Abstract
Ovarian cancer risk factors differ by histotype; however, within subtype, there is substantial variability in outcomes. We hypothesized that risk factor profiles may influence tumor aggressiveness, defined by time between diagnosis and death, independent of histology. Among 1.3 million women from 21 prospective cohorts, 4,584 invasive epithelial ovarian cancers were identified and classified as highly aggressive (death in = 35 vs. 20 to <25 kg/m(2), 1.93 [1.46-2.56] and current smoking (vs. never, 1.30 [1.07-1.57]) were associated with increased risk of highly aggressive disease. Results were similar within histotypes. Ovarian cancer risk factors may be directly associated with subtypes defined by tumor aggressiveness, rather than through differential effects on histology. Studies to assess biological pathways are warranted.
Original language | English |
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Pages (from-to) | 58-69 |
Number of pages | 12 |
Journal | International Journal of Cancer |
Volume | 145 |
Issue number | 1 |
DOIs | |
Publication status | Published - 1 Jul 2019 |
Keywords
- ASSOCIATION
- BREAST-CANCER
- CHEMOTHERAPY
- ENDOMETRIAL CANCER
- OBESITY
- POSTMENOPAUSAL WOMEN
- PROLACTIN LEVELS
- SEX STEROIDS
- SMOKING
- SURVIVAL
- aggressiveness
- ovarian cancer
- prospective cohort
- risk factors
- subtypes