Research output

New membranes based on polyethersulfone - SlipSkin (TM) polymer blends with low fouling and high blood compatibility

Research output: Contribution to journalArticleAcademicpeer-review

Standard

New membranes based on polyethersulfone - SlipSkin (TM) polymer blends with low fouling and high blood compatibility. / ter Beek, O.; Pavlenko, D.; Suck, M.; Helfrich, S.; Bolhuis-Versteeg, L.; Snisarenko, D.; Causserand, C.; Bacchin, P.; Aimar, P.; van Oerle, R.; Wetzels, R.; Verhezen, P.; Henskens, Y.; Stamatialis, D.

In: Separation and Purification Technology, Vol. 225, 15.10.2019, p. 60-73.

Research output: Contribution to journalArticleAcademicpeer-review

Harvard

ter Beek, O, Pavlenko, D, Suck, M, Helfrich, S, Bolhuis-Versteeg, L, Snisarenko, D, Causserand, C, Bacchin, P, Aimar, P, van Oerle, R, Wetzels, R, Verhezen, P, Henskens, Y & Stamatialis, D 2019, 'New membranes based on polyethersulfone - SlipSkin (TM) polymer blends with low fouling and high blood compatibility', Separation and Purification Technology, vol. 225, pp. 60-73. https://doi.org/10.1016/j.seppur.2019.05.049

APA

ter Beek, O., Pavlenko, D., Suck, M., Helfrich, S., Bolhuis-Versteeg, L., Snisarenko, D., ... Stamatialis, D. (2019). New membranes based on polyethersulfone - SlipSkin (TM) polymer blends with low fouling and high blood compatibility. Separation and Purification Technology, 225, 60-73. https://doi.org/10.1016/j.seppur.2019.05.049

Vancouver

Author

ter Beek, O. ; Pavlenko, D. ; Suck, M. ; Helfrich, S. ; Bolhuis-Versteeg, L. ; Snisarenko, D. ; Causserand, C. ; Bacchin, P. ; Aimar, P. ; van Oerle, R. ; Wetzels, R. ; Verhezen, P. ; Henskens, Y. ; Stamatialis, D. / New membranes based on polyethersulfone - SlipSkin (TM) polymer blends with low fouling and high blood compatibility. In: Separation and Purification Technology. 2019 ; Vol. 225. pp. 60-73.

Bibtex

@article{740707113ac34962a7efc88cb53e0b0f,
title = "New membranes based on polyethersulfone - SlipSkin (TM) polymer blends with low fouling and high blood compatibility",
abstract = "Hemodialysis is an important therapy for treating patients with End Stage Renal Disease (ESRD). These patients visit the hospital 3 times a week and each time their blood is cleansed during 4-hour dialysis sessions using a hollow fiber membrane module; also called artificial kidney. This device mainly achieves removal of small water-soluble toxins and a limited number of middle molecules. To improve the clearance of toxins, especially middle molecules and protein bound toxins, longer treatment via nocturnal dialysis and/or the application of portable/wearable artificial kidney is required. Such therapies require application of membranes with very low fouling and very good blood compatibility. Current membranes often contain hydrophilic additives which could elute during sterilization processes and/or during long-term filtration. In this study, we propose a simple method for developing low fouling blood compatible membranes by blending of polyethersulfone (PES), a material already used for fabrication of dialysis membranes, with small amounts of SlipSkin (TM) (SS), a blood compatible random copolymer of hydrophilic N-vinylpyrrolidone (NVP) and hydrophobic N-butylmethacrylate (BMA). Our results show that membranes with 2 wt{\%} of SS have high fouling resistance to proteins and middle-size molecules and very good blood compatibility, making these membranes promising for application in dialysis therapy.",
keywords = "Hemodialysis, Membrane, Fouling, Biocompatibility, ULTRAFILTRATION MEMBRANES, UREMIC TOXINS, HEMOCOMPATIBILITY, STERILIZATION, PERFORMANCE, STABILITY, COPOLYMER, MODIFIER, DIALYSIS, REMOVAL",
author = "{ter Beek}, O. and D. Pavlenko and M. Suck and S. Helfrich and L. Bolhuis-Versteeg and D. Snisarenko and C. Causserand and P. Bacchin and P. Aimar and {van Oerle}, R. and R. Wetzels and P. Verhezen and Y. Henskens and D. Stamatialis",
year = "2019",
month = "10",
day = "15",
doi = "10.1016/j.seppur.2019.05.049",
language = "English",
volume = "225",
pages = "60--73",
journal = "Separation and Purification Technology",
issn = "1383-5866",
publisher = "Elsevier Science",

}

RIS

TY - JOUR

T1 - New membranes based on polyethersulfone - SlipSkin (TM) polymer blends with low fouling and high blood compatibility

AU - ter Beek, O.

AU - Pavlenko, D.

AU - Suck, M.

AU - Helfrich, S.

AU - Bolhuis-Versteeg, L.

AU - Snisarenko, D.

AU - Causserand, C.

AU - Bacchin, P.

AU - Aimar, P.

AU - van Oerle, R.

AU - Wetzels, R.

AU - Verhezen, P.

AU - Henskens, Y.

AU - Stamatialis, D.

PY - 2019/10/15

Y1 - 2019/10/15

N2 - Hemodialysis is an important therapy for treating patients with End Stage Renal Disease (ESRD). These patients visit the hospital 3 times a week and each time their blood is cleansed during 4-hour dialysis sessions using a hollow fiber membrane module; also called artificial kidney. This device mainly achieves removal of small water-soluble toxins and a limited number of middle molecules. To improve the clearance of toxins, especially middle molecules and protein bound toxins, longer treatment via nocturnal dialysis and/or the application of portable/wearable artificial kidney is required. Such therapies require application of membranes with very low fouling and very good blood compatibility. Current membranes often contain hydrophilic additives which could elute during sterilization processes and/or during long-term filtration. In this study, we propose a simple method for developing low fouling blood compatible membranes by blending of polyethersulfone (PES), a material already used for fabrication of dialysis membranes, with small amounts of SlipSkin (TM) (SS), a blood compatible random copolymer of hydrophilic N-vinylpyrrolidone (NVP) and hydrophobic N-butylmethacrylate (BMA). Our results show that membranes with 2 wt% of SS have high fouling resistance to proteins and middle-size molecules and very good blood compatibility, making these membranes promising for application in dialysis therapy.

AB - Hemodialysis is an important therapy for treating patients with End Stage Renal Disease (ESRD). These patients visit the hospital 3 times a week and each time their blood is cleansed during 4-hour dialysis sessions using a hollow fiber membrane module; also called artificial kidney. This device mainly achieves removal of small water-soluble toxins and a limited number of middle molecules. To improve the clearance of toxins, especially middle molecules and protein bound toxins, longer treatment via nocturnal dialysis and/or the application of portable/wearable artificial kidney is required. Such therapies require application of membranes with very low fouling and very good blood compatibility. Current membranes often contain hydrophilic additives which could elute during sterilization processes and/or during long-term filtration. In this study, we propose a simple method for developing low fouling blood compatible membranes by blending of polyethersulfone (PES), a material already used for fabrication of dialysis membranes, with small amounts of SlipSkin (TM) (SS), a blood compatible random copolymer of hydrophilic N-vinylpyrrolidone (NVP) and hydrophobic N-butylmethacrylate (BMA). Our results show that membranes with 2 wt% of SS have high fouling resistance to proteins and middle-size molecules and very good blood compatibility, making these membranes promising for application in dialysis therapy.

KW - Hemodialysis

KW - Membrane

KW - Fouling

KW - Biocompatibility

KW - ULTRAFILTRATION MEMBRANES

KW - UREMIC TOXINS

KW - HEMOCOMPATIBILITY

KW - STERILIZATION

KW - PERFORMANCE

KW - STABILITY

KW - COPOLYMER

KW - MODIFIER

KW - DIALYSIS

KW - REMOVAL

U2 - 10.1016/j.seppur.2019.05.049

DO - 10.1016/j.seppur.2019.05.049

M3 - Article

VL - 225

SP - 60

EP - 73

JO - Separation and Purification Technology

T2 - Separation and Purification Technology

JF - Separation and Purification Technology

SN - 1383-5866

ER -