Abstract
Background: Patients undergoing elective electrical cardioversion (ECV) for atrial fibrillation have a temporarily increased risk of thromboembolism. Current guidelines recommend adequate anticoagulation for >= 3 consecutive weeks precardioversion, i.e. consecutive INR values 2.0-3.0 in patients with vitamin K antagonists (VKA). We aimed to evaluate the occurrence and impact of subtherapeutic INRs precardioversion and to study factors associated with these unwanted fluctuations. Methods: We recruited 346 consecutive patients undergoing elective ECV in the Maastricht University Medical Centre between 2008 and 2013. Predictors of subtherapeutic INR values were identified and incorporated into a logistic regression model. Results: A subtherapeutic INR precardioversion occurred in 55.2% of patients. The only statistically significant predictor was VKA-naivety (Odds Ratio (OR) 4.78, 95% Confidence Interval (CI) 2.67-8.58, p <0.001). In patients with >= 1 subtherapeutic INR precardioversion, time from referral until cardioversion was 91.1 +/- 42.8 days, compared to 41.7 +/- 26.6 days (p <0.001) in patients without subtherapeutic INRs. No thromboembolic events occurred
Original language | English |
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Pages (from-to) | 337-341 |
Journal | International Journal of Cardiology |
Volume | 225 |
DOIs | |
Publication status | Published - 15 Dec 2016 |
Keywords
- Atrial fibrillation
- Cardioversion
- Vitamin K antagonist
- Anticoagulation management