TY - JOUR
T1 - Residual effects on actual car driving of evening doses of chlorpheniramine 8 and 12 mg when used with terfenadine 60mg in the morning.
AU - Vermeeren, A.
AU - Ramaekers, J.G.
AU - van Leeuwen, C.J.
AU - O'Hanlon, J.F.
PY - 1998/1/1
Y1 - 1998/1/1
N2 - The study was conducted according to a 4-way, observer- and subject-blind, cross-over design. Its purpose was to compare the repeated dose effects on actual driving performance of the following: the combination of chlorpheniramine 8 and 12 mg, in sustained release formulations, administered at bedtime and terfenadine 60 mg the following morning; flurazepam 30 mg at bedtime and placebo the following morning; and, placebo at both times. Subjects were 24 healthy female volunteers. Drug effects were assessed in two driving tests (highway driving and car-following) in the morning of the third treatment day. Results show no significant differences in driving performance between both chlorpheniramine/terfenadine treatments and placebo. Flurazepam significantly impaired driving in both tests.
AB - The study was conducted according to a 4-way, observer- and subject-blind, cross-over design. Its purpose was to compare the repeated dose effects on actual driving performance of the following: the combination of chlorpheniramine 8 and 12 mg, in sustained release formulations, administered at bedtime and terfenadine 60 mg the following morning; flurazepam 30 mg at bedtime and placebo the following morning; and, placebo at both times. Subjects were 24 healthy female volunteers. Drug effects were assessed in two driving tests (highway driving and car-following) in the morning of the third treatment day. Results show no significant differences in driving performance between both chlorpheniramine/terfenadine treatments and placebo. Flurazepam significantly impaired driving in both tests.
U2 - 10.1002/(SICI)1099-1077(1998110)13:2+<S79::AID-HUP52>3.3.CO;2-3
DO - 10.1002/(SICI)1099-1077(1998110)13:2+<S79::AID-HUP52>3.3.CO;2-3
M3 - Article
SN - 0885-6222
VL - 13
SP - S79-S86
JO - Human Psychopharmacology-Clinical and Experimental
JF - Human Psychopharmacology-Clinical and Experimental
IS - S2
ER -