No association of the variant rs11887120 in DNMT3A with cognitive decline in individuals with mild cognitive impairment

Katharina Bey; Steffen Wolfsgruber; Ilker Karaca; Holger Wagner; Roy Lardenoije; Julian Becker; Esther Milz; Johannes Kornhuber; Oliver Peters; Lutz Froelich; Michael Huell; Eckart Ruether; Jens Wiltfang; Steffi Riedel-Heller; Martin Scherer; Frank Jessen; Wolfgang Maier; Daniel L. van den Hove; Bart P. F. Rutten; Michael Wagner; Alfredo Ramirez

doi:10.2217/epi-2015-0014

No association of the variant rs11887120 in DNMT3A with cognitive decline in individuals with mild cognitive impairment

Katharina Bey, Steffen Wolfsgruber, Ilker Karaca, Holger Wagner, Roy Lardenoije, Julian Becker, Esther Milz, Johannes Kornhuber, Oliver Peters, Lutz Froelich, Michael Huell, Eckart Ruether, Jens Wiltfang, Steffi Riedel-Heller, Martin Scherer, Frank Jessen, Wolfgang Maier, Daniel L. van den Hove, Bart P. F. Rutten, Michael WagnerAlfredo Ramirez^*

^*Corresponding author for this work

MHeNs - Neuroscience

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Alterations in DNA methylation have been associated with cognitive decline and Alzheimer's disease. A recent study of mild cognitive impairment (MCI) reported a significant association between annual decline in cognitive function and the rs11887120 SNP located in DNMT3A, a gene implicated in DNA methylation. Here, we aimed to replicate this finding in two independent MCI cohorts (n = 1024); however, no significant association was observed in either cohort or the pooled dataset. In stratified analyses for conversion to Alzheimer's disease status, no association between rs11887120 and cognitive decline was observed in either converters or nonconverters. In conclusion, our analyses provide no support for the hypothesis that genetic variants in DNMT3A are implicated in cognitive performance decline in individuals with MCI.

Original language	English
Pages (from-to)	593-598
Journal	Epigenomics
Volume	8
Issue number	5
DOIs	https://doi.org/10.2217/epi-2015-0014
Publication status	Published - May 2016

Keywords

aging
Alzheimer's disease
cognitive decline
DNA methylation
DNA methyltransferase 3a
DNMT3A
epigenetics
MCI
mild cognitive impairment
rs11887120

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10.2217/epi-2015-0014

Cite this

Bey, K., Wolfsgruber, S., Karaca, I., Wagner, H., Lardenoije, R., Becker, J., Milz, E., Kornhuber, J., Peters, O., Froelich, L., Huell, M., Ruether, E., Wiltfang, J., Riedel-Heller, S., Scherer, M., Jessen, F., Maier, W., van den Hove, D. L., Rutten, B. P. F., ... Ramirez, A. (2016). No association of the variant rs11887120 in DNMT3A with cognitive decline in individuals with mild cognitive impairment. Epigenomics, 8(5), 593-598. https://doi.org/10.2217/epi-2015-0014

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title = "No association of the variant rs11887120 in DNMT3A with cognitive decline in individuals with mild cognitive impairment",

abstract = "Alterations in DNA methylation have been associated with cognitive decline and Alzheimer's disease. A recent study of mild cognitive impairment (MCI) reported a significant association between annual decline in cognitive function and the rs11887120 SNP located in DNMT3A, a gene implicated in DNA methylation. Here, we aimed to replicate this finding in two independent MCI cohorts (n = 1024); however, no significant association was observed in either cohort or the pooled dataset. In stratified analyses for conversion to Alzheimer's disease status, no association between rs11887120 and cognitive decline was observed in either converters or nonconverters. In conclusion, our analyses provide no support for the hypothesis that genetic variants in DNMT3A are implicated in cognitive performance decline in individuals with MCI.",

keywords = "aging, Alzheimer's disease, cognitive decline, DNA methylation, DNA methyltransferase 3a, DNMT3A, epigenetics, MCI, mild cognitive impairment, rs11887120",

author = "Katharina Bey and Steffen Wolfsgruber and Ilker Karaca and Holger Wagner and Roy Lardenoije and Julian Becker and Esther Milz and Johannes Kornhuber and Oliver Peters and Lutz Froelich and Michael Huell and Eckart Ruether and Jens Wiltfang and Steffi Riedel-Heller and Martin Scherer and Frank Jessen and Wolfgang Maier and {van den Hove}, {Daniel L.} and Rutten, {Bart P. F.} and Michael Wagner and Alfredo Ramirez",

year = "2016",

month = may,

doi = "10.2217/epi-2015-0014",

language = "English",

volume = "8",

pages = "593--598",

journal = "Epigenomics",

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Bey, K, Wolfsgruber, S, Karaca, I, Wagner, H, Lardenoije, R, Becker, J, Milz, E, Kornhuber, J, Peters, O, Froelich, L, Huell, M, Ruether, E, Wiltfang, J, Riedel-Heller, S, Scherer, M, Jessen, F, Maier, W, van den Hove, DL , Rutten, BPF, Wagner, M & Ramirez, A 2016, 'No association of the variant rs11887120 in DNMT3A with cognitive decline in individuals with mild cognitive impairment', Epigenomics, vol. 8, no. 5, pp. 593-598. https://doi.org/10.2217/epi-2015-0014

TY - JOUR

T1 - No association of the variant rs11887120 in DNMT3A with cognitive decline in individuals with mild cognitive impairment

AU - Bey, Katharina

AU - Wolfsgruber, Steffen

AU - Karaca, Ilker

AU - Wagner, Holger

AU - Lardenoije, Roy

AU - Becker, Julian

AU - Milz, Esther

AU - Kornhuber, Johannes

AU - Peters, Oliver

AU - Froelich, Lutz

AU - Huell, Michael

AU - Ruether, Eckart

AU - Wiltfang, Jens

AU - Riedel-Heller, Steffi

AU - Scherer, Martin

AU - Jessen, Frank

AU - Maier, Wolfgang

AU - van den Hove, Daniel L.

AU - Rutten, Bart P. F.

AU - Wagner, Michael

AU - Ramirez, Alfredo

PY - 2016/5

Y1 - 2016/5

N2 - Alterations in DNA methylation have been associated with cognitive decline and Alzheimer's disease. A recent study of mild cognitive impairment (MCI) reported a significant association between annual decline in cognitive function and the rs11887120 SNP located in DNMT3A, a gene implicated in DNA methylation. Here, we aimed to replicate this finding in two independent MCI cohorts (n = 1024); however, no significant association was observed in either cohort or the pooled dataset. In stratified analyses for conversion to Alzheimer's disease status, no association between rs11887120 and cognitive decline was observed in either converters or nonconverters. In conclusion, our analyses provide no support for the hypothesis that genetic variants in DNMT3A are implicated in cognitive performance decline in individuals with MCI.

AB - Alterations in DNA methylation have been associated with cognitive decline and Alzheimer's disease. A recent study of mild cognitive impairment (MCI) reported a significant association between annual decline in cognitive function and the rs11887120 SNP located in DNMT3A, a gene implicated in DNA methylation. Here, we aimed to replicate this finding in two independent MCI cohorts (n = 1024); however, no significant association was observed in either cohort or the pooled dataset. In stratified analyses for conversion to Alzheimer's disease status, no association between rs11887120 and cognitive decline was observed in either converters or nonconverters. In conclusion, our analyses provide no support for the hypothesis that genetic variants in DNMT3A are implicated in cognitive performance decline in individuals with MCI.

KW - aging

KW - Alzheimer's disease

KW - cognitive decline

KW - DNA methylation

KW - DNA methyltransferase 3a

KW - DNMT3A

KW - epigenetics

KW - MCI

KW - mild cognitive impairment

KW - rs11887120

U2 - 10.2217/epi-2015-0014

DO - 10.2217/epi-2015-0014

M3 - Article

C2 - 27092400

SN - 1750-1911

VL - 8

SP - 593

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JO - Epigenomics

JF - Epigenomics

IS - 5

ER -