Reproducibility and variability of quantitative magnetic resonance imaging markers in cerebral small vessel disease

Francois De Guio; Eric Jouvent; Geert Jan Biessels; Sandra E. Black; Carol Brayne; Christopher Chen; Charlotte Cordonnier; Frank-Eric De Leeuw; Martin Dichgans; Fergus Doubal; Marco Duering; Carole Dufouil; Emrah Duzel; Franz Fazekas; Vladimir Hachinski; M. Arfan Ikram; Jennifer Linn; Paul M. Matthews; Bernard Mazoyer; Vincent Mok; Bo Norrving; John T. O'Brien; Leonardo Pantoni; Stefan Ropele; Perminder Sachdev; Reinhold Schmidt; Sudha Seshadri; Eric E. Smith; Luciano A. Sposato; Blossom Stephan; Richard H. Swartz; Christophe Tzourio; Mark van Buchem; Aad van der Lugt; Robert van Oostenbrugge; Meike W. Vernooij; Anand Viswanathan; David Werring; Frank Wollenweber; Joanna M. Wardlaw; Hugues Chabriat

doi:10.1177/0271678X16647396

Reproducibility and variability of quantitative magnetic resonance imaging markers in cerebral small vessel disease

Francois De Guio, Eric Jouvent, Geert Jan Biessels, Sandra E. Black, Carol Brayne, Christopher Chen, Charlotte Cordonnier, Frank-Eric De Leeuw, Martin Dichgans, Fergus Doubal, Marco Duering, Carole Dufouil, Emrah Duzel, Franz Fazekas, Vladimir Hachinski, M. Arfan Ikram, Jennifer Linn, Paul M. Matthews, Bernard Mazoyer, Vincent MokBo Norrving, John T. O'Brien, Leonardo Pantoni, Stefan Ropele, Perminder Sachdev, Reinhold Schmidt, Sudha Seshadri, Eric E. Smith, Luciano A. Sposato, Blossom Stephan, Richard H. Swartz, Christophe Tzourio, Mark van Buchem, Aad van der Lugt, Robert van Oostenbrugge, Meike W. Vernooij, Anand Viswanathan, David Werring, Frank Wollenweber, Joanna M. Wardlaw, Hugues Chabriat^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Brain imaging is essential for the diagnosis and characterization of cerebral small vessel disease. Several magnetic resonance imaging markers have therefore emerged, providing new information on the diagnosis, progression, and mechanisms of small vessel disease. Yet, the reproducibility of these small vessel disease markers has received little attention despite being widely used in cross-sectional and longitudinal studies. This review focuses on the main small vessel disease-related markers on magnetic resonance imaging including: white matter hyperintensities, lacunes, dilated perivascular spaces, microbleeds, and brain volume. The aim is to summarize, for each marker, what is currently known about: (1) its reproducibility in studies with a scan-rescan procedure either in single or multicenter settings; (2) the acquisition-related sources of variability; and, (3) the techniques used to minimize this variability. Based on the results, we discuss technical and other challenges that need to be overcome in order for these markers to be reliably used as outcome measures in future clinical trials. We also highlight the key points that need to be considered when designing multicenter magnetic resonance imaging studies of small vessel disease.

Original language	English
Pages (from-to)	1319-1337
Journal	Journal of Cerebral Blood Flow and Metabolism
Volume	36
Issue number	8
DOIs	https://doi.org/10.1177/0271678X16647396
Publication status	Published - Aug 2016

Keywords

Magnetic resonance imaging
cerebral small vessel disease
marker
brain volume
atrophy
white matter hyperintensities
microbleeds
lacunes
perivascular spaces
reproducibility
repeatability
variability

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10.1177/0271678X16647396

Cite this

De Guio, F., Jouvent, E., Biessels, G. J., Black, S. E., Brayne, C., Chen, C., Cordonnier, C., De Leeuw, F.-E., Dichgans, M., Doubal, F., Duering, M., Dufouil, C., Duzel, E., Fazekas, F., Hachinski, V., Ikram, M. A., Linn, J., Matthews, P. M., Mazoyer, B., ... Chabriat, H. (2016). Reproducibility and variability of quantitative magnetic resonance imaging markers in cerebral small vessel disease. Journal of Cerebral Blood Flow and Metabolism, 36(8), 1319-1337. https://doi.org/10.1177/0271678X16647396

@article{d9e1a42275af412e8a0cc6278acd6e69,

title = "Reproducibility and variability of quantitative magnetic resonance imaging markers in cerebral small vessel disease",

abstract = "Brain imaging is essential for the diagnosis and characterization of cerebral small vessel disease. Several magnetic resonance imaging markers have therefore emerged, providing new information on the diagnosis, progression, and mechanisms of small vessel disease. Yet, the reproducibility of these small vessel disease markers has received little attention despite being widely used in cross-sectional and longitudinal studies. This review focuses on the main small vessel disease-related markers on magnetic resonance imaging including: white matter hyperintensities, lacunes, dilated perivascular spaces, microbleeds, and brain volume. The aim is to summarize, for each marker, what is currently known about: (1) its reproducibility in studies with a scan-rescan procedure either in single or multicenter settings; (2) the acquisition-related sources of variability; and, (3) the techniques used to minimize this variability. Based on the results, we discuss technical and other challenges that need to be overcome in order for these markers to be reliably used as outcome measures in future clinical trials. We also highlight the key points that need to be considered when designing multicenter magnetic resonance imaging studies of small vessel disease.",

keywords = "Magnetic resonance imaging, cerebral small vessel disease, marker, brain volume, atrophy, white matter hyperintensities, microbleeds, lacunes, perivascular spaces, reproducibility, repeatability, variability",

author = "{De Guio}, Francois and Eric Jouvent and Biessels, {Geert Jan} and Black, {Sandra E.} and Carol Brayne and Christopher Chen and Charlotte Cordonnier and {De Leeuw}, Frank-Eric and Martin Dichgans and Fergus Doubal and Marco Duering and Carole Dufouil and Emrah Duzel and Franz Fazekas and Vladimir Hachinski and Ikram, {M. Arfan} and Jennifer Linn and Matthews, {Paul M.} and Bernard Mazoyer and Vincent Mok and Bo Norrving and O'Brien, {John T.} and Leonardo Pantoni and Stefan Ropele and Perminder Sachdev and Reinhold Schmidt and Sudha Seshadri and Smith, {Eric E.} and Sposato, {Luciano A.} and Blossom Stephan and Swartz, {Richard H.} and Christophe Tzourio and {van Buchem}, Mark and {van der Lugt}, Aad and {van Oostenbrugge}, Robert and Vernooij, {Meike W.} and Anand Viswanathan and David Werring and Frank Wollenweber and Wardlaw, {Joanna M.} and Hugues Chabriat",

year = "2016",

month = aug,

doi = "10.1177/0271678X16647396",

language = "English",

volume = "36",

pages = "1319--1337",

journal = "Journal of Cerebral Blood Flow and Metabolism",

issn = "0271-678X",

publisher = "SAGE Publications Inc.",

number = "8",

}

De Guio, F, Jouvent, E, Biessels, GJ, Black, SE, Brayne, C, Chen, C, Cordonnier, C, De Leeuw, F-E, Dichgans, M, Doubal, F, Duering, M, Dufouil, C, Duzel, E, Fazekas, F, Hachinski, V, Ikram, MA, Linn, J, Matthews, PM, Mazoyer, B, Mok, V, Norrving, B, O'Brien, JT, Pantoni, L, Ropele, S, Sachdev, P, Schmidt, R, Seshadri, S, Smith, EE, Sposato, LA, Stephan, B, Swartz, RH, Tzourio, C, van Buchem, M, van der Lugt, A, van Oostenbrugge, R, Vernooij, MW, Viswanathan, A, Werring, D, Wollenweber, F, Wardlaw, JM & Chabriat, H 2016, 'Reproducibility and variability of quantitative magnetic resonance imaging markers in cerebral small vessel disease', Journal of Cerebral Blood Flow and Metabolism, vol. 36, no. 8, pp. 1319-1337. https://doi.org/10.1177/0271678X16647396

TY - JOUR

T1 - Reproducibility and variability of quantitative magnetic resonance imaging markers in cerebral small vessel disease

AU - De Guio, Francois

AU - Jouvent, Eric

AU - Biessels, Geert Jan

AU - Black, Sandra E.

AU - Brayne, Carol

AU - Chen, Christopher

AU - Cordonnier, Charlotte

AU - De Leeuw, Frank-Eric

AU - Dichgans, Martin

AU - Doubal, Fergus

AU - Duering, Marco

AU - Dufouil, Carole

AU - Duzel, Emrah

AU - Fazekas, Franz

AU - Hachinski, Vladimir

AU - Ikram, M. Arfan

AU - Linn, Jennifer

AU - Matthews, Paul M.

AU - Mazoyer, Bernard

AU - Mok, Vincent

AU - Norrving, Bo

AU - O'Brien, John T.

AU - Pantoni, Leonardo

AU - Ropele, Stefan

AU - Sachdev, Perminder

AU - Schmidt, Reinhold

AU - Seshadri, Sudha

AU - Smith, Eric E.

AU - Sposato, Luciano A.

AU - Stephan, Blossom

AU - Swartz, Richard H.

AU - Tzourio, Christophe

AU - van Buchem, Mark

AU - van der Lugt, Aad

AU - van Oostenbrugge, Robert

AU - Vernooij, Meike W.

AU - Viswanathan, Anand

AU - Werring, David

AU - Wollenweber, Frank

AU - Wardlaw, Joanna M.

AU - Chabriat, Hugues

PY - 2016/8

Y1 - 2016/8

N2 - Brain imaging is essential for the diagnosis and characterization of cerebral small vessel disease. Several magnetic resonance imaging markers have therefore emerged, providing new information on the diagnosis, progression, and mechanisms of small vessel disease. Yet, the reproducibility of these small vessel disease markers has received little attention despite being widely used in cross-sectional and longitudinal studies. This review focuses on the main small vessel disease-related markers on magnetic resonance imaging including: white matter hyperintensities, lacunes, dilated perivascular spaces, microbleeds, and brain volume. The aim is to summarize, for each marker, what is currently known about: (1) its reproducibility in studies with a scan-rescan procedure either in single or multicenter settings; (2) the acquisition-related sources of variability; and, (3) the techniques used to minimize this variability. Based on the results, we discuss technical and other challenges that need to be overcome in order for these markers to be reliably used as outcome measures in future clinical trials. We also highlight the key points that need to be considered when designing multicenter magnetic resonance imaging studies of small vessel disease.

AB - Brain imaging is essential for the diagnosis and characterization of cerebral small vessel disease. Several magnetic resonance imaging markers have therefore emerged, providing new information on the diagnosis, progression, and mechanisms of small vessel disease. Yet, the reproducibility of these small vessel disease markers has received little attention despite being widely used in cross-sectional and longitudinal studies. This review focuses on the main small vessel disease-related markers on magnetic resonance imaging including: white matter hyperintensities, lacunes, dilated perivascular spaces, microbleeds, and brain volume. The aim is to summarize, for each marker, what is currently known about: (1) its reproducibility in studies with a scan-rescan procedure either in single or multicenter settings; (2) the acquisition-related sources of variability; and, (3) the techniques used to minimize this variability. Based on the results, we discuss technical and other challenges that need to be overcome in order for these markers to be reliably used as outcome measures in future clinical trials. We also highlight the key points that need to be considered when designing multicenter magnetic resonance imaging studies of small vessel disease.

KW - Magnetic resonance imaging

KW - cerebral small vessel disease

KW - marker

KW - brain volume

KW - atrophy

KW - white matter hyperintensities

KW - microbleeds

KW - lacunes

KW - perivascular spaces

KW - reproducibility

KW - repeatability

KW - variability

U2 - 10.1177/0271678X16647396

DO - 10.1177/0271678X16647396

M3 - Article

C2 - 27170700

SN - 0271-678X

VL - 36

SP - 1319

EP - 1337

JO - Journal of Cerebral Blood Flow and Metabolism

JF - Journal of Cerebral Blood Flow and Metabolism

IS - 8

ER -