Predictive value for cardiovascular events of common carotid intima media thickness and its rate of change in individuals at high cardiovascular risk: Results from the PROGIMT collaboration

Matthias W. Lorenz*, Lu Gao, Kathrin Ziegelbauer, Giuseppe Danilo Norata, Jean Philippe Empana, Irene Schmidtmann, Hung-Ju Lin, Stela McLachlan, Lena Bokemark, Kimmo Ronkainen, Mauro Amato, Ulf Schminke, Sathanur R. Srinivasan, Lars Lind, Shuhei Okazaki, Coen D. A. Stehouwer, Peter Willeit, Joseph F. Polak, Helmuth Steinmetz, Dirk SanderHolger Poppert, Moise Desvarieux, M. Arfan Ikram, Stein Harald Johnsen, Daniel Staub, Cesare R. Sirtori, Bernhard Igiseder, Oscar Beloqui, Gunnar Engstrom, Alfonso Friera, Francesco Rozza, Wuxiang Xie, Grace Parraga, Liliana Grigore, Matthieu Plichart, Stefan Blankenberg, Ta-Chen Su, Caroline Schmidt, Tomi-Pekka Tuomainen, Fabrizio Veglia, Henry Volzke, Giel Nijpels, Johann Willeit, Ralph L. Sacco, Oscar H. Franco, Heiko Uthoff, Bo Hedblad, Carmen Suarez, Raffaele Izzo, Jing Liu, Dong Zhao, Thapat Wannarong, Alberico Catapano, Pierre Ducimetiere, Christine Espinola-Klein, Kuo-Liong Chien, Jackie F. Price, Goren Bergstrom, Jussi Kauhanen, Elena Tremoli, Marcus Dorr, Gerald Berenson, Kazuo Kitagawa, Jaqueline M. Dekker, Stefan Kiechl, Matthias Sitzer, Horst Bickel, Tatjana Rundek, Albert Hofman, Ellisiv B. Mathiesen, Samuela Castelnuovo, Manuel F. Landecho, Maria Rosvall, Rafael Gabriel, Nicola de Luca, Damiano Baldassarre, Maryam Kavousi, Eric de Groot, Michiel L. Bots, David N. Yanez, Simon G. Thompson, PROG-IMT Study Grp

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Aims Carotid intima media thickness (CIMT) predicts cardiovascular (CVD) events, but the predictive value of CIMT change is debated. We assessed the relation between CIMT change and events in individuals at high cardiovascular risk. Methods and results From 31 cohorts with two CIMT scans (total n = 89070) on average 3.6 years apart and clinical follow-up, subcohorts were drawn: (A) individuals with at least 3 cardiovascular risk factors without previous CVD events, (B) individuals with carotid plaques without previous CVD events, and (C) individuals with previous CVD events. Cox regression models were fit to estimate the hazard ratio (HR) of the combined endpoint (myocardial infarction, stroke or vascular death) per standard deviation (SD) of CIMT change, adjusted for CVD risk factors. These HRs were pooled across studies. In groups A, B and C we observed 3483, 2845 and 1165 endpoint events, respectively. Average common CIMT was 0.79mm (SD 0.16mm), and annual common CIMT change was 0.01mm (SD 0.07mm), both in group A. The pooled HR per SD of annual common CIMT change (0.02 to 0.43mm) was 0.99 (95% confidence interval: 0.95-1.02) in group A, 0.98 (0.93-1.04) in group B, and 0.95 (0.89-1.04) in group C. The HR per SD of common CIMT (average of the first and the second CIMT scan, 0.09 to 0.75mm) was 1.15 (1.07-1.23) in group A, 1.13 (1.05-1.22) in group B, and 1.12 (1.05-1.20) in group C. Conclusions We confirm that common CIMT is associated with future CVD events in individuals at high risk. CIMT change does not relate to future event risk in high-risk individuals.
Original languageEnglish
Article numbere0191172
Number of pages19
JournalPLOS ONE
Volume13
Issue number4
DOIs
Publication statusPublished - 12 Apr 2018

Keywords

  • ARTERY INTIMA
  • MYOCARDIAL-INFARCTION
  • ATHEROSCLEROSIS RISK
  • FOLLOW-UP
  • METABOLIC SYNDROME
  • HYPERTENSIVE MEN
  • VASCULAR RISK
  • PROGRESSION
  • POPULATION
  • DISEASE
  • Prognosis
  • Carotid Intima-Media Thickness
  • Humans
  • Intersectoral Collaboration
  • Middle Aged
  • Risk Factors
  • Male
  • Female
  • Aged
  • Cardiovascular Diseases/diagnosis

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