TY - JOUR
T1 - Recovery from daily-life stressors in early and chronic psychosis
AU - Vaessen, Thomas
AU - Viechtbauer, Wolfgang
AU - van der Steen, Yori
AU - Gayer-Anderson, Charlotte
AU - Kempton, Matthew J.
AU - Valmaggia, Lucia
AU - McGuire, Philip
AU - Murray, Robin
AU - Garety, Philippa
AU - Wykes, Til
AU - Morgan, Craig
AU - Lataster, Tineke
AU - Lataster, Johan
AU - Collip, Dina
AU - Hernaus, Dennis
AU - Kasanova, Zuzana
AU - Delespaul, Philippe
AU - Oorschot, Margreet
AU - Claes, Stephan
AU - Reininghaus, Ulrich
AU - Myin-Germeys, Inez
N1 - Funding Information:
We want to thank Vera Heininga for thinking along about the analysis strategies. All authors declare that they have no conflicts of interest. YvdS, TL and IMG were responsible for the study design, data collection, and data management of the iThink study. CGA, MK, LV, PM, RM, PG, TW, CM, and UR were responsible for the study design, data collection, and data management of the EUGEI study. TL, MO and IMG were responsible for the study design, data collection, and data management of the NARSAD study. JL, DC, and IMG were responsible for the study design, data collection, and data management of the STRIP1 study. DH, ZK and IMG were responsible for the study design, data collection, and data management of the STRIP2 study. PD and IMG were responsible for the study design, data collection, and data management of the MAPS study. TV and WV performed the data analyses. TV carried out the literature searches and wrote the first draft of the manuscript. WV, JL, DH, ZK, SC, UR, and IMG provided critical revisions. All authors contributed to and have approved the final manuscript. This work was supported by an ERC consolidator grant (ERC-2012-StG, project 309767 ? INTERACT) to IMG and a Postdoctoral Research Fellowship of the UK National Institute for Health Research (NIHR-PDF-201104065) and a Heisenberg professorship from the German Research Foundation (389624707) to UR. TV is funded by a Research Foundation Flanders (FWO) Odysseus grant (G0F8416N) to Inez Myin-Germeys and a Horizon 2020 grant (RIA ? 754740).
Funding Information:
We want to thank Vera Heininga for thinking along about the analysis strategies. All authors declare that they have no conflicts of interest. YvdS, TL and IMG were responsible for the study design, data collection, and data management of the iThink study. CGA, MK, LV, PM, RM, PG, TW, CM, and UR were responsible for the study design, data collection, and data management of the EUGEI study. TL, MO and IMG were responsible for the study design, data collection, and data management of the NARSAD study. JL, DC, and IMG were responsible for the study design, data collection, and data management of the STRIP1 study. DH, ZK and IMG were responsible for the study design, data collection, and data management of the STRIP2 study. PD and IMG were responsible for the study design, data collection, and data management of the MAPS study. TV and WV performed the data analyses. TV carried out the literature searches and wrote the first draft of the manuscript. WV, JL, DH, ZK, SC, UR, and IMG provided critical revisions. All authors contributed to and have approved the final manuscript. This work was supported by an ERC consolidator grant (ERC-2012-StG, project 309767 – INTERACT) to IMG and a Postdoctoral Research Fellowship of the UK National Institute for Health Research (NIHR-PDF-201104065) and a Heisenberg professorship from the German Research Foundation (389624707) to UR. TV is funded by a Research Foundation Flanders (FWO) Odysseus grant (G0F8416N) to Inez Myin-Germeys and a Horizon 2020 grant (RIA – 754740).
Publisher Copyright:
© 2019 Elsevier B.V.
PY - 2019/11
Y1 - 2019/11
N2 - Initial affective and psychotic reactivity to daily stressors is altered in psychosis, and most notably in early psychosis. In addition to altered initial stress reactivity, results from studies using Experience Sampling Methodology (ESM) and psychophysiological measures indicate that impaired recovery from mild stressors may also be a risk factor for mental illness.The current ESM study investigated affective recovery from daily stressors in chronic psychosis patients (CP; n = 162), individuals at early stages of psychosis (EP; n = 127), and healthy volunteers (HV; n = 220) assessing fluctuations in negative affect (NA), tension, and suspiciousness ten times a day on six consecutive days. Recovery was operationalized for all three variables as the return to baseline (i.e., level at t(-1)) following the first stressful event of a day (i.e., t(0)).The EP group showed a delayed recovery of NA (t(1)-t(3): B = 0.185; p = .007 and B = 0.228; p = .002) and suspiciousness (t(1): B = 0.223; p = .010 and B = 0291; p = .002) compared to HV and CP, respectively. Delayed recovery was detected for tension as well (t(1)-t(2): EP > HV: B = 0242; p = .040 and EP > CP: B = 0.284; p = .023), but contrary to both other momentary states, this effect disappeared when controlling for subsequent stressful events. There were no significant differences in recovery between HV and CP. These results suggest that in EP, stressful daily events have longer-lasting effects on overall negative affect and subclinical psychotic-like experiences. Future studies should incorporate physiological and endocrine measures in order to integrate recovery patterns of the different stress systems. (C) 2019 Elsevier B.V. All rights reserved.
AB - Initial affective and psychotic reactivity to daily stressors is altered in psychosis, and most notably in early psychosis. In addition to altered initial stress reactivity, results from studies using Experience Sampling Methodology (ESM) and psychophysiological measures indicate that impaired recovery from mild stressors may also be a risk factor for mental illness.The current ESM study investigated affective recovery from daily stressors in chronic psychosis patients (CP; n = 162), individuals at early stages of psychosis (EP; n = 127), and healthy volunteers (HV; n = 220) assessing fluctuations in negative affect (NA), tension, and suspiciousness ten times a day on six consecutive days. Recovery was operationalized for all three variables as the return to baseline (i.e., level at t(-1)) following the first stressful event of a day (i.e., t(0)).The EP group showed a delayed recovery of NA (t(1)-t(3): B = 0.185; p = .007 and B = 0.228; p = .002) and suspiciousness (t(1): B = 0.223; p = .010 and B = 0291; p = .002) compared to HV and CP, respectively. Delayed recovery was detected for tension as well (t(1)-t(2): EP > HV: B = 0242; p = .040 and EP > CP: B = 0.284; p = .023), but contrary to both other momentary states, this effect disappeared when controlling for subsequent stressful events. There were no significant differences in recovery between HV and CP. These results suggest that in EP, stressful daily events have longer-lasting effects on overall negative affect and subclinical psychotic-like experiences. Future studies should incorporate physiological and endocrine measures in order to integrate recovery patterns of the different stress systems. (C) 2019 Elsevier B.V. All rights reserved.
KW - Recovery
KW - Stress
KW - At-risk mental state
KW - First-episode psychosis
KW - Schizophrenia
KW - Ecological momentary assessment
KW - HEART-RATE-VARIABILITY
KW - MENTAL ARITHMETIC STRESS
KW - PITUITARY-ADRENAL AXIS
KW - COMPREHENSIVE ASSESSMENT
KW - HIGH-RISK
KW - SCHIZOPHRENIA
KW - REACTIVITY
KW - SYMPTOMS
KW - INDIVIDUALS
KW - EXPERIENCE
U2 - 10.1016/j.schres.2019.03.011
DO - 10.1016/j.schres.2019.03.011
M3 - Article
C2 - 30930036
SN - 0920-9964
VL - 213
SP - 32
EP - 39
JO - Schizophrenia Research
JF - Schizophrenia Research
ER -