S100B urine concentrations in late preterm infants are gestational age and gender dependent

Andrea Sannia; Francesco Maria Risso; Luc J. I. Zimmermann; Antonio W. D. Gavilanes; Hans J. Vles; Diego Gazzolo

doi:10.1016/j.cca.2012.12.013

S100B urine concentrations in late preterm infants are gestational age and gender dependent

Andrea Sannia, Francesco Maria Risso, Luc J. I. Zimmermann, Antonio W. D. Gavilanes, Hans J. Vles, Diego Gazzolo^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Background: Late preterm deliveries (LP, between 34 and 36 wks), have considerably increased in the last decades. About 20-25% of LP infants who require intensive care and morbidity on public health are of great magnitude. Therefore, we aimed at offering a reference curve in LP period of a well-established neurotrophic and brain damage marker namely S100B protein. Methods: We collected, between December 2009 and March 2012, urine samples, at first void (within 6-hours from birth) for S100B assessment, in 277 healthy LP infants consecutively admitted to our units. Standard clinical and laboratory monitoring parameters were also recorded. S100B was measured by using a commercially available immunoluminometric assay. Results: S100B pattern in LP infants was characterized by a slight decrease in protein's concentration from 34 to 35 wks. From 35 wks onwards S100B started to increase reaching a significant difference (P = 0.008) at 36 wks. When corrected for gender, significantly higher (P

Original language	English
Pages (from-to)	31-34
Journal	Clinica Chimica Acta
Volume	417
DOIs	https://doi.org/10.1016/j.cca.2012.12.013
Publication status	Published - 18 Feb 2013

Keywords

S100B
Biomarkers
Late-preterm
Brain development

Access to Document

10.1016/j.cca.2012.12.013

Cite this

@article{9b6b746f67f34f8ba3e500a713552274,

title = "S100B urine concentrations in late preterm infants are gestational age and gender dependent",

abstract = "Background: Late preterm deliveries (LP, between 34 and 36 wks), have considerably increased in the last decades. About 20-25% of LP infants who require intensive care and morbidity on public health are of great magnitude. Therefore, we aimed at offering a reference curve in LP period of a well-established neurotrophic and brain damage marker namely S100B protein. Methods: We collected, between December 2009 and March 2012, urine samples, at first void (within 6-hours from birth) for S100B assessment, in 277 healthy LP infants consecutively admitted to our units. Standard clinical and laboratory monitoring parameters were also recorded. S100B was measured by using a commercially available immunoluminometric assay. Results: S100B pattern in LP infants was characterized by a slight decrease in protein's concentration from 34 to 35 wks. From 35 wks onwards S100B started to increase reaching a significant difference (P = 0.008) at 36 wks. When corrected for gender, significantly higher (P",

keywords = "S100B, Biomarkers, Late-preterm, Brain development",

author = "Andrea Sannia and Risso, {Francesco Maria} and Zimmermann, {Luc J. I.} and Gavilanes, {Antonio W. D.} and Vles, {Hans J.} and Diego Gazzolo",

year = "2013",

month = feb,

day = "18",

doi = "10.1016/j.cca.2012.12.013",

language = "English",

volume = "417",

pages = "31--34",

journal = "Clinica Chimica Acta",

issn = "0009-8981",

publisher = "Elsevier",

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TY - JOUR

T1 - S100B urine concentrations in late preterm infants are gestational age and gender dependent

AU - Sannia, Andrea

AU - Risso, Francesco Maria

AU - Zimmermann, Luc J. I.

AU - Gavilanes, Antonio W. D.

AU - Vles, Hans J.

AU - Gazzolo, Diego

PY - 2013/2/18

Y1 - 2013/2/18

N2 - Background: Late preterm deliveries (LP, between 34 and 36 wks), have considerably increased in the last decades. About 20-25% of LP infants who require intensive care and morbidity on public health are of great magnitude. Therefore, we aimed at offering a reference curve in LP period of a well-established neurotrophic and brain damage marker namely S100B protein. Methods: We collected, between December 2009 and March 2012, urine samples, at first void (within 6-hours from birth) for S100B assessment, in 277 healthy LP infants consecutively admitted to our units. Standard clinical and laboratory monitoring parameters were also recorded. S100B was measured by using a commercially available immunoluminometric assay. Results: S100B pattern in LP infants was characterized by a slight decrease in protein's concentration from 34 to 35 wks. From 35 wks onwards S100B started to increase reaching a significant difference (P = 0.008) at 36 wks. When corrected for gender, significantly higher (P

AB - Background: Late preterm deliveries (LP, between 34 and 36 wks), have considerably increased in the last decades. About 20-25% of LP infants who require intensive care and morbidity on public health are of great magnitude. Therefore, we aimed at offering a reference curve in LP period of a well-established neurotrophic and brain damage marker namely S100B protein. Methods: We collected, between December 2009 and March 2012, urine samples, at first void (within 6-hours from birth) for S100B assessment, in 277 healthy LP infants consecutively admitted to our units. Standard clinical and laboratory monitoring parameters were also recorded. S100B was measured by using a commercially available immunoluminometric assay. Results: S100B pattern in LP infants was characterized by a slight decrease in protein's concentration from 34 to 35 wks. From 35 wks onwards S100B started to increase reaching a significant difference (P = 0.008) at 36 wks. When corrected for gender, significantly higher (P

KW - S100B

KW - Biomarkers

KW - Late-preterm

KW - Brain development

U2 - 10.1016/j.cca.2012.12.013

DO - 10.1016/j.cca.2012.12.013

M3 - Article

SN - 0009-8981

VL - 417

SP - 31

EP - 34

JO - Clinica Chimica Acta

JF - Clinica Chimica Acta

ER -