@article{22bb2363dee2431cba2aace486f3fe93,
title = "Obsessive-compulsive symptoms in psychotic disorders: longitudinal associations of symptom clusters on between- and within-subject levels",
abstract = "Obsessive-compulsive symptoms (OCS) are frequently reported in patients with schizophrenia and have been associated with subjective distress and higher impairment. Recent studies suggest fluctuation in co-occurring OCS and associations with the course of psychotic symptoms. Current evidence is limited by few studies with long assessments intervals and a sole focus on between-subject comparisons. The aim of this study was to specifically investigate co-variation of symptom domains over time within individuals. Patients with a psychotic disorder (n=56) and un-affected siblings (n=49) completed monthly assessments of clinical and subclinical symptoms over 6months. Mixed-model multilevel analyses examined the variability and relationship between OCS and positive, negative, and depressive symptoms on the between- and within-subject level. Symptom domains were associated across subjects and assessment times, in patients and siblings, with the strongest association between OCS and (subclinical) positive symptoms. Within-subjects, substantial variability and co-variation of all symptom domains was found. Particularly, between-subject differences in positive symptoms and within-subject change in depressive symptoms predicted subsequent OCS in patients 1months later. This is the first prospective study disaggregating between and within-subject associations between co-occurring OCS and symptom cluster of psychosis. Differences on these two levels suggest different underlying mechanisms. The association between depressive symptoms and subsequent increase/decrease of OCS within patients may have important treatment implications.",
keywords = "Psychosis, Obsessive-compulsive, Comorbidity, Longitudinal, Within-subject, PSYCHOMETRIC PROPERTIES, BETWEEN-PERSON, SCHIZOPHRENIA, METAANALYSIS, PREVALENCE, EXPERIENCE, MULTILEVEL, INVENTORY, VALIDITY, SPECTRUM",
author = "F. Schirmbeck and Max Konijn and Vera Hoetjes and Mathias Zink and {de Haan}, Lieuwe and Alizadeh, {B. Z.} and Bartels-Velthuis, {A. A.} and R. Bruggeman and {van Beveren}, {N. J.} and W. Cahn and Kahn, {R. S.} and {van Haren}, {N. E.} and {de Haan}, L. and Meijer, {C. J.} and Simons, {C. J. P.} and {van Os}, J. and P. Delespaul and I. Myin-Germeys and {van Winkel}, R. and {Genetic Risk and Outcome of Psychosis (GROUP) Investigators}",
note = "Funding Information: Acknowledgements We would like to thank the patients and siblings who took part in this study. F. S. was supported by a postdoc fellowship of the German Academic Exchange Service (DAAD). The GROUP-project is supported by a grant from the Geestkracht program of the Dutch Health Research Council (ZonMw, Grant No. 10-000-1002). GROUP investigators: B. Z. Alizadeh, A. A. Bartels-Velthuis, R. Bruggeman (University of Groningen, University Medical Center & Center for Psychiatry, Groningen, The Netherlands), N. J. van Bev-eren (Antes Center for Mental Health Care, Erasmus MC, Department of Psychiatry & Department of Neuroscience Rotterdam, The Netherlands), W. Cahn, R. S. Kahn, N. E. van Haren (University Medical Center, Department of Psychiatry, Brain Centre Rudolf Magnus, Utrecht, The Netherlands), L. de Haan, C. J. Meijer, F. Schirmbeck (Academic Medical Center, University of Amsterdam, Department of Psychiatry, Amsterdam, The Netherlands), C. J. P. Simons, J. van Os, P. Delespaul (Maastricht University Medical Center, Department of Psychiatry and Psychology, School for Mental Health and Neuroscience, Maastricht, The Netherlands), I. Myin-Germeys, R. van Winkel (KU Leuven, Department of Neuroscience, Center for Contextual Psychiatry, Leuven, Belgium). Funding Information: We would like to thank the patients and siblings who took part in this study. F. S. was supported by a postdoc fellowship of the German Academic Exchange Service (DAAD). The GROUP-project is supported by a grant from the Geestkracht program of the Dutch Health Research Council (ZonMw, Grant No. 10-000-1002). GROUP investigators: B. Z. Alizadeh, A. A. Bartels-Velthuis, R. Bruggeman (University of Groningen, University Medical Center & Center for Psychiatry, Groningen, The Netherlands), N. J. van Beveren (Antes Center for Mental Health Care, Erasmus MC, Department of Psychiatry & Department of Neuroscience Rotterdam, The Netherlands), W. Cahn, R. S. Kahn, N. E. van Haren (University Medical Center, Department of Psychiatry, Brain Centre Rudolf Magnus, Utrecht, The Netherlands), L. de Haan, C. J. Meijer, F. Schirmbeck (Academic Medical Center, University of Amsterdam, Department of Psychiatry, Amsterdam, The Netherlands), C. J. P. Simons, J. van Os, P. Delespaul (Maastricht University Medical Center, Department of Psychiatry and Psychology, School for Mental Health and Neuroscience, Maastricht, The Netherlands), I. Myin-Germeys, R. van Winkel (KU Leuven, Department of Neuroscience, Center for Contextual Psychiatry, Leuven, Belgium). Publisher Copyright: {\textcopyright} 2018, The Author(s).",
year = "2019",
month = mar,
doi = "10.1007/s00406-018-0884-4",
language = "English",
volume = "269",
pages = "245--255",
journal = "European Archives of Psychiatry and Clinical Neuroscience",
issn = "0940-1334",
publisher = "Springer",
number = "2",
}