TY - JOUR
T1 - Prevalence of HPV infection in racial-ethnic subgroups of head and neck cancer patients
AU - Ragin, Camille
AU - Liu, Jeffrey C.
AU - Jones, Gieira
AU - Shoyele, Olubunmi
AU - Sowunmi, Bukola
AU - Kennett, Rachel
AU - Gibbs, Denise
AU - Blackman, Elizabeth
AU - Esan, Michael
AU - Brandwein, Margaret S.
AU - Devarajan, Karthik
AU - Bussu, Francesco
AU - Chernock, Rebecca
AU - Chien, Chih-Yen
AU - Cohen, Marc A.
AU - El-Mofty, Samir
AU - Suzuki, Mikio
AU - D'Souza, Gypsyamber
AU - Funchain, Pauline
AU - Eng, Charis
AU - Gollin, Susanne M.
AU - Hong, Angela
AU - Jung, Yuh-S
AU - Krueger, Maximilian
AU - Lewis, James
AU - Morbini, Patrizia
AU - Landolfo, Santo
AU - Ritta, Massimo
AU - Straetmans, Jos
AU - Szarka, Krisztina
AU - Tachezy, Ruth
AU - Worden, Francis P.
AU - Nelson, Deborah
AU - Gathere, Samuel
AU - Taioli, Emanuela
PY - 2017/2
Y1 - 2017/2
N2 - The landscape of human papillomavirus (HPV) infection in racial/ethnic subgroups of head and neck cancer (HNC) patients has not been evaluated carefully. In this study, a meta-analysis examined the prevalence of HPV in HNC patients of African ancestry. Additionally, a pooled analysis of subject- level data was also performed to investigate HPV prevalence and patterns of p16 (CDNK2A) expression amongst different racial groups. Eighteen publications (N = 798 Black HNC patients) were examined in the meta-analysis, and the pooled analysis included 29 datasets comprised of 3129 HNC patients of diverse racial/ethnic background. The meta-analysis revealed that the prevalence of HPV16 was higher among Blacks with oropharyngeal cancer than Blacks with non-oropharyngeal cancer. However, there was great heterogeneity observed among studies (Q test P <0.0001). In the pooled analysis, after adjusting for each study, year of diagnosis, age, gender and smoking status, the prevalence of HPV16,18 in oropharyngeal cancer patients was highest in Whites (61.1%), followed by 58.0% in Blacks and 25.2% in Asians (P <0.0001). There was no statistically significant difference in HPV16,18 prevalence in nonoropharyngeal cancer by race (P = 0.682). With regard to the pattern of HPV16,18 status and p16 expression, White patients had the highest proportion of HPV16,18+/p16+ oropharyngeal cancer (52.3%), while Asians and Blacks had significantly lower proportions (23.0 and 22.6%, respectively) [P <0.0001]. Our findings suggest that the pattern of HPV16,18 status and p16 expression in oropharyngeal cancer appears to differ by race and this may contribute to survival disparities.
AB - The landscape of human papillomavirus (HPV) infection in racial/ethnic subgroups of head and neck cancer (HNC) patients has not been evaluated carefully. In this study, a meta-analysis examined the prevalence of HPV in HNC patients of African ancestry. Additionally, a pooled analysis of subject- level data was also performed to investigate HPV prevalence and patterns of p16 (CDNK2A) expression amongst different racial groups. Eighteen publications (N = 798 Black HNC patients) were examined in the meta-analysis, and the pooled analysis included 29 datasets comprised of 3129 HNC patients of diverse racial/ethnic background. The meta-analysis revealed that the prevalence of HPV16 was higher among Blacks with oropharyngeal cancer than Blacks with non-oropharyngeal cancer. However, there was great heterogeneity observed among studies (Q test P <0.0001). In the pooled analysis, after adjusting for each study, year of diagnosis, age, gender and smoking status, the prevalence of HPV16,18 in oropharyngeal cancer patients was highest in Whites (61.1%), followed by 58.0% in Blacks and 25.2% in Asians (P <0.0001). There was no statistically significant difference in HPV16,18 prevalence in nonoropharyngeal cancer by race (P = 0.682). With regard to the pattern of HPV16,18 status and p16 expression, White patients had the highest proportion of HPV16,18+/p16+ oropharyngeal cancer (52.3%), while Asians and Blacks had significantly lower proportions (23.0 and 22.6%, respectively) [P <0.0001]. Our findings suggest that the pattern of HPV16,18 status and p16 expression in oropharyngeal cancer appears to differ by race and this may contribute to survival disparities.
KW - SQUAMOUS-CELL CARCINOMA
KW - HUMAN-PAPILLOMAVIRUS TYPE-16
KW - POTENTIALLY MALIGNANT DISORDERS
KW - E6/E7 MESSENGER-RNA
KW - EPSTEIN-BARR-VIRUS
KW - OROPHARYNGEAL CANCER
KW - AFRICAN-AMERICANS
KW - IMPROVED SURVIVAL
KW - UNITED-STATES
KW - P16 IMMUNOHISTOCHEMISTRY
U2 - 10.1093/carcin/bgw203
DO - 10.1093/carcin/bgw203
M3 - Article
C2 - 28025390
SN - 0143-3334
VL - 38
SP - 218
EP - 229
JO - Carcinogenesis
JF - Carcinogenesis
IS - 2
ER -