TY - JOUR
T1 - N-SIPPV versus bi-level N-CPAP for early treatment of respiratory distress syndrome in preterm infants
AU - Ricotti, Alberto
AU - Salvo, Vincenzo
AU - Zimmermann, Luc J. I.
AU - Gavilanes, Antonio W. D.
AU - Barberi, Ignazio
AU - Lista, Gianluca
AU - Colivicchi, Micaela
AU - Temporini, Francesca
AU - Gazzolo, Diego
PY - 2013/9
Y1 - 2013/9
N2 - Objective: Non-invasive ventilation (NIV) for RDS in extremely/very low birth-weight infants represents the new challenge for neonatologists. In this regard, data comparing the effectiveness of Bi-Level-NCPAP (BiPAP) versus nasal synchronized intermittent positive pressure ventilation (NSIPPV) as primary mode of treatment for RDS are lacking. Study design: We conducted a retrospective study from December 2007 to December 2010 in seventy-eight infants, who received NIV (N-SIPPV: 33; BiPAP: 45). The primary outcomes were the length and failure of NIV. Secondary outcomes were adverse short-long term pulmonary outcomes, multiple doses of surfactant and others. Results: There were no significant differences (p>0.05) between the two different NIV modes. Conclusion: The present findings suggest that N-SIPPV and BiPAP gives similar results in the RDS treatment. We did not find a benefit of one over the other ventilation mode and both could be constitute a valid option to conventional mechanical ventilation. The theoretical benefits of these two different methods of NIV are tidal volume enhancement, improvements of the functional residual capacity and of the mean airway pressure and reducing apnea episodes. Further randomized studies to assess the advantages and the efficacy of different methods of NIV for the treatment of the RDS are needed.
AB - Objective: Non-invasive ventilation (NIV) for RDS in extremely/very low birth-weight infants represents the new challenge for neonatologists. In this regard, data comparing the effectiveness of Bi-Level-NCPAP (BiPAP) versus nasal synchronized intermittent positive pressure ventilation (NSIPPV) as primary mode of treatment for RDS are lacking. Study design: We conducted a retrospective study from December 2007 to December 2010 in seventy-eight infants, who received NIV (N-SIPPV: 33; BiPAP: 45). The primary outcomes were the length and failure of NIV. Secondary outcomes were adverse short-long term pulmonary outcomes, multiple doses of surfactant and others. Results: There were no significant differences (p>0.05) between the two different NIV modes. Conclusion: The present findings suggest that N-SIPPV and BiPAP gives similar results in the RDS treatment. We did not find a benefit of one over the other ventilation mode and both could be constitute a valid option to conventional mechanical ventilation. The theoretical benefits of these two different methods of NIV are tidal volume enhancement, improvements of the functional residual capacity and of the mean airway pressure and reducing apnea episodes. Further randomized studies to assess the advantages and the efficacy of different methods of NIV for the treatment of the RDS are needed.
KW - Bi-level CPAP
KW - nasal synchronized intermittent positive pressure ventilation
KW - non-invasive ventilation
KW - RDS
KW - very low birth-weight
U2 - 10.3109/14767058.2013.784255
DO - 10.3109/14767058.2013.784255
M3 - Article
C2 - 23488612
SN - 1476-7058
VL - 26
SP - 1346
EP - 1351
JO - Journal of Maternal-Fetal & Neonatal Medicine
JF - Journal of Maternal-Fetal & Neonatal Medicine
IS - 13
ER -