Occupational exposures and risk of dementia-related mortality in the prospective Netherlands Cohort Study

T. Koeman; L.J. Schouten; P.A. van den Brandt; P. Slottje; A. Huss; S. Peters; H. Kromhout; R. Vermeulen

doi:10.1002/ajim.22462

Occupational exposures and risk of dementia-related mortality in the prospective Netherlands Cohort Study

T. Koeman, L.J. Schouten, P.A. van den Brandt, P. Slottje, A. Huss, S. Peters, H. Kromhout, R. Vermeulen^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

BackgroundOccupational exposures may be associated with non-vascular dementia.

MethodsWe analyzed the effects of occupational exposures to solvents, pesticides, metals, extremely low frequency magnetic fields (ELF-MF), electrical shocks, and diesel motor exhaust on non-vascular dementia related mortality in the Netherlands Cohort Study (NLCS). Exposures were assigned using job-exposure matrices. After 17.3 years of follow-up, 682 male and 870 female cases were available. Analyses were performed using Cox regression.

ResultsOccupational exposure to metals, chlorinated solvents and ELF-MF showed positive associations with non-vascular dementia among men, which seemed driven by metals (hazard ratio ever high vs. background exposure: 1.35 [0.98-1.86]). Pesticide exposure showed statistically significant, inverse associations with non-vascular dementia among men. We found no associations for shocks, aromatic solvents, and diesel motor exhaust.

ConclusionsConsistent positive associations were found between occupational exposure to metals and non-vascular dementia. The finding on pesticides is not supported in the overall literature. Am. J. Ind. Med. 58:625-635, 2015. (c) 2015 Wiley Periodicals, Inc.

Original language	English
Pages (from-to)	625-635
Number of pages	11
Journal	American Journal of Industrial Medicine
Volume	58
Issue number	6
DOIs	https://doi.org/10.1002/ajim.22462
Publication status	Published - Jun 2015

Keywords

cohort
dementia
Alzheimer's disease
occupation
extremely low frequency magnetic fields
pesticides
metals
solvents
diesel motor exhaust
FREQUENCY MAGNETIC-FIELDS
ALZHEIMERS-DISEASE
NEURODEGENERATIVE DISEASES
PESTICIDE EXPOSURE
AIR-POLLUTION
AMYLOID-BETA
WORKERS
POPULATION
COMMUNITY
ALUMINUM

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10.1002/ajim.22462

Cite this

@article{9662e23572e04772ad957254a94b0056,

title = "Occupational exposures and risk of dementia-related mortality in the prospective Netherlands Cohort Study",

abstract = "BackgroundOccupational exposures may be associated with non-vascular dementia.MethodsWe analyzed the effects of occupational exposures to solvents, pesticides, metals, extremely low frequency magnetic fields (ELF-MF), electrical shocks, and diesel motor exhaust on non-vascular dementia related mortality in the Netherlands Cohort Study (NLCS). Exposures were assigned using job-exposure matrices. After 17.3 years of follow-up, 682 male and 870 female cases were available. Analyses were performed using Cox regression.ResultsOccupational exposure to metals, chlorinated solvents and ELF-MF showed positive associations with non-vascular dementia among men, which seemed driven by metals (hazard ratio ever high vs. background exposure: 1.35 [0.98-1.86]). Pesticide exposure showed statistically significant, inverse associations with non-vascular dementia among men. We found no associations for shocks, aromatic solvents, and diesel motor exhaust.ConclusionsConsistent positive associations were found between occupational exposure to metals and non-vascular dementia. The finding on pesticides is not supported in the overall literature. Am. J. Ind. Med. 58:625-635, 2015. (c) 2015 Wiley Periodicals, Inc.",

keywords = "cohort, dementia, Alzheimer's disease, occupation, extremely low frequency magnetic fields, pesticides, metals, solvents, diesel motor exhaust, FREQUENCY MAGNETIC-FIELDS, ALZHEIMERS-DISEASE, NEURODEGENERATIVE DISEASES, PESTICIDE EXPOSURE, AIR-POLLUTION, AMYLOID-BETA, WORKERS, POPULATION, COMMUNITY, ALUMINUM",

author = "T. Koeman and L.J. Schouten and {van den Brandt}, P.A. and P. Slottje and A. Huss and S. Peters and H. Kromhout and R. Vermeulen",

year = "2015",

month = jun,

doi = "10.1002/ajim.22462",

language = "English",

volume = "58",

pages = "625--635",

journal = "American Journal of Industrial Medicine",

issn = "0271-3586",

publisher = "Wiley",

number = "6",

}

TY - JOUR

T1 - Occupational exposures and risk of dementia-related mortality in the prospective Netherlands Cohort Study

AU - Koeman, T.

AU - Schouten, L.J.

AU - van den Brandt, P.A.

AU - Slottje, P.

AU - Huss, A.

AU - Peters, S.

AU - Kromhout, H.

AU - Vermeulen, R.

PY - 2015/6

Y1 - 2015/6

N2 - BackgroundOccupational exposures may be associated with non-vascular dementia.MethodsWe analyzed the effects of occupational exposures to solvents, pesticides, metals, extremely low frequency magnetic fields (ELF-MF), electrical shocks, and diesel motor exhaust on non-vascular dementia related mortality in the Netherlands Cohort Study (NLCS). Exposures were assigned using job-exposure matrices. After 17.3 years of follow-up, 682 male and 870 female cases were available. Analyses were performed using Cox regression.ResultsOccupational exposure to metals, chlorinated solvents and ELF-MF showed positive associations with non-vascular dementia among men, which seemed driven by metals (hazard ratio ever high vs. background exposure: 1.35 [0.98-1.86]). Pesticide exposure showed statistically significant, inverse associations with non-vascular dementia among men. We found no associations for shocks, aromatic solvents, and diesel motor exhaust.ConclusionsConsistent positive associations were found between occupational exposure to metals and non-vascular dementia. The finding on pesticides is not supported in the overall literature. Am. J. Ind. Med. 58:625-635, 2015. (c) 2015 Wiley Periodicals, Inc.

AB - BackgroundOccupational exposures may be associated with non-vascular dementia.MethodsWe analyzed the effects of occupational exposures to solvents, pesticides, metals, extremely low frequency magnetic fields (ELF-MF), electrical shocks, and diesel motor exhaust on non-vascular dementia related mortality in the Netherlands Cohort Study (NLCS). Exposures were assigned using job-exposure matrices. After 17.3 years of follow-up, 682 male and 870 female cases were available. Analyses were performed using Cox regression.ResultsOccupational exposure to metals, chlorinated solvents and ELF-MF showed positive associations with non-vascular dementia among men, which seemed driven by metals (hazard ratio ever high vs. background exposure: 1.35 [0.98-1.86]). Pesticide exposure showed statistically significant, inverse associations with non-vascular dementia among men. We found no associations for shocks, aromatic solvents, and diesel motor exhaust.ConclusionsConsistent positive associations were found between occupational exposure to metals and non-vascular dementia. The finding on pesticides is not supported in the overall literature. Am. J. Ind. Med. 58:625-635, 2015. (c) 2015 Wiley Periodicals, Inc.

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