TY - JOUR
T1 - Performance and complications of lumbar puncture in memory clinics: Results of the multicenter lumbar puncture feasibility study
AU - Duits, Flora H.
AU - Martinez-Lage, Pablo
AU - Paquet, Claire
AU - Engelborghs, Sebastiaan
AU - Lleo, Alberto
AU - Hausner, Lucrezia
AU - Molinuevo, Jose L.
AU - Stomrud, Erik
AU - Farotti, Lucia
AU - Ramakers, Inez H. G. B.
AU - Tsolaki, Magda
AU - Skarsgard, Constance
AU - Astrand, Ragnar
AU - Wallin, Anders
AU - Vyhnalek, Martin
AU - Holmber-Clausen, Marie
AU - Forlenza, Orestes V.
AU - Ghezzi, Laura
AU - Ingelsson, Martin
AU - Hoff, Erik I.
AU - Roks, Gerwin
AU - de Mendonca, Alexandre
AU - Papma, Janne M.
AU - Izagirre, Andrea
AU - Taga, Mariko
AU - Struyfs, Hanne
AU - Alcolea, Daniel A.
AU - Froelich, Lutz
AU - Balasa, Mircea
AU - Minthon, Lennart
AU - Twisk, Jos W. R.
AU - Persson, Staffan
AU - Zetterberg, Henrik
AU - van der Flier, Wiesje M.
AU - Teunissen, Charlotte E.
AU - Scheltens, Philip
AU - Blennow, Kaj
PY - 2016/2
Y1 - 2016/2
N2 - Introduction: Lumbar puncture (LP) is increasingly performed in memory clinics. We investigated patient-acceptance of LP, incidence of and risk factors for post-LP complications in memory clinic populations. Methods: We prospectively enrolled 3868 patients (50% women, age 66 +/- 11 years, mini mental state examination 25 +/- 5) at 23 memory clinics. We used logistic regression analysis using generalized estimated equations to investigate risk factors for post-LP complications, such as typical postlumbar puncture headache (PLPH) and back pain. Results: A total of 1065 patients (31%) reported post-LP complaints; 589 patients (17%) reported back pain, 649 (19%) headache, of which 296 (9%) reported typical PLPH. Only few patients needed medical intervention: 11 (0.3%) received a blood patch, 23 (0.7%) were hospitalized. The most important risk factor for PLPH was medical history of headache. An atraumatic needle and age >65 years were preventive. Gender, rest after LP, or volume of cerebrospinal fluid had no effect. Discussions: The overall risk of complications is relatively low. If risk factors shown in this study are taken into account, LPs can be safely performed in memory clinics.
AB - Introduction: Lumbar puncture (LP) is increasingly performed in memory clinics. We investigated patient-acceptance of LP, incidence of and risk factors for post-LP complications in memory clinic populations. Methods: We prospectively enrolled 3868 patients (50% women, age 66 +/- 11 years, mini mental state examination 25 +/- 5) at 23 memory clinics. We used logistic regression analysis using generalized estimated equations to investigate risk factors for post-LP complications, such as typical postlumbar puncture headache (PLPH) and back pain. Results: A total of 1065 patients (31%) reported post-LP complaints; 589 patients (17%) reported back pain, 649 (19%) headache, of which 296 (9%) reported typical PLPH. Only few patients needed medical intervention: 11 (0.3%) received a blood patch, 23 (0.7%) were hospitalized. The most important risk factor for PLPH was medical history of headache. An atraumatic needle and age >65 years were preventive. Gender, rest after LP, or volume of cerebrospinal fluid had no effect. Discussions: The overall risk of complications is relatively low. If risk factors shown in this study are taken into account, LPs can be safely performed in memory clinics.
KW - Lumbar puncture
KW - Cognitive disorders
KW - Alzheimer's disease
KW - Memory clinic
KW - Post-LP complications
KW - Post-LP headache
KW - Multicenter study on LP feasibility
U2 - 10.1016/j.jalz.2015.08.003
DO - 10.1016/j.jalz.2015.08.003
M3 - Article
C2 - 26368321
SN - 1552-5260
VL - 12
SP - 154
EP - 163
JO - Alzheimer's & Dementia
JF - Alzheimer's & Dementia
IS - 2
ER -