Sex hormone-binding globulin and thrombin generation in women using hormonal contraception

Justine Hugon-Rodin*, Martine Alhenc-Gelas, H. Coenraad Hemker, Sylvie Brailly-Tabard, Anne Guiochon-Mantel, Genevieve Plu-Bureau, Pierre-Yves Scarabin

*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Objectives: We investigated the impact of serum sex hormone-binding globulin (SHBG) on thrombin generation (TG) in women according to hormonal contraception.

Patients and methods: A cross-sectional study of SHBG and TG measured via calibrated automated thrombography was conducted in 150 healthy women, including 75 users of combined oral contraceptives (COC), 22 users of progestin-only contraceptives (POC) and 53 nonusers.

Results: COC but not POC-users had significantly higher SHBG levels compared with nonusers. In hormonal contraceptive users, SHBG was positively associated with both activated protein C (APC) resistance and baseline TG, and protein S and prothrombin were important mediators.

Conclusion: These data provide further evidence that SHBG may be used as a biomarker in assessing prothrombotic profile of hormonal contraception.

Original languageEnglish
Pages (from-to)81-85
Number of pages5
JournalBiomarkers
Volume22
Issue number1
DOIs
Publication statusPublished - 2017

Keywords

  • Biomarkers
  • hemostasis
  • prothrombotic
  • PROGESTIN-ONLY CONTRACEPTION
  • COMBINED ORAL-CONTRACEPTIVES
  • PROTEIN-C RESISTANCE
  • VENOUS THROMBOEMBOLISM
  • SURROGATE MARKER
  • RISK
  • PLASMA
  • METAANALYSIS
  • COAGULATION
  • THERAPY

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