Sequence variant on 8q24 confers susceptibility to urinary bladder cancer

L.A. Kiemeney; S. Thorlacius; P. Sulem; F. Geller; K.K. Aben; S.N. Stacey; J. Gudmundsson; M. Jakobsdottir; J.T. Bergthorsson; A. Sigurdsson; T. Blondal; J.A. Witjes; S.H. Vermeulen; C.A. Hulsbergen van Kaa; D.W. Swinkels; M. Ploeg; E.B. Cornel; H. Vergunst; T.E. Thorgeirsson; D. Gudbjartsson; S.A. Gudjonsson; G. Thorleifsson; K.T. Kristinsson; M. Mouy; S. Snorradottir; D. Placidi; M. Campagna; C. Arici; K. Koppova; E. Gurzau; P. Rudnai; E. Kellen; S. Polidoro; S. Guarrera; C. Sacerdote; M. Sanchez; B. Saez; G. Valdivia; C. Ryk; P. de Verdier; A. Lindblom; K. Golka; D.T. Bishop; M.A. Knowles; S. Nikulasson; V. Petursdottir; E. Jonsson; G. Geirsson; B. Kristjansson; J.I. Mayordomo; G. Steineck; S. Porru; F. Buntinx; M.P. Zeegers; T. Fletcher; R. Kumar; G. Matullo; P. Vineis; A.E. Kiltie; J.R. Gulcher; U. Thorsteinsdottir; A. Kong; T. Rafnar; K. Stefansson

doi:10.1038/ng.229

Sequence variant on 8q24 confers susceptibility to urinary bladder cancer

L.A. Kiemeney, S. Thorlacius, P. Sulem, F. Geller, K.K. Aben, S.N. Stacey, J. Gudmundsson, M. Jakobsdottir, J.T. Bergthorsson, A. Sigurdsson, T. Blondal, J.A. Witjes, S.H. Vermeulen, C.A. Hulsbergen van Kaa, D.W. Swinkels, M. Ploeg, E.B. Cornel, H. Vergunst, T.E. Thorgeirsson, D. GudbjartssonS.A. Gudjonsson, G. Thorleifsson, K.T. Kristinsson, M. Mouy, S. Snorradottir, D. Placidi, M. Campagna, C. Arici, K. Koppova, E. Gurzau, P. Rudnai, E. Kellen, S. Polidoro, S. Guarrera, C. Sacerdote, M. Sanchez, B. Saez, G. Valdivia, C. Ryk, P. de Verdier, A. Lindblom, K. Golka, D.T. Bishop, M.A. Knowles, S. Nikulasson, V. Petursdottir, E. Jonsson, G. Geirsson, B. Kristjansson, J.I. Mayordomo, G. Steineck, S. Porru, F. Buntinx, M.P. Zeegers, T. Fletcher, R. Kumar, G. Matullo, P. Vineis, A.E. Kiltie, J.R. Gulcher, U. Thorsteinsdottir, A. Kong, T. Rafnar, K. Stefansson^*

^*Corresponding author for this work

GROW - School for Oncology and Reproduction

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Abstract

We conducted a genome-wide SNP association study on 1,803 urinary bladder cancer (UBC) cases and 34,336 controls from Iceland and The Netherlands and follow up studies in seven additional case-control groups (2,165 cases and 3,800 controls). The strongest association was observed with allele T of rs9642880 on chromosome 8q24, 30 kb upstream of MYC (allele-specific odds ratio (OR) = 1.22; P = 9.34 x 10(-12)). Approximately 20% of individuals of European ancestry are homozygous for rs9642880[T], and their estimated risk of developing UBC is 1.49 times that of noncarriers. No association was observed between UBC and the four 8q24 variants previously associated with prostate, colorectal and breast cancers, nor did rs9642880 associate with any of these three cancers. A weaker signal, but nonetheless of genome-wide significance, was captured by rs710521[A] located near TP63 on chromosome 3q28 (allele-specific OR = 1.19; P = 1. 15 x 10(-7)).

Original language	English
Pages (from-to)	1307-12
Journal	Nature Genetics
Volume	40
Issue number	11
DOIs	https://doi.org/10.1038/ng.229
Publication status	Published - 1 Jan 2008

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10.1038/ng.229

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Kiemeney, L. A., Thorlacius, S., Sulem, P., Geller, F., Aben, K. K., Stacey, S. N., Gudmundsson, J., Jakobsdottir, M., Bergthorsson, J. T., Sigurdsson, A., Blondal, T., Witjes, J. A., Vermeulen, S. H., Hulsbergen van Kaa, C. A., Swinkels, D. W., Ploeg, M., Cornel, E. B., Vergunst, H., Thorgeirsson, T. E., ... Stefansson, K. (2008). Sequence variant on 8q24 confers susceptibility to urinary bladder cancer. Nature Genetics, 40(11), 1307-12. https://doi.org/10.1038/ng.229

@article{adca38c6e9f2486f9cd5390d757e91a8,

title = "Sequence variant on 8q24 confers susceptibility to urinary bladder cancer",

abstract = "We conducted a genome-wide SNP association study on 1,803 urinary bladder cancer (UBC) cases and 34,336 controls from Iceland and The Netherlands and follow up studies in seven additional case-control groups (2,165 cases and 3,800 controls). The strongest association was observed with allele T of rs9642880 on chromosome 8q24, 30 kb upstream of MYC (allele-specific odds ratio (OR) = 1.22; P = 9.34 x 10(-12)). Approximately 20% of individuals of European ancestry are homozygous for rs9642880[T], and their estimated risk of developing UBC is 1.49 times that of noncarriers. No association was observed between UBC and the four 8q24 variants previously associated with prostate, colorectal and breast cancers, nor did rs9642880 associate with any of these three cancers. A weaker signal, but nonetheless of genome-wide significance, was captured by rs710521[A] located near TP63 on chromosome 3q28 (allele-specific OR = 1.19; P = 1. 15 x 10(-7)).",

author = "L.A. Kiemeney and S. Thorlacius and P. Sulem and F. Geller and K.K. Aben and S.N. Stacey and J. Gudmundsson and M. Jakobsdottir and J.T. Bergthorsson and A. Sigurdsson and T. Blondal and J.A. Witjes and S.H. Vermeulen and {Hulsbergen van Kaa}, C.A. and D.W. Swinkels and M. Ploeg and E.B. Cornel and H. Vergunst and T.E. Thorgeirsson and D. Gudbjartsson and S.A. Gudjonsson and G. Thorleifsson and K.T. Kristinsson and M. Mouy and S. Snorradottir and D. Placidi and M. Campagna and C. Arici and K. Koppova and E. Gurzau and P. Rudnai and E. Kellen and S. Polidoro and S. Guarrera and C. Sacerdote and M. Sanchez and B. Saez and G. Valdivia and C. Ryk and {de Verdier}, P. and A. Lindblom and K. Golka and D.T. Bishop and M.A. Knowles and S. Nikulasson and V. Petursdottir and E. Jonsson and G. Geirsson and B. Kristjansson and J.I. Mayordomo and G. Steineck and S. Porru and F. Buntinx and M.P. Zeegers and T. Fletcher and R. Kumar and G. Matullo and P. Vineis and A.E. Kiltie and J.R. Gulcher and U. Thorsteinsdottir and A. Kong and T. Rafnar and K. Stefansson",

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doi = "10.1038/ng.229",

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volume = "40",

pages = "1307--12",

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Kiemeney, LA, Thorlacius, S, Sulem, P, Geller, F, Aben, KK, Stacey, SN, Gudmundsson, J, Jakobsdottir, M, Bergthorsson, JT, Sigurdsson, A, Blondal, T, Witjes, JA, Vermeulen, SH, Hulsbergen van Kaa, CA, Swinkels, DW, Ploeg, M, Cornel, EB, Vergunst, H, Thorgeirsson, TE, Gudbjartsson, D, Gudjonsson, SA, Thorleifsson, G, Kristinsson, KT, Mouy, M, Snorradottir, S, Placidi, D, Campagna, M, Arici, C, Koppova, K, Gurzau, E, Rudnai, P, Kellen, E, Polidoro, S, Guarrera, S, Sacerdote, C, Sanchez, M, Saez, B, Valdivia, G, Ryk, C, de Verdier, P, Lindblom, A, Golka, K, Bishop, DT, Knowles, MA, Nikulasson, S, Petursdottir, V, Jonsson, E, Geirsson, G, Kristjansson, B, Mayordomo, JI, Steineck, G, Porru, S, Buntinx, F, Zeegers, MP, Fletcher, T, Kumar, R, Matullo, G, Vineis, P, Kiltie, AE, Gulcher, JR, Thorsteinsdottir, U, Kong, A, Rafnar, T & Stefansson, K 2008, 'Sequence variant on 8q24 confers susceptibility to urinary bladder cancer', Nature Genetics, vol. 40, no. 11, pp. 1307-12. https://doi.org/10.1038/ng.229

TY - JOUR

T1 - Sequence variant on 8q24 confers susceptibility to urinary bladder cancer

AU - Kiemeney, L.A.

AU - Thorlacius, S.

AU - Sulem, P.

AU - Geller, F.

AU - Aben, K.K.

AU - Stacey, S.N.

AU - Gudmundsson, J.

AU - Jakobsdottir, M.

AU - Bergthorsson, J.T.

AU - Sigurdsson, A.

AU - Blondal, T.

AU - Witjes, J.A.

AU - Vermeulen, S.H.

AU - Hulsbergen van Kaa, C.A.

AU - Swinkels, D.W.

AU - Ploeg, M.

AU - Cornel, E.B.

AU - Vergunst, H.

AU - Thorgeirsson, T.E.

AU - Gudbjartsson, D.

AU - Gudjonsson, S.A.

AU - Thorleifsson, G.

AU - Kristinsson, K.T.

AU - Mouy, M.

AU - Snorradottir, S.

AU - Placidi, D.

AU - Campagna, M.

AU - Arici, C.

AU - Koppova, K.

AU - Gurzau, E.

AU - Rudnai, P.

AU - Kellen, E.

AU - Polidoro, S.

AU - Guarrera, S.

AU - Sacerdote, C.

AU - Sanchez, M.

AU - Saez, B.

AU - Valdivia, G.

AU - Ryk, C.

AU - de Verdier, P.

AU - Lindblom, A.

AU - Golka, K.

AU - Bishop, D.T.

AU - Knowles, M.A.

AU - Nikulasson, S.

AU - Petursdottir, V.

AU - Jonsson, E.

AU - Geirsson, G.

AU - Kristjansson, B.

AU - Mayordomo, J.I.

AU - Steineck, G.

AU - Porru, S.

AU - Buntinx, F.

AU - Zeegers, M.P.

AU - Fletcher, T.

AU - Kumar, R.

AU - Matullo, G.

AU - Vineis, P.

AU - Kiltie, A.E.

AU - Gulcher, J.R.

AU - Thorsteinsdottir, U.

AU - Kong, A.

AU - Rafnar, T.

AU - Stefansson, K.

PY - 2008/1/1

Y1 - 2008/1/1

N2 - We conducted a genome-wide SNP association study on 1,803 urinary bladder cancer (UBC) cases and 34,336 controls from Iceland and The Netherlands and follow up studies in seven additional case-control groups (2,165 cases and 3,800 controls). The strongest association was observed with allele T of rs9642880 on chromosome 8q24, 30 kb upstream of MYC (allele-specific odds ratio (OR) = 1.22; P = 9.34 x 10(-12)). Approximately 20% of individuals of European ancestry are homozygous for rs9642880[T], and their estimated risk of developing UBC is 1.49 times that of noncarriers. No association was observed between UBC and the four 8q24 variants previously associated with prostate, colorectal and breast cancers, nor did rs9642880 associate with any of these three cancers. A weaker signal, but nonetheless of genome-wide significance, was captured by rs710521[A] located near TP63 on chromosome 3q28 (allele-specific OR = 1.19; P = 1. 15 x 10(-7)).

AB - We conducted a genome-wide SNP association study on 1,803 urinary bladder cancer (UBC) cases and 34,336 controls from Iceland and The Netherlands and follow up studies in seven additional case-control groups (2,165 cases and 3,800 controls). The strongest association was observed with allele T of rs9642880 on chromosome 8q24, 30 kb upstream of MYC (allele-specific odds ratio (OR) = 1.22; P = 9.34 x 10(-12)). Approximately 20% of individuals of European ancestry are homozygous for rs9642880[T], and their estimated risk of developing UBC is 1.49 times that of noncarriers. No association was observed between UBC and the four 8q24 variants previously associated with prostate, colorectal and breast cancers, nor did rs9642880 associate with any of these three cancers. A weaker signal, but nonetheless of genome-wide significance, was captured by rs710521[A] located near TP63 on chromosome 3q28 (allele-specific OR = 1.19; P = 1. 15 x 10(-7)).

U2 - 10.1038/ng.229

DO - 10.1038/ng.229

M3 - Article

C2 - 18794855

SN - 1061-4036

VL - 40

SP - 1307

EP - 1312

JO - Nature Genetics

JF - Nature Genetics

IS - 11

ER -