Motor cortex stimulation does not lead to functional recovery after experimental cortical injury in rats

Lisa-Maria Schonfeld; Ali Jahanshahi; Evi Lemmens; Matthias Bauwens; Sarah-Anna Hescham; Sandra Schipper; Melanie Lagiere; Sven Hendrix; Yasin Temel

doi:10.3233/RNN-160703

Motor cortex stimulation does not lead to functional recovery after experimental cortical injury in rats

Lisa-Maria Schonfeld, Ali Jahanshahi^*, Evi Lemmens, Matthias Bauwens, Sarah-Anna Hescham, Sandra Schipper, Melanie Lagiere, Sven Hendrix^*, Yasin Temel

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Background: Motor impairments are among the major complications that develop after cortical damage caused by either stroke or traumatic brain injury. Motor cortex stimulation (MCS) can improve motor functions in animal models of stroke by inducing neuroplasticity.

Objective: In the current study, the therapeutic effect of chronic MCS was assessed in a rat model of severe cortical damage.

Methods: A controlled cortical impact (CCI) was applied to the forelimb area of the motor cortex followed by implantation of a flat electrode covering the lesioned area. Forelimb function was assessed using the Montoya staircase test and the cylinder test before and after a period of chronic MCS. Furthermore, the effect of MCS on tissue metabolism and lesion size was measured using [F-18]-fluorodesoxyglucose (FDG) mu PET scanning.

Results: CCI caused a considerable lesion at the level of the motor cortex and dorsal striatum together with a long-lasting behavioral phenotype of forelimb impairment. However, MCS applied to the CCI lesion did not lead to any improvement in limb functioning when compared to non-stimulated control rats. Also, MCS neither changed lesion size nor distribution of FDG.

Conclusion: The use of MCS as a standalone treatment did not improve motor impairments in a rat model of severe cortical damage using our specific treatment modalities.

Original language	English
Pages (from-to)	295-305
Number of pages	11
Journal	Restorative Neurology and Neuroscience
Volume	35
Issue number	3
DOIs	https://doi.org/10.3233/RNN-160703
Publication status	Published - 2017

Keywords

Motor cortex stimulation
motor impairment
rehabilitation
behavioral tests
PET
TRAUMATIC BRAIN-INJURY
FOCAL CEREBRAL-ISCHEMIA
ELECTRICAL-STIMULATION
STROKE
MULTICENTER
MIGRATION
INFARCT
FEASIBILITY
PLASTICITY
PROMOTES

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10.3233/RNN-160703

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Cite this

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title = "Motor cortex stimulation does not lead to functional recovery after experimental cortical injury in rats",

abstract = "Background: Motor impairments are among the major complications that develop after cortical damage caused by either stroke or traumatic brain injury. Motor cortex stimulation (MCS) can improve motor functions in animal models of stroke by inducing neuroplasticity.Objective: In the current study, the therapeutic effect of chronic MCS was assessed in a rat model of severe cortical damage.Methods: A controlled cortical impact (CCI) was applied to the forelimb area of the motor cortex followed by implantation of a flat electrode covering the lesioned area. Forelimb function was assessed using the Montoya staircase test and the cylinder test before and after a period of chronic MCS. Furthermore, the effect of MCS on tissue metabolism and lesion size was measured using [F-18]-fluorodesoxyglucose (FDG) mu PET scanning.Results: CCI caused a considerable lesion at the level of the motor cortex and dorsal striatum together with a long-lasting behavioral phenotype of forelimb impairment. However, MCS applied to the CCI lesion did not lead to any improvement in limb functioning when compared to non-stimulated control rats. Also, MCS neither changed lesion size nor distribution of FDG.Conclusion: The use of MCS as a standalone treatment did not improve motor impairments in a rat model of severe cortical damage using our specific treatment modalities.",

keywords = "Motor cortex stimulation, motor impairment, rehabilitation, behavioral tests, PET, TRAUMATIC BRAIN-INJURY, FOCAL CEREBRAL-ISCHEMIA, ELECTRICAL-STIMULATION, STROKE, MULTICENTER, MIGRATION, INFARCT, FEASIBILITY, PLASTICITY, PROMOTES",

author = "Lisa-Maria Schonfeld and Ali Jahanshahi and Evi Lemmens and Matthias Bauwens and Sarah-Anna Hescham and Sandra Schipper and Melanie Lagiere and Sven Hendrix and Yasin Temel",

year = "2017",

doi = "10.3233/RNN-160703",

language = "English",

volume = "35",

pages = "295--305",

journal = "Restorative Neurology and Neuroscience",

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publisher = "IOS Press",

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}

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T1 - Motor cortex stimulation does not lead to functional recovery after experimental cortical injury in rats

AU - Schonfeld, Lisa-Maria

AU - Jahanshahi, Ali

AU - Lemmens, Evi

AU - Bauwens, Matthias

AU - Hescham, Sarah-Anna

AU - Schipper, Sandra

AU - Lagiere, Melanie

AU - Hendrix, Sven

AU - Temel, Yasin

PY - 2017

Y1 - 2017

N2 - Background: Motor impairments are among the major complications that develop after cortical damage caused by either stroke or traumatic brain injury. Motor cortex stimulation (MCS) can improve motor functions in animal models of stroke by inducing neuroplasticity.Objective: In the current study, the therapeutic effect of chronic MCS was assessed in a rat model of severe cortical damage.Methods: A controlled cortical impact (CCI) was applied to the forelimb area of the motor cortex followed by implantation of a flat electrode covering the lesioned area. Forelimb function was assessed using the Montoya staircase test and the cylinder test before and after a period of chronic MCS. Furthermore, the effect of MCS on tissue metabolism and lesion size was measured using [F-18]-fluorodesoxyglucose (FDG) mu PET scanning.Results: CCI caused a considerable lesion at the level of the motor cortex and dorsal striatum together with a long-lasting behavioral phenotype of forelimb impairment. However, MCS applied to the CCI lesion did not lead to any improvement in limb functioning when compared to non-stimulated control rats. Also, MCS neither changed lesion size nor distribution of FDG.Conclusion: The use of MCS as a standalone treatment did not improve motor impairments in a rat model of severe cortical damage using our specific treatment modalities.

AB - Background: Motor impairments are among the major complications that develop after cortical damage caused by either stroke or traumatic brain injury. Motor cortex stimulation (MCS) can improve motor functions in animal models of stroke by inducing neuroplasticity.Objective: In the current study, the therapeutic effect of chronic MCS was assessed in a rat model of severe cortical damage.Methods: A controlled cortical impact (CCI) was applied to the forelimb area of the motor cortex followed by implantation of a flat electrode covering the lesioned area. Forelimb function was assessed using the Montoya staircase test and the cylinder test before and after a period of chronic MCS. Furthermore, the effect of MCS on tissue metabolism and lesion size was measured using [F-18]-fluorodesoxyglucose (FDG) mu PET scanning.Results: CCI caused a considerable lesion at the level of the motor cortex and dorsal striatum together with a long-lasting behavioral phenotype of forelimb impairment. However, MCS applied to the CCI lesion did not lead to any improvement in limb functioning when compared to non-stimulated control rats. Also, MCS neither changed lesion size nor distribution of FDG.Conclusion: The use of MCS as a standalone treatment did not improve motor impairments in a rat model of severe cortical damage using our specific treatment modalities.

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KW - TRAUMATIC BRAIN-INJURY

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KW - ELECTRICAL-STIMULATION

KW - STROKE

KW - MULTICENTER

KW - MIGRATION

KW - INFARCT

KW - FEASIBILITY

KW - PLASTICITY

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JO - Restorative Neurology and Neuroscience

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