TY - JOUR
T1 - Prenatal stress reduces S100B in the neonatal rat hippocampus
AU - van den Hove, D.L.
AU - Steinbusch, H.W.M.
AU - Bruschettini, M.
AU - Gazzolo, D.
AU - Frulio, R.
AU - Scheepens, A.
AU - Prickaerts, J.H.H.J.
AU - Blanco, C.E.
PY - 2006/1/1
Y1 - 2006/1/1
N2 - Prenatal stress has been shown to disturb neonatal rat brain development. The astroglial-specific neurotrophic factor S100B is known to play an important role in normal brain development. In the present study, we investigated the effects of prenatal stress on S100B concentrations in the hippocampus of I-day-old Fischer 344 rats. Overall, prenatal stress resulted in a 25% reduction in hippocampal S100B content. Further, male hippocampal S100B content was negatively correlated with plasma corticosterone levels. Positive correlations were found between female S100B levels and fetal growth, and hippocampal brain-derived neurotrophic factor content. In conclusion, the observed reduction in neonatal hippocampal S100B levels, as a consequence of prenatal stress, may be involved in affecting postnatal brain development.
AB - Prenatal stress has been shown to disturb neonatal rat brain development. The astroglial-specific neurotrophic factor S100B is known to play an important role in normal brain development. In the present study, we investigated the effects of prenatal stress on S100B concentrations in the hippocampus of I-day-old Fischer 344 rats. Overall, prenatal stress resulted in a 25% reduction in hippocampal S100B content. Further, male hippocampal S100B content was negatively correlated with plasma corticosterone levels. Positive correlations were found between female S100B levels and fetal growth, and hippocampal brain-derived neurotrophic factor content. In conclusion, the observed reduction in neonatal hippocampal S100B levels, as a consequence of prenatal stress, may be involved in affecting postnatal brain development.
U2 - 10.1097/01.wnr.0000223391.74575.c9
DO - 10.1097/01.wnr.0000223391.74575.c9
M3 - Article
C2 - 16791107
SN - 0959-4965
VL - 17
SP - 1077
EP - 1080
JO - Neuroreport
JF - Neuroreport
IS - 10
ER -