW - Humans

KW - Embryonic Development

KW - Animals

U2 - 10.1089/ten.TEB.2017.0468

DO - 10.1089/ten.TEB.2017.0468

M3 - (Systematic) Review article

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SN - 1937-3368

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SP - 255

EP - 266

JO - Tissue Engineering - Part B: Reviews

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