Phosphorylcholine antibodies are diminished in ANCA-associated vasculitis

Benjamin Wilde; Marjan Slot; Pieter van Paassen; Ruud Theunissen; Michael Kemna; Oliver Witzke; Jan Willem Cohen Tervaert

doi:10.1111/eci.12457

Phosphorylcholine antibodies are diminished in ANCA-associated vasculitis

Benjamin Wilde, Marjan Slot, Pieter van Paassen, Ruud Theunissen, Michael Kemna, Oliver Witzke, Jan Willem Cohen Tervaert^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Background/AimANCA-associated (AAV) vasculitis is an autoimmune small-vessel vasculitis and may be associated with accelerated atherosclerosis as suggested by current literature. Antibodies against oxidized lipoproteins (OxLDL) and phosphorylcholine (Pc) protect from atherosclerosis. This study characterizes these antibodies in AAV. MethodsPc- and anti-OxLDL antibodies were determined in sera of 39 AAV patients and 44 healthy controls (HC). Intima-media thickness (IMT, carotids) and pulse wave velocity (PWV, A. femoralis) were measured. ResultsPc-/OxLDL IgM antibodies were significantly reduced in AAV. IMT and PWV were negatively associated with anti-Pc antibodies in HC only. ConclusionAtheroprotective anti-Pc/anti-OxLDL antibodies are significantly reduced in AAV possibly explaining accelerated atherosclerosis in vasculitis patients.

Original language	English
Pages (from-to)	686-691
Journal	European Journal of Clinical Investigation
Volume	45
Issue number	7
DOIs	https://doi.org/10.1111/eci.12457
Publication status	Published - Jul 2015

Keywords

ANCA
OxLDL
PcLDL
vasculitis

Access to Document

10.1111/eci.12457

Cite this

@article{770e2ceffbf84313a6027577f913ecef,

title = "Phosphorylcholine antibodies are diminished in ANCA-associated vasculitis",

abstract = "Background/AimANCA-associated (AAV) vasculitis is an autoimmune small-vessel vasculitis and may be associated with accelerated atherosclerosis as suggested by current literature. Antibodies against oxidized lipoproteins (OxLDL) and phosphorylcholine (Pc) protect from atherosclerosis. This study characterizes these antibodies in AAV. MethodsPc- and anti-OxLDL antibodies were determined in sera of 39 AAV patients and 44 healthy controls (HC). Intima-media thickness (IMT, carotids) and pulse wave velocity (PWV, A. femoralis) were measured. ResultsPc-/OxLDL IgM antibodies were significantly reduced in AAV. IMT and PWV were negatively associated with anti-Pc antibodies in HC only. ConclusionAtheroprotective anti-Pc/anti-OxLDL antibodies are significantly reduced in AAV possibly explaining accelerated atherosclerosis in vasculitis patients.",

keywords = "ANCA, OxLDL, PcLDL, vasculitis",

author = "Benjamin Wilde and Marjan Slot and {van Paassen}, Pieter and Ruud Theunissen and Michael Kemna and Oliver Witzke and Tervaert, {Jan Willem Cohen}",

year = "2015",

month = jul,

doi = "10.1111/eci.12457",

language = "English",

volume = "45",

pages = "686--691",

journal = "European Journal of Clinical Investigation",

issn = "0014-2972",

publisher = "Wiley",

number = "7",

}

TY - JOUR

T1 - Phosphorylcholine antibodies are diminished in ANCA-associated vasculitis

AU - Wilde, Benjamin

AU - Slot, Marjan

AU - van Paassen, Pieter

AU - Theunissen, Ruud

AU - Kemna, Michael

AU - Witzke, Oliver

AU - Tervaert, Jan Willem Cohen

PY - 2015/7

Y1 - 2015/7

N2 - Background/AimANCA-associated (AAV) vasculitis is an autoimmune small-vessel vasculitis and may be associated with accelerated atherosclerosis as suggested by current literature. Antibodies against oxidized lipoproteins (OxLDL) and phosphorylcholine (Pc) protect from atherosclerosis. This study characterizes these antibodies in AAV. MethodsPc- and anti-OxLDL antibodies were determined in sera of 39 AAV patients and 44 healthy controls (HC). Intima-media thickness (IMT, carotids) and pulse wave velocity (PWV, A. femoralis) were measured. ResultsPc-/OxLDL IgM antibodies were significantly reduced in AAV. IMT and PWV were negatively associated with anti-Pc antibodies in HC only. ConclusionAtheroprotective anti-Pc/anti-OxLDL antibodies are significantly reduced in AAV possibly explaining accelerated atherosclerosis in vasculitis patients.

AB - Background/AimANCA-associated (AAV) vasculitis is an autoimmune small-vessel vasculitis and may be associated with accelerated atherosclerosis as suggested by current literature. Antibodies against oxidized lipoproteins (OxLDL) and phosphorylcholine (Pc) protect from atherosclerosis. This study characterizes these antibodies in AAV. MethodsPc- and anti-OxLDL antibodies were determined in sera of 39 AAV patients and 44 healthy controls (HC). Intima-media thickness (IMT, carotids) and pulse wave velocity (PWV, A. femoralis) were measured. ResultsPc-/OxLDL IgM antibodies were significantly reduced in AAV. IMT and PWV were negatively associated with anti-Pc antibodies in HC only. ConclusionAtheroprotective anti-Pc/anti-OxLDL antibodies are significantly reduced in AAV possibly explaining accelerated atherosclerosis in vasculitis patients.

KW - ANCA

KW - OxLDL

KW - PcLDL

KW - vasculitis

U2 - 10.1111/eci.12457

DO - 10.1111/eci.12457

M3 - Article

C2 - 25940757

SN - 0014-2972

VL - 45

SP - 686

EP - 691

JO - European Journal of Clinical Investigation

JF - European Journal of Clinical Investigation

IS - 7

ER -