Serotonergic, noradrenergic and dopaminergic markers are related to cognitive function in adults with 22q11 deletion syndrome

L.J.M. Evers; L.M.G. Curfs; J.A. Bakker; E. Boot; F. da Silva Alves; N. Abeling; J. Bierau; M. Drukker; T.A.M.J. van Amelsvoort

doi:10.1017/S1461145714000376

Serotonergic, noradrenergic and dopaminergic markers are related to cognitive function in adults with 22q11 deletion syndrome

L.J.M. Evers^*, L.M.G. Curfs, J.A. Bakker, E. Boot, F. da Silva Alves, N. Abeling, J. Bierau, M. Drukker, T.A.M.J. van Amelsvoort

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Patients with 22q11 deletion syndrome (22q11DS) have a high prevalence of psychiatric disorders and intellectual disability. At present the neurobiology underlying psychopathology in 22q11DS is still not understood. In the present study, we analyzed urinary serotonergic, dopaminergic and noradrenergic markers in 67 adults with 22q11DS. Levels of serotonin and the catecholamine metabolite homovanillic acid were significantly lower in the 22q11DS subjects compared to healthy controls. Within the 22q11DS group, levels of dopamine, homovanillic acid, norepinephrine, vanillyl mandelic acid and serotonin positively correlated with Full Scale Intelligence Quotient scores. Our results suggest that cognitive deficits in 22q11DS are associated with abnormal function of several neurotransmitters.

Original language	English
Pages (from-to)	1159-1165
Journal	International Journal of Neuropsychopharmacology
Volume	17
Issue number	8
DOIs	https://doi.org/10.1017/S1461145714000376
Publication status	Published - 1 Jan 2014

Access to Document

10.1017/S1461145714000376

Cite this

Evers, L. J. M., Curfs, L. M. G., Bakker, J. A., Boot, E., da Silva Alves, F., Abeling, N., Bierau, J., Drukker, M., & van Amelsvoort, T. A. M. J. (2014). Serotonergic, noradrenergic and dopaminergic markers are related to cognitive function in adults with 22q11 deletion syndrome. International Journal of Neuropsychopharmacology, 17(8), 1159-1165. https://doi.org/10.1017/S1461145714000376

@article{abc3ba3150de46edb3af3a1d1cc4a30f,

title = "Serotonergic, noradrenergic and dopaminergic markers are related to cognitive function in adults with 22q11 deletion syndrome",

abstract = "Patients with 22q11 deletion syndrome (22q11DS) have a high prevalence of psychiatric disorders and intellectual disability. At present the neurobiology underlying psychopathology in 22q11DS is still not understood. In the present study, we analyzed urinary serotonergic, dopaminergic and noradrenergic markers in 67 adults with 22q11DS. Levels of serotonin and the catecholamine metabolite homovanillic acid were significantly lower in the 22q11DS subjects compared to healthy controls. Within the 22q11DS group, levels of dopamine, homovanillic acid, norepinephrine, vanillyl mandelic acid and serotonin positively correlated with Full Scale Intelligence Quotient scores. Our results suggest that cognitive deficits in 22q11DS are associated with abnormal function of several neurotransmitters.",

author = "L.J.M. Evers and L.M.G. Curfs and J.A. Bakker and E. Boot and {da Silva Alves}, F. and N. Abeling and J. Bierau and M. Drukker and {van Amelsvoort}, T.A.M.J.",

year = "2014",

month = jan,

day = "1",

doi = "10.1017/S1461145714000376",

language = "English",

volume = "17",

pages = "1159--1165",

journal = "International Journal of Neuropsychopharmacology",

issn = "1461-1457",

publisher = "Oxford University Press",

number = "8",

}

Evers, LJM, Curfs, LMG, Bakker, JA, Boot, E, da Silva Alves, F, Abeling, N, Bierau, J, Drukker, M & van Amelsvoort, TAMJ 2014, 'Serotonergic, noradrenergic and dopaminergic markers are related to cognitive function in adults with 22q11 deletion syndrome', International Journal of Neuropsychopharmacology, vol. 17, no. 8, pp. 1159-1165. https://doi.org/10.1017/S1461145714000376

TY - JOUR

T1 - Serotonergic, noradrenergic and dopaminergic markers are related to cognitive function in adults with 22q11 deletion syndrome

AU - Evers, L.J.M.

AU - Curfs, L.M.G.

AU - Bakker, J.A.

AU - Boot, E.

AU - da Silva Alves, F.

AU - Abeling, N.

AU - Bierau, J.

AU - Drukker, M.

AU - van Amelsvoort, T.A.M.J.

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Patients with 22q11 deletion syndrome (22q11DS) have a high prevalence of psychiatric disorders and intellectual disability. At present the neurobiology underlying psychopathology in 22q11DS is still not understood. In the present study, we analyzed urinary serotonergic, dopaminergic and noradrenergic markers in 67 adults with 22q11DS. Levels of serotonin and the catecholamine metabolite homovanillic acid were significantly lower in the 22q11DS subjects compared to healthy controls. Within the 22q11DS group, levels of dopamine, homovanillic acid, norepinephrine, vanillyl mandelic acid and serotonin positively correlated with Full Scale Intelligence Quotient scores. Our results suggest that cognitive deficits in 22q11DS are associated with abnormal function of several neurotransmitters.

AB - Patients with 22q11 deletion syndrome (22q11DS) have a high prevalence of psychiatric disorders and intellectual disability. At present the neurobiology underlying psychopathology in 22q11DS is still not understood. In the present study, we analyzed urinary serotonergic, dopaminergic and noradrenergic markers in 67 adults with 22q11DS. Levels of serotonin and the catecholamine metabolite homovanillic acid were significantly lower in the 22q11DS subjects compared to healthy controls. Within the 22q11DS group, levels of dopamine, homovanillic acid, norepinephrine, vanillyl mandelic acid and serotonin positively correlated with Full Scale Intelligence Quotient scores. Our results suggest that cognitive deficits in 22q11DS are associated with abnormal function of several neurotransmitters.

U2 - 10.1017/S1461145714000376

DO - 10.1017/S1461145714000376

M3 - Article

C2 - 24713114

SN - 1461-1457

VL - 17

SP - 1159

EP - 1165

JO - International Journal of Neuropsychopharmacology

JF - International Journal of Neuropsychopharmacology

IS - 8

ER -