Multi-level biomarker analysis of nitric oxide synthase isoforms in bipolar disorder and adult ADHD

Sarah Kittel-Schneider; Martin Reuss; Andrea Meyer; Heike Weber; Alexandra Gessner; Carolin Leistner; Juliane Kopf; Brigitte Schmidt; Susanne Hempel; Julia Volkert; Klaus-Peter Lesch; Andreas Reif

doi:10.1177/0269881114555251

Multi-level biomarker analysis of nitric oxide synthase isoforms in bipolar disorder and adult ADHD

Sarah Kittel-Schneider^*, Martin Reuss, Andrea Meyer, Heike Weber, Alexandra Gessner, Carolin Leistner, Juliane Kopf, Brigitte Schmidt, Susanne Hempel, Julia Volkert, Klaus-Peter Lesch, Andreas Reif

^*Corresponding author for this work

MHeNs - Neuroscience

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Several studies have shown altered levels of nitric oxide (NO) and its stable metabolites (NOx (-)) in blood and cerebrospinal fluid of psychiatric patients. The aim of our study was to replicate previous findings and investigate the influence of the nitrinergic system in bipolar disorder and adult attention-deficit/hyperactivity disorder (aADHD) in particular.The concentrations of NO2 (-) and NO3 (-) in peripheral blood in a sample of aADHD, bipolar disorder (BPD) and controls were analysed. The sample was genotyped for a three marker haplotype in the NOS3 gene (rs2070744, rs1799983 and Intron 4 VNTR) and for genetic variants of the NOS1 gene (NOS1 ex 1c, NOS1 ex 1f). Finally, qRT PCR was performed.We found significantly lower NOx (-) levels in BPD (p

Original language	English
Pages (from-to)	31-38
Journal	Journal of Psychopharmacology
Volume	29
Issue number	1
DOIs	https://doi.org/10.1177/0269881114555251
Publication status	Published - Jan 2015

Keywords

Nitric oxide
bipolar disorder
attention deficit-hyperactivity disorder
genetic polymorphism
biomarkers

Access to Document

10.1177/0269881114555251

Cite this

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title = "Multi-level biomarker analysis of nitric oxide synthase isoforms in bipolar disorder and adult ADHD",

abstract = "Several studies have shown altered levels of nitric oxide (NO) and its stable metabolites (NOx (-)) in blood and cerebrospinal fluid of psychiatric patients. The aim of our study was to replicate previous findings and investigate the influence of the nitrinergic system in bipolar disorder and adult attention-deficit/hyperactivity disorder (aADHD) in particular.The concentrations of NO2 (-) and NO3 (-) in peripheral blood in a sample of aADHD, bipolar disorder (BPD) and controls were analysed. The sample was genotyped for a three marker haplotype in the NOS3 gene (rs2070744, rs1799983 and Intron 4 VNTR) and for genetic variants of the NOS1 gene (NOS1 ex 1c, NOS1 ex 1f). Finally, qRT PCR was performed.We found significantly lower NOx (-) levels in BPD (p",

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author = "Sarah Kittel-Schneider and Martin Reuss and Andrea Meyer and Heike Weber and Alexandra Gessner and Carolin Leistner and Juliane Kopf and Brigitte Schmidt and Susanne Hempel and Julia Volkert and Klaus-Peter Lesch and Andreas Reif",

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T1 - Multi-level biomarker analysis of nitric oxide synthase isoforms in bipolar disorder and adult ADHD

AU - Kittel-Schneider, Sarah

AU - Reuss, Martin

AU - Meyer, Andrea

AU - Weber, Heike

AU - Gessner, Alexandra

AU - Leistner, Carolin

AU - Kopf, Juliane

AU - Schmidt, Brigitte

AU - Hempel, Susanne

AU - Volkert, Julia

AU - Lesch, Klaus-Peter

AU - Reif, Andreas

PY - 2015/1

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N2 - Several studies have shown altered levels of nitric oxide (NO) and its stable metabolites (NOx (-)) in blood and cerebrospinal fluid of psychiatric patients. The aim of our study was to replicate previous findings and investigate the influence of the nitrinergic system in bipolar disorder and adult attention-deficit/hyperactivity disorder (aADHD) in particular.The concentrations of NO2 (-) and NO3 (-) in peripheral blood in a sample of aADHD, bipolar disorder (BPD) and controls were analysed. The sample was genotyped for a three marker haplotype in the NOS3 gene (rs2070744, rs1799983 and Intron 4 VNTR) and for genetic variants of the NOS1 gene (NOS1 ex 1c, NOS1 ex 1f). Finally, qRT PCR was performed.We found significantly lower NOx (-) levels in BPD (p

AB - Several studies have shown altered levels of nitric oxide (NO) and its stable metabolites (NOx (-)) in blood and cerebrospinal fluid of psychiatric patients. The aim of our study was to replicate previous findings and investigate the influence of the nitrinergic system in bipolar disorder and adult attention-deficit/hyperactivity disorder (aADHD) in particular.The concentrations of NO2 (-) and NO3 (-) in peripheral blood in a sample of aADHD, bipolar disorder (BPD) and controls were analysed. The sample was genotyped for a three marker haplotype in the NOS3 gene (rs2070744, rs1799983 and Intron 4 VNTR) and for genetic variants of the NOS1 gene (NOS1 ex 1c, NOS1 ex 1f). Finally, qRT PCR was performed.We found significantly lower NOx (-) levels in BPD (p

KW - Nitric oxide

KW - bipolar disorder

KW - attention deficit-hyperactivity disorder

KW - genetic polymorphism

KW - biomarkers

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