Research update for articles published in EJCI in 2012

R P. Dullaart, N.M. Al-Daghri, M. Ashina, A. Bouzas-Mosquera, N.D. Brunetti, C. Buechler, H.S. Chen, J.J. Corrales, M. D'Archivio, A.D. Cas, G.G. Pino, S.A. Gomez-Abril, D. Gyori, H. Haslacher, C. Herder, M.N. Kerstens, M. Koutsilieris, G. Lupattelli, A. Mocsai, P. MsaouelA. Orfao, P. Ormazabal, R. Pacher, T. Perkmann, J. Peteiro, M. Plischcke, N.L. Reynaert, M.A. Ricci, N.R. Robles, M. Rocha, E.P. Rutten, S. Sabico, F. Santamaria, F. Santoro, A. Schmid, M. Schmidt, H.W. Schytz, K.G. Shyu, H. Tada, B. Thorand, G. Valerio, D.L. Vesely, T.E. Wu, M. Yamagishi, Y.T. Yeh

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Phospholipase Cgamma2 (PLCgamma2) is a critical regulator of osteoclast differentiation and basal bone resorption, which was demonstrated by Kertesz et al. in agreement with previous reports(1). The role of the PLCgamma isoenzyme in bone resorption and in adhesion receptor signalling of osteoclasts was further emphasized in a recent review(2) reinforcing the statements made by Kertesz et al.,(1). Moreover, Dr. Faccio's group provided genetic evidence that targeting PLCgamma2 can suppress inflammatory osteolysis(3). This article is protected by copyright. All rights reserved.
Original languageEnglish
Pages (from-to)1010-1023
Number of pages14
JournalEuropean Journal of Clinical Investigation
Volume44
Issue number10
DOIs
Publication statusPublished - Oct 2014

Keywords

  • CORONARY-ARTERY-DISEASE
  • AUTOSOMAL RECESSIVE HYPERCHOLESTEROLEMIA
  • NEAR-INFRARED SPECTROSCOPY
  • LOW-FREQUENCY OSCILLATIONS
  • ISCHEMIC-HEART-DISEASE
  • SMOOTH-MUSCLE-CELLS
  • OXIDATIVE STRESS
  • METABOLIC SYNDROME
  • ADIPOSE-TISSUE
  • SOLUBLE CD163

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