Protective Aptitude of Annexin A1 in Arterial Neointima Formation in Atherosclerosis-Prone Mice-Brief Report

Renske J. de Jong; Nicole Paulin; Patricia Lemnitzer; Joana R. Viola; Carla Winter; Bartolo Ferraro; Jochen Grommes; Christian Weber; Chris Reutelingsperger; Maik Drechsler; Oliver Soehnlein

doi:10.1161/ATVBAHA.116.308744

Protective Aptitude of Annexin A1 in Arterial Neointima Formation in Atherosclerosis-Prone Mice-Brief Report

Renske J. de Jong, Nicole Paulin, Patricia Lemnitzer, Joana R. Viola, Carla Winter, Bartolo Ferraro, Jochen Grommes, Christian Weber, Chris Reutelingsperger, Maik Drechsler, Oliver Soehnlein^*

^*Corresponding author for this work

Biochemie

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Objective-Restenosis as a consequence of arterial injury is aggravated by inflammatory pathways. Here, we investigate the role of the proresolving protein annexin A1 (AnxA1) in healing after wire injury.

Approach and Results-Apoe(-/-) and Apoe(-/-) Anxa1(-/-) mice were subjected to wire injury while fed a high-cholesterol diet. Subsequently, localization of AnxA1 and AnxA1 plasma levels were examined. AnxA1 was found to localize within endothelial cells and macrophages in the neointima. Levels of AnxA1 in the plasma and its lesional expression negatively correlated with neointima size, and in the absence of AnxA1, neointima formation was aggravated by the accumulation and proliferation of macrophages. In contrast, reendothelialization and smooth muscle cell infiltration were not affected in Apoe(-/-) Anxa1(-/-) mice.

Conclusions-AnxA1 is protective in healing after wire injury and could, therefore, be an attractive therapeutic compound to prevent from restenosis after vascular damage.

Original language	English
Pages (from-to)	312-315
Number of pages	4
Journal	Arteriosclerosis Thrombosis and Vascular Biology
Volume	37
Issue number	2
DOIs	https://doi.org/10.1161/ATVBAHA.116.308744
Publication status	Published - Feb 2017

Keywords

annexin A1
macrophage
neointima formation
resolution of inflammation
INFLAMMATION
RECRUITMENT

Access to Document

10.1161/ATVBAHA.116.308744

Cite this

de Jong, R. J., Paulin, N., Lemnitzer, P., Viola, J. R., Winter, C., Ferraro, B., Grommes, J., Weber, C., Reutelingsperger, C., Drechsler, M., & Soehnlein, O. (2017). Protective Aptitude of Annexin A1 in Arterial Neointima Formation in Atherosclerosis-Prone Mice-Brief Report. Arteriosclerosis Thrombosis and Vascular Biology, 37(2), 312-315. https://doi.org/10.1161/ATVBAHA.116.308744

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title = "Protective Aptitude of Annexin A1 in Arterial Neointima Formation in Atherosclerosis-Prone Mice-Brief Report",

abstract = "Objective-Restenosis as a consequence of arterial injury is aggravated by inflammatory pathways. Here, we investigate the role of the proresolving protein annexin A1 (AnxA1) in healing after wire injury.Approach and Results-Apoe(-/-) and Apoe(-/-) Anxa1(-/-) mice were subjected to wire injury while fed a high-cholesterol diet. Subsequently, localization of AnxA1 and AnxA1 plasma levels were examined. AnxA1 was found to localize within endothelial cells and macrophages in the neointima. Levels of AnxA1 in the plasma and its lesional expression negatively correlated with neointima size, and in the absence of AnxA1, neointima formation was aggravated by the accumulation and proliferation of macrophages. In contrast, reendothelialization and smooth muscle cell infiltration were not affected in Apoe(-/-) Anxa1(-/-) mice.Conclusions-AnxA1 is protective in healing after wire injury and could, therefore, be an attractive therapeutic compound to prevent from restenosis after vascular damage.",

keywords = "annexin A1, macrophage, neointima formation, resolution of inflammation, INFLAMMATION, RECRUITMENT",

author = "{de Jong}, {Renske J.} and Nicole Paulin and Patricia Lemnitzer and Viola, {Joana R.} and Carla Winter and Bartolo Ferraro and Jochen Grommes and Christian Weber and Chris Reutelingsperger and Maik Drechsler and Oliver Soehnlein",

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doi = "10.1161/ATVBAHA.116.308744",

language = "English",

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pages = "312--315",

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de Jong, RJ, Paulin, N, Lemnitzer, P, Viola, JR, Winter, C, Ferraro, B, Grommes, J, Weber, C, Reutelingsperger, C, Drechsler, M & Soehnlein, O 2017, 'Protective Aptitude of Annexin A1 in Arterial Neointima Formation in Atherosclerosis-Prone Mice-Brief Report', Arteriosclerosis Thrombosis and Vascular Biology, vol. 37, no. 2, pp. 312-315. https://doi.org/10.1161/ATVBAHA.116.308744

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T1 - Protective Aptitude of Annexin A1 in Arterial Neointima Formation in Atherosclerosis-Prone Mice-Brief Report

AU - de Jong, Renske J.

AU - Paulin, Nicole

AU - Lemnitzer, Patricia

AU - Viola, Joana R.

AU - Winter, Carla

AU - Ferraro, Bartolo

AU - Grommes, Jochen

AU - Weber, Christian

AU - Reutelingsperger, Chris

AU - Drechsler, Maik

AU - Soehnlein, Oliver

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Y1 - 2017/2

N2 - Objective-Restenosis as a consequence of arterial injury is aggravated by inflammatory pathways. Here, we investigate the role of the proresolving protein annexin A1 (AnxA1) in healing after wire injury.Approach and Results-Apoe(-/-) and Apoe(-/-) Anxa1(-/-) mice were subjected to wire injury while fed a high-cholesterol diet. Subsequently, localization of AnxA1 and AnxA1 plasma levels were examined. AnxA1 was found to localize within endothelial cells and macrophages in the neointima. Levels of AnxA1 in the plasma and its lesional expression negatively correlated with neointima size, and in the absence of AnxA1, neointima formation was aggravated by the accumulation and proliferation of macrophages. In contrast, reendothelialization and smooth muscle cell infiltration were not affected in Apoe(-/-) Anxa1(-/-) mice.Conclusions-AnxA1 is protective in healing after wire injury and could, therefore, be an attractive therapeutic compound to prevent from restenosis after vascular damage.

AB - Objective-Restenosis as a consequence of arterial injury is aggravated by inflammatory pathways. Here, we investigate the role of the proresolving protein annexin A1 (AnxA1) in healing after wire injury.Approach and Results-Apoe(-/-) and Apoe(-/-) Anxa1(-/-) mice were subjected to wire injury while fed a high-cholesterol diet. Subsequently, localization of AnxA1 and AnxA1 plasma levels were examined. AnxA1 was found to localize within endothelial cells and macrophages in the neointima. Levels of AnxA1 in the plasma and its lesional expression negatively correlated with neointima size, and in the absence of AnxA1, neointima formation was aggravated by the accumulation and proliferation of macrophages. In contrast, reendothelialization and smooth muscle cell infiltration were not affected in Apoe(-/-) Anxa1(-/-) mice.Conclusions-AnxA1 is protective in healing after wire injury and could, therefore, be an attractive therapeutic compound to prevent from restenosis after vascular damage.

KW - annexin A1

KW - macrophage

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KW - resolution of inflammation

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KW - RECRUITMENT

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