Multi-scale modeling and variability in cardiac cellular electrophysiology

Cardiac rhythm is the result of interactions between millions of heart muscle cells. Genetic, molecular and functional factors are involved on the cellular, tissue and organ level. Multi-scale computer models are used to study this complex interplay of processes on various levels. This dissertation introduces a software application that makes these models more versatile and easier to use. It also presents results on the effects of genetic mutations and natural variability on ion channel function in heart muscle cells. These results improve our understanding of the mechanisms of the heart and can serve as a catalyst for studies on cardiac arrhythmias.