Severe seizures as a side effect of deep brain stimulation in the dorsal peduncular cortex in a rat model of depression

Milaine Roet; Sylvana Pol; Frederic L. W. V. J. Schaper; Govert Hoogland; Ali Jahanshahi; Yasin Temel

doi:10.1016/j.yebeh.2019.01.007

Severe seizures as a side effect of deep brain stimulation in the dorsal peduncular cortex in a rat model of depression

Milaine Roet^*, Sylvana Pol, Frederic L. W. V. J. Schaper, Govert Hoogland, Ali Jahanshahi, Yasin Temel^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Deep brain stimulation (DBS) has shown to have antidepressant effects in both human trials and animal studies. However, the optimal target and the underlying therapeutic mechanisms remain to be determined. In this study, we investigated if high frequency (HF) DBS in the dorsal peduncular cortex (DPC) alleviates depressive-like behavior in an experimental model of depression. Surprisingly, HF DBS in the DPC caused acute induction of seizures in similar to 40% of animals stimulated with clinically relevant stimulation parameters. Reducing the stimulation's amplitude by 50% did not alter seizure occurrence. Electroencephalographic (EEG) recordings showed seizures up to Racine stage IV lasting up to 4 min after cessation of stimulation. We conclude that HF DBS in the DPC is not suitable for mood-related experiments in rats but could be a potential model for seizure induction. (C) 2019 Elsevier Inc. All rights reserved.

Original language	English
Pages (from-to)	269-275
Number of pages	7
Journal	Epilepsy & Behavior
Volume	92
DOIs	https://doi.org/10.1016/j.yebeh.2019.01.007
Publication status	Published - Mar 2019

Keywords

High frequency (HF)
Deep brain stimulation (DBS)
Ventromedial prefrontal cortex (vmPFC)
Dorsal peduncular cortex (DPC)
Seizure
ELECTRICAL-STIMULATION
PREFRONTAL CORTEX
PROJECTIONS
EXTINCTION
BEHAVIORS
MOTOR
FEAR

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10.1016/j.yebeh.2019.01.007

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Cite this

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title = "Severe seizures as a side effect of deep brain stimulation in the dorsal peduncular cortex in a rat model of depression",

abstract = "Deep brain stimulation (DBS) has shown to have antidepressant effects in both human trials and animal studies. However, the optimal target and the underlying therapeutic mechanisms remain to be determined. In this study, we investigated if high frequency (HF) DBS in the dorsal peduncular cortex (DPC) alleviates depressive-like behavior in an experimental model of depression. Surprisingly, HF DBS in the DPC caused acute induction of seizures in similar to 40% of animals stimulated with clinically relevant stimulation parameters. Reducing the stimulation's amplitude by 50% did not alter seizure occurrence. Electroencephalographic (EEG) recordings showed seizures up to Racine stage IV lasting up to 4 min after cessation of stimulation. We conclude that HF DBS in the DPC is not suitable for mood-related experiments in rats but could be a potential model for seizure induction. (C) 2019 Elsevier Inc. All rights reserved.",

keywords = "High frequency (HF), Deep brain stimulation (DBS), Ventromedial prefrontal cortex (vmPFC), Dorsal peduncular cortex (DPC), Seizure, ELECTRICAL-STIMULATION, PREFRONTAL CORTEX, PROJECTIONS, EXTINCTION, BEHAVIORS, MOTOR, FEAR",

author = "Milaine Roet and Sylvana Pol and Schaper, {Frederic L. W. V. J.} and Govert Hoogland and Ali Jahanshahi and Yasin Temel",

note = "Funding Information: We would like to thank Prof. J. Prickaerts and Dr. A. Lim for their expertise and advice concerning the Chronic Unpredictable Mild Stress Model and behavioral paradigms described in this manuscript. This work was supported and funded by the school for Mental Health and Neuroscience (MHeNS) of the University of Maastricht (UM). Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",

year = "2019",

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doi = "10.1016/j.yebeh.2019.01.007",

language = "English",

volume = "92",

pages = "269--275",

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T1 - Severe seizures as a side effect of deep brain stimulation in the dorsal peduncular cortex in a rat model of depression

AU - Roet, Milaine

AU - Pol, Sylvana

AU - Schaper, Frederic L. W. V. J.

AU - Hoogland, Govert

AU - Jahanshahi, Ali

AU - Temel, Yasin

N1 - Funding Information: We would like to thank Prof. J. Prickaerts and Dr. A. Lim for their expertise and advice concerning the Chronic Unpredictable Mild Stress Model and behavioral paradigms described in this manuscript. This work was supported and funded by the school for Mental Health and Neuroscience (MHeNS) of the University of Maastricht (UM). Publisher Copyright: © 2019 Elsevier Inc.

PY - 2019/3

Y1 - 2019/3

N2 - Deep brain stimulation (DBS) has shown to have antidepressant effects in both human trials and animal studies. However, the optimal target and the underlying therapeutic mechanisms remain to be determined. In this study, we investigated if high frequency (HF) DBS in the dorsal peduncular cortex (DPC) alleviates depressive-like behavior in an experimental model of depression. Surprisingly, HF DBS in the DPC caused acute induction of seizures in similar to 40% of animals stimulated with clinically relevant stimulation parameters. Reducing the stimulation's amplitude by 50% did not alter seizure occurrence. Electroencephalographic (EEG) recordings showed seizures up to Racine stage IV lasting up to 4 min after cessation of stimulation. We conclude that HF DBS in the DPC is not suitable for mood-related experiments in rats but could be a potential model for seizure induction. (C) 2019 Elsevier Inc. All rights reserved.

AB - Deep brain stimulation (DBS) has shown to have antidepressant effects in both human trials and animal studies. However, the optimal target and the underlying therapeutic mechanisms remain to be determined. In this study, we investigated if high frequency (HF) DBS in the dorsal peduncular cortex (DPC) alleviates depressive-like behavior in an experimental model of depression. Surprisingly, HF DBS in the DPC caused acute induction of seizures in similar to 40% of animals stimulated with clinically relevant stimulation parameters. Reducing the stimulation's amplitude by 50% did not alter seizure occurrence. Electroencephalographic (EEG) recordings showed seizures up to Racine stage IV lasting up to 4 min after cessation of stimulation. We conclude that HF DBS in the DPC is not suitable for mood-related experiments in rats but could be a potential model for seizure induction. (C) 2019 Elsevier Inc. All rights reserved.

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