Preoperative breast radiation therapy: Indications and perspectives

S. V. Lightowlers; L. J. Boersma; A. Fourquet; Y. M. Kirova; B. V. Offersen; P. Poortmans; A. N. Scholten; N. Somaiah; C. E. Coles

doi:10.1016/j.ejca.2017.06.014

Preoperative breast radiation therapy: Indications and perspectives

S. V. Lightowlers^*, L. J. Boersma, A. Fourquet, Y. M. Kirova, B. V. Offersen, P. Poortmans, A. N. Scholten, N. Somaiah, C. E. Coles

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Preoperative breast radiation therapy (RT) is not a new concept, but older studies failed to change practice. More recently, there has been interest in revisiting preoperative RT using modern techniques. This current perspective discusses the indications, summarises the published literature and then highlights current clinical trials, with particular attention to combining with novel drugs and optimising associated translational research. (C) 2017 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	184-192
Number of pages	9
Journal	European Journal of Cancer
Volume	82
DOIs	https://doi.org/10.1016/j.ejca.2017.06.014
Publication status	Published - Sept 2017

Keywords

Preoperative breast radiation therapy
IMRT
Translational research
INTENSITY-MODULATED RADIOTHERAPY
POSTMASTECTOMY RADIOTHERAPY
NEOADJUVANT CHEMOTHERAPY
CONCURRENT PACLITAXEL
PATHOLOGICAL RESPONSE
CLINICAL DEVELOPMENT
PHASE-II
CANCER
TRIAL
IRRADIATION

Access to Document

10.1016/j.ejca.2017.06.014

Cite this

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title = "Preoperative breast radiation therapy: Indications and perspectives",

abstract = "Preoperative breast radiation therapy (RT) is not a new concept, but older studies failed to change practice. More recently, there has been interest in revisiting preoperative RT using modern techniques. This current perspective discusses the indications, summarises the published literature and then highlights current clinical trials, with particular attention to combining with novel drugs and optimising associated translational research. (C) 2017 Elsevier Ltd. All rights reserved.",

keywords = "Preoperative breast radiation therapy, IMRT, Translational research, INTENSITY-MODULATED RADIOTHERAPY, POSTMASTECTOMY RADIOTHERAPY, NEOADJUVANT CHEMOTHERAPY, CONCURRENT PACLITAXEL, PATHOLOGICAL RESPONSE, CLINICAL DEVELOPMENT, PHASE-II, CANCER, TRIAL, IRRADIATION",

author = "Lightowlers, {S. V.} and Boersma, {L. J.} and A. Fourquet and Kirova, {Y. M.} and Offersen, {B. V.} and P. Poortmans and Scholten, {A. N.} and N. Somaiah and Coles, {C. E.}",

year = "2017",

month = sep,

doi = "10.1016/j.ejca.2017.06.014",

language = "English",

volume = "82",

pages = "184--192",

journal = "European Journal of Cancer",

issn = "0959-8049",

publisher = "ELSEVIER SCI LTD",

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T1 - Preoperative breast radiation therapy

T2 - Indications and perspectives

AU - Lightowlers, S. V.

AU - Boersma, L. J.

AU - Fourquet, A.

AU - Kirova, Y. M.

AU - Offersen, B. V.

AU - Poortmans, P.

AU - Scholten, A. N.

AU - Somaiah, N.

AU - Coles, C. E.

PY - 2017/9

Y1 - 2017/9

N2 - Preoperative breast radiation therapy (RT) is not a new concept, but older studies failed to change practice. More recently, there has been interest in revisiting preoperative RT using modern techniques. This current perspective discusses the indications, summarises the published literature and then highlights current clinical trials, with particular attention to combining with novel drugs and optimising associated translational research. (C) 2017 Elsevier Ltd. All rights reserved.

AB - Preoperative breast radiation therapy (RT) is not a new concept, but older studies failed to change practice. More recently, there has been interest in revisiting preoperative RT using modern techniques. This current perspective discusses the indications, summarises the published literature and then highlights current clinical trials, with particular attention to combining with novel drugs and optimising associated translational research. (C) 2017 Elsevier Ltd. All rights reserved.

KW - Preoperative breast radiation therapy

KW - IMRT

KW - Translational research

KW - INTENSITY-MODULATED RADIOTHERAPY

KW - POSTMASTECTOMY RADIOTHERAPY

KW - NEOADJUVANT CHEMOTHERAPY

KW - CONCURRENT PACLITAXEL

KW - PATHOLOGICAL RESPONSE

KW - CLINICAL DEVELOPMENT

KW - PHASE-II

KW - CANCER

KW - TRIAL

KW - IRRADIATION

U2 - 10.1016/j.ejca.2017.06.014

DO - 10.1016/j.ejca.2017.06.014

M3 - Article

C2 - 28692950

SN - 0959-8049

VL - 82

SP - 184

EP - 192

JO - European Journal of Cancer

JF - European Journal of Cancer

ER -