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Optimizing BOLD sensitivity in the 7T Human Connectome Project resting-state fMRI protocol using plug-and-play parallel transmission

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Optimizing BOLD sensitivity in the 7T Human Connectome Project resting-state fMRI protocol using plug-and-play parallel transmission. / Gras, Vincent; Poser, Benedikt A; Wu, Xiaoping; Tomi-Tricot, Raphal; Boulant, Nicolas.

In: Neuroimage, Vol. 195, 15.07.2019, p. 1-10.

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@article{34e6e06ea8e94e9bb57a4bd24dc2472f,
title = "Optimizing BOLD sensitivity in the 7T Human Connectome Project resting-state fMRI protocol using plug-and-play parallel transmission",
abstract = "The Human Connectome Project (HCP) has a 7T component that aims to study the human brain's organization and function with high spatial and temporal resolution fMRI and diffusion-weighted acquisitions. For whole brain applications at 7T, a major weakness however remains the heterogeneity of the radiofrequency transmission field (B1+ ), which prevents from achieving an optimal signal and contrast homogeneously throughout the brain. In this work, we use parallel transmission (pTX) Universal Pulses (UP) to improve the flip angle homogeneity and demonstrate their application to highly accelerated multi-band EPI (MB5 and GRAPPA2, as prescribed in the 7T HCP protocol) sequence, but also to acquire at 7T B1+ -artefact-free T1 - and T2 -weighted anatomical scans used in the pre-processing pipeline of the HCP protocol. As compared to typical implementations of pTX, the proposed solution is fully operator-independent and allows {"}plug and play{"} exploitation of the benefits offered by multi-channel transmission. Validation in five healthy adults shows that the proposed technique achieves a flip angle homogeneity comparable to that of a clinical 3 T system. Compared to standard single-channel transmission, the use of UPs at 7T yielded up to a two-fold increase of the temporal signal-to-noise ratio in the temporal lobes as well as improved detection of functional connectivity in the brain regions most strongly affected by B1+ inhomogeneity.",
keywords = "ABSORPTION RATE, CALIBRATION, Calibration, DESIGN, EXCITATION, HUMAN BRAIN, Human connectome project, INHOMOGENEITY, Multi-band EPI, OPTIMIZATION, Parallel transmission, REGISTRATION, RF PULSES, RF shimming, TESLA, Ultra-high field, Universal pulse",
author = "Vincent Gras and Poser, {Benedikt A} and Xiaoping Wu and Raphal Tomi-Tricot and Nicolas Boulant",
note = "Copyright {\circledC} 2019. Published by Elsevier Inc.",
year = "2019",
month = "7",
day = "15",
doi = "10.1016/j.neuroimage.2019.03.040",
language = "English",
volume = "195",
pages = "1--10",
journal = "Neuroimage",
issn = "1053-8119",
publisher = "Elsevier Science",

}

RIS

TY - JOUR

T1 - Optimizing BOLD sensitivity in the 7T Human Connectome Project resting-state fMRI protocol using plug-and-play parallel transmission

AU - Gras, Vincent

AU - Poser, Benedikt A

AU - Wu, Xiaoping

AU - Tomi-Tricot, Raphal

AU - Boulant, Nicolas

N1 - Copyright © 2019. Published by Elsevier Inc.

PY - 2019/7/15

Y1 - 2019/7/15

N2 - The Human Connectome Project (HCP) has a 7T component that aims to study the human brain's organization and function with high spatial and temporal resolution fMRI and diffusion-weighted acquisitions. For whole brain applications at 7T, a major weakness however remains the heterogeneity of the radiofrequency transmission field (B1+ ), which prevents from achieving an optimal signal and contrast homogeneously throughout the brain. In this work, we use parallel transmission (pTX) Universal Pulses (UP) to improve the flip angle homogeneity and demonstrate their application to highly accelerated multi-band EPI (MB5 and GRAPPA2, as prescribed in the 7T HCP protocol) sequence, but also to acquire at 7T B1+ -artefact-free T1 - and T2 -weighted anatomical scans used in the pre-processing pipeline of the HCP protocol. As compared to typical implementations of pTX, the proposed solution is fully operator-independent and allows "plug and play" exploitation of the benefits offered by multi-channel transmission. Validation in five healthy adults shows that the proposed technique achieves a flip angle homogeneity comparable to that of a clinical 3 T system. Compared to standard single-channel transmission, the use of UPs at 7T yielded up to a two-fold increase of the temporal signal-to-noise ratio in the temporal lobes as well as improved detection of functional connectivity in the brain regions most strongly affected by B1+ inhomogeneity.

AB - The Human Connectome Project (HCP) has a 7T component that aims to study the human brain's organization and function with high spatial and temporal resolution fMRI and diffusion-weighted acquisitions. For whole brain applications at 7T, a major weakness however remains the heterogeneity of the radiofrequency transmission field (B1+ ), which prevents from achieving an optimal signal and contrast homogeneously throughout the brain. In this work, we use parallel transmission (pTX) Universal Pulses (UP) to improve the flip angle homogeneity and demonstrate their application to highly accelerated multi-band EPI (MB5 and GRAPPA2, as prescribed in the 7T HCP protocol) sequence, but also to acquire at 7T B1+ -artefact-free T1 - and T2 -weighted anatomical scans used in the pre-processing pipeline of the HCP protocol. As compared to typical implementations of pTX, the proposed solution is fully operator-independent and allows "plug and play" exploitation of the benefits offered by multi-channel transmission. Validation in five healthy adults shows that the proposed technique achieves a flip angle homogeneity comparable to that of a clinical 3 T system. Compared to standard single-channel transmission, the use of UPs at 7T yielded up to a two-fold increase of the temporal signal-to-noise ratio in the temporal lobes as well as improved detection of functional connectivity in the brain regions most strongly affected by B1+ inhomogeneity.

KW - ABSORPTION RATE

KW - CALIBRATION

KW - Calibration

KW - DESIGN

KW - EXCITATION

KW - HUMAN BRAIN

KW - Human connectome project

KW - INHOMOGENEITY

KW - Multi-band EPI

KW - OPTIMIZATION

KW - Parallel transmission

KW - REGISTRATION

KW - RF PULSES

KW - RF shimming

KW - TESLA

KW - Ultra-high field

KW - Universal pulse

U2 - 10.1016/j.neuroimage.2019.03.040

DO - 10.1016/j.neuroimage.2019.03.040

M3 - Article

VL - 195

SP - 1

EP - 10

JO - Neuroimage

T2 - Neuroimage

JF - Neuroimage

SN - 1053-8119

ER -