Opposing Age-Related Trends in Absolute and Relative Risk of Adverse Health Outcomes Associated With Out-of-Office Blood Pressure

Yan Li, Lutgarde Thijs, Zhen-Yu Zhang, Kei Asayama, Tine W. Hansen, Jose Boggia, Kristina Bjoerklund-Bodegard, Wen-Yi Yang, Teemu J. Niiranen, Angeliki Ntineri, Fang-Fei Wei, Masahiro Kikuya, Takayoshi Ohkubo, Eamon Dolan, Atsushi Hozawa, Ichiro Tsuji, Katarzyna Stolarz-Skrzypek, Qi-Fang Huang, Jesus D. Melgarejo, Valerie TikhonoffSofia Malyutina, Edoardo Casiglia, Yuri Nikitin, Lars Lind, Edgardo Sandoya, Lucas Aparicio, Jessica Barochiner, Natasza Gilis-Malinowska, Krzysztof Narkiewicz, Kalina Kawecka-Jaszcz, Gladys E. Maestre, Antti M. Jula, Jouni K. Johansson, Tatiana Kuznetsova, Jan Filipovsky, George Stergiou, Ji-Guang Wang, Yutaka Imai, Eoin O'Brien, Jan A. Staessen*, International Database on Ambulatory and Home Blood Pressure in Relation to Cardiovascular Outcome Investigators

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Participant-level meta-analyses assessed the age-specific relevance of office blood pressure to cardiovascular complications, but this information is lacking for out-of-office blood pressure. At baseline, daytime ambulatory (n=12 624) or home (n=5297) blood pressure were measured in 17 921 participants (51.3% women; mean age, 54.2 years) from 17 population cohorts. Subsequently, mortality and cardiovascular events were recorded. Using multivariable Cox regression, floating absolute risk was computed across 4 age bands (80 years). Over 236 491 person-years, 3855 people died and 2942 cardiovascular events occurred. From levels as low as 110/65 mm Hg, risk log-linearly increased with higher out-of-office systolic/diastolic blood pressure. From the youngest to the oldest age group, rates expressed per 1000 person-years increased (P

Original languageEnglish
Pages (from-to)1333-1342
Number of pages10
JournalHypertension
Volume74
Issue number6
DOIs
Publication statusPublished - Dec 2019

Keywords

  • BASE-LINE CHARACTERISTICS
  • CARDIOVASCULAR RISK
  • HOME
  • HYPERTENSION
  • INTERNATIONAL DATABASE
  • METAANALYSIS
  • MILLION ADULTS
  • MORTALITY
  • POPULATION
  • PREDICTION
  • STROKE
  • TASK-FORCE
  • ambulatory
  • blood pressure
  • blood pressure monitoring
  • cardiovascular diseases
  • hypertension
  • mortality

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