Negative mood-induction modulates default mode network resting-state functional connectivity in chronic depression

Fritz Renner; Nicolette Siep; Arnoud Arntz; Vincent van de Ven; Frenk P M L Peeters; Conny W E M Quaedflieg; Marcus J H Huibers

doi:10.1016/j.jad.2016.10.022

Negative mood-induction modulates default mode network resting-state functional connectivity in chronic depression

Fritz Renner^*, Nicolette Siep, Arnoud Arntz, Vincent van de Ven, Frenk P M L Peeters, Conny W E M Quaedflieg, Marcus J H Huibers

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

124 Downloads (Pure)

Abstract

BACKGROUND: The aim of this study was to investigate the effects of sad mood on default mode network (DMN) resting-state connectivity in persons with chronic major depressive disorder (cMDD).

METHODS: Participants with a diagnosis of cMDD (n=18) and age, gender and education level matched participants without a diagnosis of depression (n=18) underwent a resting-state fMRI scan, before and after a sad mood induction. The posterior cingulate cortex (PCC) was used as a seed for DMN functional connectivity across the two resting-state measurements.

RESULTS: Mood ratings decreased in both groups following the sad mood induction procedure. PCC connectivity with the parahippocampal gyrus, the superior temporal gyrus and the anterior inferior temporal cortex increased in cMDD patients following the sad mood induction, whereas it decreased in non-patient controls. PCC connectivity with the anterior prefrontal cortex and the precuneus decreased in cMDD patients following the sad mood induction, whereas it increased in non-patient controls.

LIMITATIONS: Limitations of this study include the relatively small sample size and lack of a clinical control group.

CONCLUSIONS: These findings are in line with neurobiological models of depression suggesting that the observed changes in DMN connectivity following the sad mood induction might reflect a failure to exert cognitive control over negative memory retrieval in patients with cMDD.

Original language	English
Pages (from-to)	590-596
Number of pages	7
Journal	Journal of Affective Disorders
Volume	208
DOIs	https://doi.org/10.1016/j.jad.2016.10.022
Publication status	Published - 15 Jan 2017

Access to Document

10.1016/j.jad.2016.10.022

Full TextFinal published version, 481 KBLicence: Taverne

Cite this

@article{6dfc9030654546b29c69123df1ed6e1a,

title = "Negative mood-induction modulates default mode network resting-state functional connectivity in chronic depression",

abstract = "BACKGROUND: The aim of this study was to investigate the effects of sad mood on default mode network (DMN) resting-state connectivity in persons with chronic major depressive disorder (cMDD).METHODS: Participants with a diagnosis of cMDD (n=18) and age, gender and education level matched participants without a diagnosis of depression (n=18) underwent a resting-state fMRI scan, before and after a sad mood induction. The posterior cingulate cortex (PCC) was used as a seed for DMN functional connectivity across the two resting-state measurements.RESULTS: Mood ratings decreased in both groups following the sad mood induction procedure. PCC connectivity with the parahippocampal gyrus, the superior temporal gyrus and the anterior inferior temporal cortex increased in cMDD patients following the sad mood induction, whereas it decreased in non-patient controls. PCC connectivity with the anterior prefrontal cortex and the precuneus decreased in cMDD patients following the sad mood induction, whereas it increased in non-patient controls.LIMITATIONS: Limitations of this study include the relatively small sample size and lack of a clinical control group.CONCLUSIONS: These findings are in line with neurobiological models of depression suggesting that the observed changes in DMN connectivity following the sad mood induction might reflect a failure to exert cognitive control over negative memory retrieval in patients with cMDD.",

author = "Fritz Renner and Nicolette Siep and Arnoud Arntz and {van de Ven}, Vincent and Peeters, {Frenk P M L} and Quaedflieg, {Conny W E M} and Huibers, {Marcus J H}",

year = "2017",

month = jan,

day = "15",

doi = "10.1016/j.jad.2016.10.022",

language = "English",

volume = "208",

pages = "590--596",

journal = "Journal of Affective Disorders",

issn = "0165-0327",

publisher = "Elsevier",

}

TY - JOUR

T1 - Negative mood-induction modulates default mode network resting-state functional connectivity in chronic depression

AU - Renner, Fritz

AU - Siep, Nicolette

AU - Arntz, Arnoud

AU - van de Ven, Vincent

AU - Peeters, Frenk P M L

AU - Quaedflieg, Conny W E M

AU - Huibers, Marcus J H

PY - 2017/1/15

Y1 - 2017/1/15

N2 - BACKGROUND: The aim of this study was to investigate the effects of sad mood on default mode network (DMN) resting-state connectivity in persons with chronic major depressive disorder (cMDD).METHODS: Participants with a diagnosis of cMDD (n=18) and age, gender and education level matched participants without a diagnosis of depression (n=18) underwent a resting-state fMRI scan, before and after a sad mood induction. The posterior cingulate cortex (PCC) was used as a seed for DMN functional connectivity across the two resting-state measurements.RESULTS: Mood ratings decreased in both groups following the sad mood induction procedure. PCC connectivity with the parahippocampal gyrus, the superior temporal gyrus and the anterior inferior temporal cortex increased in cMDD patients following the sad mood induction, whereas it decreased in non-patient controls. PCC connectivity with the anterior prefrontal cortex and the precuneus decreased in cMDD patients following the sad mood induction, whereas it increased in non-patient controls.LIMITATIONS: Limitations of this study include the relatively small sample size and lack of a clinical control group.CONCLUSIONS: These findings are in line with neurobiological models of depression suggesting that the observed changes in DMN connectivity following the sad mood induction might reflect a failure to exert cognitive control over negative memory retrieval in patients with cMDD.

AB - BACKGROUND: The aim of this study was to investigate the effects of sad mood on default mode network (DMN) resting-state connectivity in persons with chronic major depressive disorder (cMDD).METHODS: Participants with a diagnosis of cMDD (n=18) and age, gender and education level matched participants without a diagnosis of depression (n=18) underwent a resting-state fMRI scan, before and after a sad mood induction. The posterior cingulate cortex (PCC) was used as a seed for DMN functional connectivity across the two resting-state measurements.RESULTS: Mood ratings decreased in both groups following the sad mood induction procedure. PCC connectivity with the parahippocampal gyrus, the superior temporal gyrus and the anterior inferior temporal cortex increased in cMDD patients following the sad mood induction, whereas it decreased in non-patient controls. PCC connectivity with the anterior prefrontal cortex and the precuneus decreased in cMDD patients following the sad mood induction, whereas it increased in non-patient controls.LIMITATIONS: Limitations of this study include the relatively small sample size and lack of a clinical control group.CONCLUSIONS: These findings are in line with neurobiological models of depression suggesting that the observed changes in DMN connectivity following the sad mood induction might reflect a failure to exert cognitive control over negative memory retrieval in patients with cMDD.

U2 - 10.1016/j.jad.2016.10.022

DO - 10.1016/j.jad.2016.10.022

M3 - Article

C2 - 27810271

SN - 0165-0327

VL - 208

SP - 590

EP - 596

JO - Journal of Affective Disorders

JF - Journal of Affective Disorders

ER -