Pregnancy derived products for treatment of perinatal brain injuries

Martin M. Müller

doi:10.26481/dis.20170224mm

Pregnancy derived products for treatment of perinatal brain injuries

Martin M. Müller

Research output: Thesis › Doctoral Thesis › External prepared

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Abstract

In this thesis potential treatment options to reduce the burden of brain injuries to immature infants were investigated. Müller investigated the feasibility and protective capacity of pregnancy derived products such as: stem calls: Wharton`s Jelly derived MSCs (WJ-MSCs), 17β-Estradiol supplementation, and synthetic PreImplantation Factor (sPIF) in the context of translational research. It was discovered that these products protect the immature brain after injury in animal models. Multiple novel mechanisms were discovered. These results represent an important step towards tackling perinatal brain injuries, a disease which have been currently unmet. Importantly, clinical trials can be envisioned.

Original language	English
Awarding Institution	Maastricht University
Supervisors/Advisors	Kramer, Boris, Supervisor Surbek, D., Supervisor, External person Wolfs, Tim, Co-Supervisor Gavilanes, A.D.W., Co-Supervisor
Award date	24 Feb 2017
Place of Publication	Maastricht
Publisher	Maastricht University
Print ISBNs	9789461596666
DOIs	https://doi.org/10.26481/dis.20170224mm
Publication status	Published - 2017

Keywords

immature infants
brain injury
treatment

Access to Document

10.26481/dis.20170224mm

Full textFinal published version, 3.07 MB
AbstractFinal published version, 69.3 KB
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Cite this

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