N{epsilon}-(carboxymethyl)lysine during the early development of hypertension

M. Baumann; C.D.A. Stehouwer; J.L.J.M. Scheijen; U. Heemann; H.A.J. Struijker Boudier; C.G. Schalkwijk

doi:10.1196/annals.1433.004

N{epsilon}-(carboxymethyl)lysine during the early development of hypertension

M. Baumann^*, C.D.A. Stehouwer, J.L.J.M. Scheijen, U. Heemann, H.A.J. Struijker Boudier, C.G. Schalkwijk

^*Corresponding author for this work

CARIM School for Cardiovascular Diseases

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Advanced glycation end products (AGEs) are associated with hypertension. Whether N-epsilon-(carhoxymethyl)lysine (CML) contributes to the development of hypertension in young spontaneously hypertensive rats (SHR) remains to be established compared to W. We determined blood pressure, renal function, marker for oxidative stress (OS), and CML in young WKY rats and SHR. We found blood pressure was increased in SHR with no difference in renal function and OS compared to WKY. CML was elevated in plasma (2.3 +/- 0.3 vs. 1.3 +/- 0.2 mu mol/L) and kidney (1.0 +/- 0. 1 vs. 0.5 +/- 0.1 mu mol/L) compared to WKY. Early CML accumulation may contribute to the development of hypertension potentially by inducing early renal inflammation independent of glomerular dysfunction or oxidative stress.

Original language	English
Pages (from-to)	201-4
Journal	Annals of the New York Academy of Sciences
Volume	1126
DOIs	https://doi.org/10.1196/annals.1433.004
Publication status	Published - 1 Jan 2008

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10.1196/annals.1433.004

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title = "N{epsilon}-(carboxymethyl)lysine during the early development of hypertension",

abstract = "Advanced glycation end products (AGEs) are associated with hypertension. Whether N-epsilon-(carhoxymethyl)lysine (CML) contributes to the development of hypertension in young spontaneously hypertensive rats (SHR) remains to be established compared to W. We determined blood pressure, renal function, marker for oxidative stress (OS), and CML in young WKY rats and SHR. We found blood pressure was increased in SHR with no difference in renal function and OS compared to WKY. CML was elevated in plasma (2.3 +/- 0.3 vs. 1.3 +/- 0.2 mu mol/L) and kidney (1.0 +/- 0. 1 vs. 0.5 +/- 0.1 mu mol/L) compared to WKY. Early CML accumulation may contribute to the development of hypertension potentially by inducing early renal inflammation independent of glomerular dysfunction or oxidative stress.",

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T1 - N{epsilon}-(carboxymethyl)lysine during the early development of hypertension

AU - Baumann, M.

AU - Stehouwer, C.D.A.

AU - Scheijen, J.L.J.M.

AU - Heemann, U.

AU - Struijker Boudier, H.A.J.

AU - Schalkwijk, C.G.

PY - 2008/1/1

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N2 - Advanced glycation end products (AGEs) are associated with hypertension. Whether N-epsilon-(carhoxymethyl)lysine (CML) contributes to the development of hypertension in young spontaneously hypertensive rats (SHR) remains to be established compared to W. We determined blood pressure, renal function, marker for oxidative stress (OS), and CML in young WKY rats and SHR. We found blood pressure was increased in SHR with no difference in renal function and OS compared to WKY. CML was elevated in plasma (2.3 +/- 0.3 vs. 1.3 +/- 0.2 mu mol/L) and kidney (1.0 +/- 0. 1 vs. 0.5 +/- 0.1 mu mol/L) compared to WKY. Early CML accumulation may contribute to the development of hypertension potentially by inducing early renal inflammation independent of glomerular dysfunction or oxidative stress.

AB - Advanced glycation end products (AGEs) are associated with hypertension. Whether N-epsilon-(carhoxymethyl)lysine (CML) contributes to the development of hypertension in young spontaneously hypertensive rats (SHR) remains to be established compared to W. We determined blood pressure, renal function, marker for oxidative stress (OS), and CML in young WKY rats and SHR. We found blood pressure was increased in SHR with no difference in renal function and OS compared to WKY. CML was elevated in plasma (2.3 +/- 0.3 vs. 1.3 +/- 0.2 mu mol/L) and kidney (1.0 +/- 0. 1 vs. 0.5 +/- 0.1 mu mol/L) compared to WKY. Early CML accumulation may contribute to the development of hypertension potentially by inducing early renal inflammation independent of glomerular dysfunction or oxidative stress.

U2 - 10.1196/annals.1433.004

DO - 10.1196/annals.1433.004

M3 - Article

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JF - Annals of the New York Academy of Sciences

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