TY - JOUR
T1 - Resource utilisation and costs in predementia and dementia: a systematic review protocol
AU - Landeiro, Filipa
AU - Wace, Helena
AU - Ghinai, Isaac
AU - Nye, Elsbeth
AU - Mughal, Seher
AU - Walsh, Katie
AU - Roberts, Nia
AU - Lecomte, Pascal
AU - Wittenberg, Raphael
AU - Wolstenholme, Jane
AU - Handels, Ron
AU - Roncancio-Diaz, Emilse
AU - Potashman, Michele H.
AU - Tockhorn-Heidenreich, Antje
AU - Gray, Alastair M.
AU - ROADMAP Grp
PY - 2018/1/23
Y1 - 2018/1/23
N2 - Introduction Dementia is the fastest growing major cause of disability globally with a mounting social and financial impact for patients and their families but also to health and social care systems. This review aims to systematically synthesise evidence on the utilisation of resources and costs incurred by patients and their caregivers and by health and social care services across the full spectrum of dementia, from its preceding preclinical stage to end of life. The main drivers of resources used and costs will also be identified. Methods and analysis A systematic literature review was conducted in MEDLINE, EMBASE, CDSR, CENTRAL, DARE, EconLit, CEA Registry, TRIP, NHS EED, SCI, RePEc and OpenGrey between January 2000 and beginning of May 2017. Two reviewers will independently assess each study for inclusion and disagreements will be resolved by a third reviewer. Data will be extracted using a predefined data extraction form following best practice. Study quality will be assessed with the Effective Public Health Practice Project quality assessment tool. The reporting of costing methodology will be assessed using the British Medical Journal checklist. A narrative synthesis of all studies will be presented for resources used and costs incurred, by level of disease severity when available. If feasible, the data will be synthesised using appropriate statistical techniques. Ethics and dissemination Included articles will be reviewed for an ethics statement. The findings of the review will be disseminated in a related peer-reviewed journal and presented at conferences. They will also contribute to the work developed in the Real World Outcomes across the Alzheimer's disease spectrum for better care: multi-modal data access platform (ROADMAP).
AB - Introduction Dementia is the fastest growing major cause of disability globally with a mounting social and financial impact for patients and their families but also to health and social care systems. This review aims to systematically synthesise evidence on the utilisation of resources and costs incurred by patients and their caregivers and by health and social care services across the full spectrum of dementia, from its preceding preclinical stage to end of life. The main drivers of resources used and costs will also be identified. Methods and analysis A systematic literature review was conducted in MEDLINE, EMBASE, CDSR, CENTRAL, DARE, EconLit, CEA Registry, TRIP, NHS EED, SCI, RePEc and OpenGrey between January 2000 and beginning of May 2017. Two reviewers will independently assess each study for inclusion and disagreements will be resolved by a third reviewer. Data will be extracted using a predefined data extraction form following best practice. Study quality will be assessed with the Effective Public Health Practice Project quality assessment tool. The reporting of costing methodology will be assessed using the British Medical Journal checklist. A narrative synthesis of all studies will be presented for resources used and costs incurred, by level of disease severity when available. If feasible, the data will be synthesised using appropriate statistical techniques. Ethics and dissemination Included articles will be reviewed for an ethics statement. The findings of the review will be disseminated in a related peer-reviewed journal and presented at conferences. They will also contribute to the work developed in the Real World Outcomes across the Alzheimer's disease spectrum for better care: multi-modal data access platform (ROADMAP).
KW - ALZHEIMERS-DISEASE
KW - OF-ILLNESS
KW - Caregivers/economics
KW - Risk Assessment
KW - Cost-Benefit Analysis
KW - Humans
KW - Systematic Reviews as Topic
KW - Health Resources/statistics & numerical data
KW - Research Design
KW - Dementia/economics
U2 - 10.1136/bmjopen-2017-019060
DO - 10.1136/bmjopen-2017-019060
M3 - (Systematic) Review article
C2 - 29362261
SN - 2044-6055
VL - 8
JO - BMJ Open
JF - BMJ Open
IS - 1
M1 - e019060
ER -