Plasma IL-1 receptor antagonist levels correlate with the development of non-alcoholic steatohepatitis

T. Hendrikx; S.M. Walenbergh; M. Jeurissen; T. Houben; P.J. van Gorp; P.J. Lindsey; Ger H. Koek; S. Kalhan; J. Pihlajamaki; M.H. Hofker; Ronit Shiri-Sverdlov

doi:10.2217/bmm.15.71

Plasma IL-1 receptor antagonist levels correlate with the development of non-alcoholic steatohepatitis

T. Hendrikx, S.M. Walenbergh, M. Jeurissen, T. Houben, P.J. van Gorp, P.J. Lindsey, Ger H. Koek, S. Kalhan, J. Pihlajamaki, M.H. Hofker, Ronit Shiri-Sverdlov^*

^*Corresponding author for this work

Interne Geneeskunde

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

AIM: Nonalcoholic steatohepatitis (NASH) is a liver disease characterized by lipid accumulation and inflammation. Here, we aimed to evaluate plasma IL-1Ra as a marker for NASH and to determine whether diagnosis of NASH can be further improved by adding IL-1Ra measurements. MATERIALS & METHODS: Therefore, plasma concentrations of IL-1Ra were measured from 146 subjects of a biopsy-proven NASH cohort with matched controls. RESULTS: NASH patients had higher levels of plasma IL-1Ra compared with patients with steatosis or healthy controls. CONCLUSION: Our data confirm that IL-1Ra can be a useful tool in the diagnosis of hepatic inflammation and suggest that measuring plasma IL-1Ra levels in addition to ALT will improve the diagnosis for NASH at all stages of the disease.

Original language	English
Pages (from-to)	1301-1309
Number of pages	9
Journal	Biomarkers in Medicine
Volume	9
Issue number	12
DOIs	https://doi.org/10.2217/bmm.15.71
Publication status	Published - 1 Jan 2015

Keywords

diagnosis
hepatic inflammation
IL-1Ra
NASH
FATTY LIVER-DISEASE
NAFLD
MICE
CYTOKERATIN-18
OBESITY

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10.2217/bmm.15.71

Cite this

@article{477845e4694b40c3a14b6dcdfbc3c4d8,

title = "Plasma IL-1 receptor antagonist levels correlate with the development of non-alcoholic steatohepatitis",

abstract = "AIM: Nonalcoholic steatohepatitis (NASH) is a liver disease characterized by lipid accumulation and inflammation. Here, we aimed to evaluate plasma IL-1Ra as a marker for NASH and to determine whether diagnosis of NASH can be further improved by adding IL-1Ra measurements. MATERIALS & METHODS: Therefore, plasma concentrations of IL-1Ra were measured from 146 subjects of a biopsy-proven NASH cohort with matched controls. RESULTS: NASH patients had higher levels of plasma IL-1Ra compared with patients with steatosis or healthy controls. CONCLUSION: Our data confirm that IL-1Ra can be a useful tool in the diagnosis of hepatic inflammation and suggest that measuring plasma IL-1Ra levels in addition to ALT will improve the diagnosis for NASH at all stages of the disease.",

keywords = "diagnosis, hepatic inflammation, IL-1Ra, NASH, FATTY LIVER-DISEASE, NAFLD, MICE, CYTOKERATIN-18, OBESITY",

author = "T. Hendrikx and S.M. Walenbergh and M. Jeurissen and T. Houben and {van Gorp}, P.J. and P.J. Lindsey and Koek, {Ger H.} and S. Kalhan and J. Pihlajamaki and M.H. Hofker and Ronit Shiri-Sverdlov",

year = "2015",

month = jan,

day = "1",

doi = "10.2217/bmm.15.71",

language = "English",

volume = "9",

pages = "1301--1309",

journal = "Biomarkers in Medicine",

issn = "1752-0363",

publisher = "Future Medicine Ltd.",

number = "12",

}

TY - JOUR

T1 - Plasma IL-1 receptor antagonist levels correlate with the development of non-alcoholic steatohepatitis

AU - Hendrikx, T.

AU - Walenbergh, S.M.

AU - Jeurissen, M.

AU - Houben, T.

AU - van Gorp, P.J.

AU - Lindsey, P.J.

AU - Koek, Ger H.

AU - Kalhan, S.

AU - Pihlajamaki, J.

AU - Hofker, M.H.

AU - Shiri-Sverdlov, Ronit

PY - 2015/1/1

Y1 - 2015/1/1

N2 - AIM: Nonalcoholic steatohepatitis (NASH) is a liver disease characterized by lipid accumulation and inflammation. Here, we aimed to evaluate plasma IL-1Ra as a marker for NASH and to determine whether diagnosis of NASH can be further improved by adding IL-1Ra measurements. MATERIALS & METHODS: Therefore, plasma concentrations of IL-1Ra were measured from 146 subjects of a biopsy-proven NASH cohort with matched controls. RESULTS: NASH patients had higher levels of plasma IL-1Ra compared with patients with steatosis or healthy controls. CONCLUSION: Our data confirm that IL-1Ra can be a useful tool in the diagnosis of hepatic inflammation and suggest that measuring plasma IL-1Ra levels in addition to ALT will improve the diagnosis for NASH at all stages of the disease.

AB - AIM: Nonalcoholic steatohepatitis (NASH) is a liver disease characterized by lipid accumulation and inflammation. Here, we aimed to evaluate plasma IL-1Ra as a marker for NASH and to determine whether diagnosis of NASH can be further improved by adding IL-1Ra measurements. MATERIALS & METHODS: Therefore, plasma concentrations of IL-1Ra were measured from 146 subjects of a biopsy-proven NASH cohort with matched controls. RESULTS: NASH patients had higher levels of plasma IL-1Ra compared with patients with steatosis or healthy controls. CONCLUSION: Our data confirm that IL-1Ra can be a useful tool in the diagnosis of hepatic inflammation and suggest that measuring plasma IL-1Ra levels in addition to ALT will improve the diagnosis for NASH at all stages of the disease.

KW - diagnosis

KW - hepatic inflammation

KW - IL-1Ra

KW - NASH

KW - FATTY LIVER-DISEASE

KW - NAFLD

KW - MICE

KW - CYTOKERATIN-18

KW - OBESITY

U2 - 10.2217/bmm.15.71

DO - 10.2217/bmm.15.71

M3 - Article

SN - 1752-0363

VL - 9

SP - 1301

EP - 1309

JO - Biomarkers in Medicine

JF - Biomarkers in Medicine

IS - 12

ER -