Reasons for (non) participation in supplemental population-based MRI breast screening for women with extremely dense breasts

S. de Lange; M. F. Bakker; E. M. Monninkhof; P. H. M. Peeters; P. K. de Koekkoek-Doll; R. M. Mann; M. J. C. M. Rutten; R. H. C. Bisschops; J. Veltman; K. M. Duvivier; M. B. Lobbes; H. J. de Konin; N. Karssemeijer; R. M. Pijnappel; W. B. Veldhuis; C. H. van Gils

doi:10.1016/j.crad.2018.04.002

Reasons for (non) participation in supplemental population-based MRI breast screening for women with extremely dense breasts

S. de Lange, M. F. Bakker, E. M. Monninkhof, P. H. M. Peeters, P. K. de Koekkoek-Doll, R. M. Mann, M. J. C. M. Rutten, R. H. C. Bisschops, J. Veltman, K. M. Duvivier, M. B. Lobbes, H. J. de Konin, N. Karssemeijer, R. M. Pijnappel, W. B. Veldhuis, C. H. van Gils^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

AIM: To determine the willingness of women with extremely dense breasts to undergo breast cancer screening with magnetic resonance imaging (MRI) in a research setting, and to examine reasons for women to participate or not. MATERIALS AND METHODS: Between 2011 and 2015, 8,061 women (50-75 years) were invited for supplemental MRI as part of the Dense Tissue and Early Breast Neoplasm Screening (DENSE) trial (ClinicalTrials.gov Identifier: NCT01315015), after a negative screening mammography in the national population-based mammography screening programme. Demographics of participants and non-participants were compared. All invitees were asked to report reasons for (non) participation. Ethical approval was obtained. Participants provided written informed consent. RESULTS: Of the 8,061 invitees, 66% answered that they were interested, and 59% eventually participated. Participants were on average 54-years old (interquartile range: 51-59 years), comparable to women with extremely dense breasts in the population-based screening programme (55 years). Women with higher socio-economic status (SES) were more often interested in participation than women with lower SES (68% versus 59%, p<0.001). The most frequently stated reasons for non-participation were "MRI-related inconveniences and/or self-reported contraindications to MRI" (27%) and "anxiety regarding the result of supplemental screening" (21%). "Expected personal health benefit" (68%) and "contribution to science" (43%) were the most frequent reasons for participation. CONCLUSION: Of women invited for MRI because of extremely dense breasts, 59% participated. Common reasons for non-participation were "MRI-related inconveniences" and "anxiety regarding the result of supplemental screening". In case of future implementation, availability of precise evidence on benefits and harms might reduce this anxiety. (C) 2018 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	759.e1-759.e9
Number of pages	9
Journal	Clinical Radiology
Volume	73
Issue number	8
DOIs	https://doi.org/10.1016/j.crad.2018.04.002
Publication status	Published - 1 Aug 2018

Keywords

CANCER RISK
MAMMOGRAPHY
1ST
HIGH-RISK
CANCER

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10.1016/j.crad.2018.04.002

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de Lange, S., Bakker, M. F., Monninkhof, E. M., Peeters, P. H. M., de Koekkoek-Doll, P. K., Mann, R. M., Rutten, M. J. C. M., Bisschops, R. H. C., Veltman, J., Duvivier, K. M., Lobbes, M. B., de Konin, H. J., Karssemeijer, N., Pijnappel, R. M., Veldhuis, W. B., & van Gils, C. H. (2018). Reasons for (non) participation in supplemental population-based MRI breast screening for women with extremely dense breasts. Clinical Radiology, 73(8), 759.e1-759.e9. https://doi.org/10.1016/j.crad.2018.04.002

@article{714446434c564142a7ff7be73411182d,

title = "Reasons for (non) participation in supplemental population-based MRI breast screening for women with extremely dense breasts",

abstract = "AIM: To determine the willingness of women with extremely dense breasts to undergo breast cancer screening with magnetic resonance imaging (MRI) in a research setting, and to examine reasons for women to participate or not. MATERIALS AND METHODS: Between 2011 and 2015, 8,061 women (50-75 years) were invited for supplemental MRI as part of the Dense Tissue and Early Breast Neoplasm Screening (DENSE) trial (ClinicalTrials.gov Identifier: NCT01315015), after a negative screening mammography in the national population-based mammography screening programme. Demographics of participants and non-participants were compared. All invitees were asked to report reasons for (non) participation. Ethical approval was obtained. Participants provided written informed consent. RESULTS: Of the 8,061 invitees, 66% answered that they were interested, and 59% eventually participated. Participants were on average 54-years old (interquartile range: 51-59 years), comparable to women with extremely dense breasts in the population-based screening programme (55 years). Women with higher socio-economic status (SES) were more often interested in participation than women with lower SES (68% versus 59%, p<0.001). The most frequently stated reasons for non-participation were {"}MRI-related inconveniences and/or self-reported contraindications to MRI{"} (27%) and {"}anxiety regarding the result of supplemental screening{"} (21%). {"}Expected personal health benefit{"} (68%) and {"}contribution to science{"} (43%) were the most frequent reasons for participation. CONCLUSION: Of women invited for MRI because of extremely dense breasts, 59% participated. Common reasons for non-participation were {"}MRI-related inconveniences{"} and {"}anxiety regarding the result of supplemental screening{"}. In case of future implementation, availability of precise evidence on benefits and harms might reduce this anxiety. (C) 2018 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.",

keywords = "CANCER RISK, MAMMOGRAPHY, 1ST, HIGH-RISK, CANCER",

author = "{de Lange}, S. and Bakker, {M. F.} and Monninkhof, {E. M.} and Peeters, {P. H. M.} and {de Koekkoek-Doll}, {P. K.} and Mann, {R. M.} and Rutten, {M. J. C. M.} and Bisschops, {R. H. C.} and J. Veltman and Duvivier, {K. M.} and Lobbes, {M. B.} and {de Konin}, {H. J.} and N. Karssemeijer and Pijnappel, {R. M.} and Veldhuis, {W. B.} and {van Gils}, {C. H.}",

year = "2018",

month = aug,

day = "1",

doi = "10.1016/j.crad.2018.04.002",

language = "English",

volume = "73",

pages = "759.e1--759.e9",

journal = "Clinical Radiology",

issn = "0009-9260",

publisher = "Elsevier Saunders",

number = "8",

}

de Lange, S, Bakker, MF, Monninkhof, EM, Peeters, PHM, de Koekkoek-Doll, PK, Mann, RM, Rutten, MJCM, Bisschops, RHC, Veltman, J, Duvivier, KM, Lobbes, MB, de Konin, HJ, Karssemeijer, N, Pijnappel, RM, Veldhuis, WB & van Gils, CH 2018, 'Reasons for (non) participation in supplemental population-based MRI breast screening for women with extremely dense breasts', Clinical Radiology, vol. 73, no. 8, pp. 759.e1-759.e9. https://doi.org/10.1016/j.crad.2018.04.002

TY - JOUR

T1 - Reasons for (non) participation in supplemental population-based MRI breast screening for women with extremely dense breasts

AU - de Lange, S.

AU - Bakker, M. F.

AU - Monninkhof, E. M.

AU - Peeters, P. H. M.

AU - de Koekkoek-Doll, P. K.

AU - Mann, R. M.

AU - Rutten, M. J. C. M.

AU - Bisschops, R. H. C.

AU - Veltman, J.

AU - Duvivier, K. M.

AU - Lobbes, M. B.

AU - de Konin, H. J.

AU - Karssemeijer, N.

AU - Pijnappel, R. M.

AU - Veldhuis, W. B.

AU - van Gils, C. H.

PY - 2018/8/1

Y1 - 2018/8/1

N2 - AIM: To determine the willingness of women with extremely dense breasts to undergo breast cancer screening with magnetic resonance imaging (MRI) in a research setting, and to examine reasons for women to participate or not. MATERIALS AND METHODS: Between 2011 and 2015, 8,061 women (50-75 years) were invited for supplemental MRI as part of the Dense Tissue and Early Breast Neoplasm Screening (DENSE) trial (ClinicalTrials.gov Identifier: NCT01315015), after a negative screening mammography in the national population-based mammography screening programme. Demographics of participants and non-participants were compared. All invitees were asked to report reasons for (non) participation. Ethical approval was obtained. Participants provided written informed consent. RESULTS: Of the 8,061 invitees, 66% answered that they were interested, and 59% eventually participated. Participants were on average 54-years old (interquartile range: 51-59 years), comparable to women with extremely dense breasts in the population-based screening programme (55 years). Women with higher socio-economic status (SES) were more often interested in participation than women with lower SES (68% versus 59%, p<0.001). The most frequently stated reasons for non-participation were "MRI-related inconveniences and/or self-reported contraindications to MRI" (27%) and "anxiety regarding the result of supplemental screening" (21%). "Expected personal health benefit" (68%) and "contribution to science" (43%) were the most frequent reasons for participation. CONCLUSION: Of women invited for MRI because of extremely dense breasts, 59% participated. Common reasons for non-participation were "MRI-related inconveniences" and "anxiety regarding the result of supplemental screening". In case of future implementation, availability of precise evidence on benefits and harms might reduce this anxiety. (C) 2018 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.

AB - AIM: To determine the willingness of women with extremely dense breasts to undergo breast cancer screening with magnetic resonance imaging (MRI) in a research setting, and to examine reasons for women to participate or not. MATERIALS AND METHODS: Between 2011 and 2015, 8,061 women (50-75 years) were invited for supplemental MRI as part of the Dense Tissue and Early Breast Neoplasm Screening (DENSE) trial (ClinicalTrials.gov Identifier: NCT01315015), after a negative screening mammography in the national population-based mammography screening programme. Demographics of participants and non-participants were compared. All invitees were asked to report reasons for (non) participation. Ethical approval was obtained. Participants provided written informed consent. RESULTS: Of the 8,061 invitees, 66% answered that they were interested, and 59% eventually participated. Participants were on average 54-years old (interquartile range: 51-59 years), comparable to women with extremely dense breasts in the population-based screening programme (55 years). Women with higher socio-economic status (SES) were more often interested in participation than women with lower SES (68% versus 59%, p<0.001). The most frequently stated reasons for non-participation were "MRI-related inconveniences and/or self-reported contraindications to MRI" (27%) and "anxiety regarding the result of supplemental screening" (21%). "Expected personal health benefit" (68%) and "contribution to science" (43%) were the most frequent reasons for participation. CONCLUSION: Of women invited for MRI because of extremely dense breasts, 59% participated. Common reasons for non-participation were "MRI-related inconveniences" and "anxiety regarding the result of supplemental screening". In case of future implementation, availability of precise evidence on benefits and harms might reduce this anxiety. (C) 2018 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.

KW - CANCER RISK

KW - MAMMOGRAPHY

KW - 1ST

KW - HIGH-RISK

KW - CANCER

U2 - 10.1016/j.crad.2018.04.002

DO - 10.1016/j.crad.2018.04.002

M3 - Article

C2 - 29759590

SN - 0009-9260

VL - 73

SP - 759.e1-759.e9

JO - Clinical Radiology

JF - Clinical Radiology

IS - 8

ER -