Recurrent venous thromboembolism and abnormal uterine bleeding with anticoagulant and hormone therapy use

Ida Martinelli; Anthonie W. A. Lensing; Saskia Middeldorp; Marcel Levi; Jan Beyer-Westendorf; Bonno van Bellen; Henri Bounameaux; Timothy A. Brighton; Alexander T. Cohen; Mila Trajanovic; Martin Gebel; Phuong Lam; Philip S. Wells; Martin H. Prins

doi:10.1182/blood-2015-08-665927

Recurrent venous thromboembolism and abnormal uterine bleeding with anticoagulant and hormone therapy use

Ida Martinelli^*, Anthonie W. A. Lensing, Saskia Middeldorp, Marcel Levi, Jan Beyer-Westendorf, Bonno van Bellen, Henri Bounameaux, Timothy A. Brighton, Alexander T. Cohen, Mila Trajanovic, Martin Gebel, Phuong Lam, Philip S. Wells, Martin H. Prins

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Women receiving vitamin K antagonists (VKAs) require adequate contraception because of the potential for fetal complications. It is unknown whether the use of hormonal therapy, especially those containing estrogens, is associated with recurrent venous thromboembolism (VTE) during anticoagulation. Despite the absence of data, World Health Organization guidelines state that use of estrogen-containing contraceptives confers an "unacceptable health risk" during established anticoagulation for VTE. We compared the incidences of recurrent VTE and abnormal uterine bleeding with and without concomitant hormonal therapy in women aged

Original language	English
Pages (from-to)	1417-1425
Journal	Blood
Volume	127
Issue number	11
DOIs	https://doi.org/10.1182/blood-2015-08-665927
Publication status	Published - 17 Mar 2016

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10.1182/blood-2015-08-665927

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Martinelli, I., Lensing, A. W. A., Middeldorp, S., Levi, M., Beyer-Westendorf, J., van Bellen, B., Bounameaux, H., Brighton, T. A., Cohen, A. T., Trajanovic, M., Gebel, M., Phuong Lam, Wells, P. S., & Prins, M. H. (2016). Recurrent venous thromboembolism and abnormal uterine bleeding with anticoagulant and hormone therapy use. Blood, 127(11), 1417-1425. https://doi.org/10.1182/blood-2015-08-665927

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title = "Recurrent venous thromboembolism and abnormal uterine bleeding with anticoagulant and hormone therapy use",

abstract = "Women receiving vitamin K antagonists (VKAs) require adequate contraception because of the potential for fetal complications. It is unknown whether the use of hormonal therapy, especially those containing estrogens, is associated with recurrent venous thromboembolism (VTE) during anticoagulation. Despite the absence of data, World Health Organization guidelines state that use of estrogen-containing contraceptives confers an {"}unacceptable health risk{"} during established anticoagulation for VTE. We compared the incidences of recurrent VTE and abnormal uterine bleeding with and without concomitant hormonal therapy in women aged ",

author = "Ida Martinelli and Lensing, {Anthonie W. A.} and Saskia Middeldorp and Marcel Levi and Jan Beyer-Westendorf and {van Bellen}, Bonno and Henri Bounameaux and Brighton, {Timothy A.} and Cohen, {Alexander T.} and Mila Trajanovic and Martin Gebel and {Phuong Lam} and Wells, {Philip S.} and Prins, {Martin H.}",

year = "2016",

month = mar,

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doi = "10.1182/blood-2015-08-665927",

language = "English",

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journal = "Blood",

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publisher = "The American Society of Hematology",

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Martinelli, I, Lensing, AWA, Middeldorp, S, Levi, M, Beyer-Westendorf, J, van Bellen, B, Bounameaux, H, Brighton, TA, Cohen, AT, Trajanovic, M, Gebel, M, Phuong Lam, Wells, PS & Prins, MH 2016, 'Recurrent venous thromboembolism and abnormal uterine bleeding with anticoagulant and hormone therapy use', Blood, vol. 127, no. 11, pp. 1417-1425. https://doi.org/10.1182/blood-2015-08-665927

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T1 - Recurrent venous thromboembolism and abnormal uterine bleeding with anticoagulant and hormone therapy use

AU - Martinelli, Ida

AU - Lensing, Anthonie W. A.

AU - Middeldorp, Saskia

AU - Levi, Marcel

AU - Beyer-Westendorf, Jan

AU - van Bellen, Bonno

AU - Bounameaux, Henri

AU - Brighton, Timothy A.

AU - Cohen, Alexander T.

AU - Trajanovic, Mila

AU - Gebel, Martin

AU - Phuong Lam,

AU - Wells, Philip S.

AU - Prins, Martin H.

PY - 2016/3/17

Y1 - 2016/3/17

N2 - Women receiving vitamin K antagonists (VKAs) require adequate contraception because of the potential for fetal complications. It is unknown whether the use of hormonal therapy, especially those containing estrogens, is associated with recurrent venous thromboembolism (VTE) during anticoagulation. Despite the absence of data, World Health Organization guidelines state that use of estrogen-containing contraceptives confers an "unacceptable health risk" during established anticoagulation for VTE. We compared the incidences of recurrent VTE and abnormal uterine bleeding with and without concomitant hormonal therapy in women aged

AB - Women receiving vitamin K antagonists (VKAs) require adequate contraception because of the potential for fetal complications. It is unknown whether the use of hormonal therapy, especially those containing estrogens, is associated with recurrent venous thromboembolism (VTE) during anticoagulation. Despite the absence of data, World Health Organization guidelines state that use of estrogen-containing contraceptives confers an "unacceptable health risk" during established anticoagulation for VTE. We compared the incidences of recurrent VTE and abnormal uterine bleeding with and without concomitant hormonal therapy in women aged

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DO - 10.1182/blood-2015-08-665927

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