Miniaturization: The Clue to Clinical Application of the Artificial Placenta

Mark Schoberer; Jutta Arens; Aileen Erben; Daan Ophelders; Reint K. Jellema; Boris W. Kramer; Jan L. Bruse; Petra de Brouwer; Thomas Schmitz-Rode; Ulrich Steinseifer; Thorsten Orlikowsky

doi:10.1111/aor.12146

Miniaturization: The Clue to Clinical Application of the Artificial Placenta

Mark Schoberer^*, Jutta Arens, Aileen Erben, Daan Ophelders, Reint K. Jellema, Boris W. Kramer, Jan L. Bruse, Petra de Brouwer, Thomas Schmitz-Rode, Ulrich Steinseifer, Thorsten Orlikowsky

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The artificial placenta as a fascinating treatment alternative for neonatal lung failure has been the subject of clinical research for over 50 years. Pumpless systems have been in use since 1986. However, inappropriate dimensioning of commercially available oxygenators has wasted some of the theoretical advantages of this concept. Disproportional shunt fractions can cause congestive heart failure. Blood priming of large oxygenators and circuits dilutes fetal hemoglobin (as the superior oxygen carrier), is potentially infectious, and causes inflammatory reactions. Flow demands of large extracorporeal circuits require cannula sizes that are not appropriate for use in preterm infants. NeonatOx, a tailored low-volume oxygenator for this purpose, has proven the feasibility of this principle before. We now report the advances in biological performance of a refined version of this specialized oxygenator.

Original language	English
Pages (from-to)	208-214
Journal	Artificial Organs
Volume	38
Issue number	3
DOIs	https://doi.org/10.1111/aor.12146
Publication status	Published - Mar 2014

Keywords

Artificial placenta
Extracorporeal life support
Interventional lung assist
Neonatal respiratory failure

Access to Document

10.1111/aor.12146

Cite this

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title = "Miniaturization: The Clue to Clinical Application of the Artificial Placenta",

abstract = "The artificial placenta as a fascinating treatment alternative for neonatal lung failure has been the subject of clinical research for over 50 years. Pumpless systems have been in use since 1986. However, inappropriate dimensioning of commercially available oxygenators has wasted some of the theoretical advantages of this concept. Disproportional shunt fractions can cause congestive heart failure. Blood priming of large oxygenators and circuits dilutes fetal hemoglobin (as the superior oxygen carrier), is potentially infectious, and causes inflammatory reactions. Flow demands of large extracorporeal circuits require cannula sizes that are not appropriate for use in preterm infants. NeonatOx, a tailored low-volume oxygenator for this purpose, has proven the feasibility of this principle before. We now report the advances in biological performance of a refined version of this specialized oxygenator.",

keywords = "Artificial placenta, Extracorporeal life support, Interventional lung assist, Neonatal respiratory failure",

author = "Mark Schoberer and Jutta Arens and Aileen Erben and Daan Ophelders and Jellema, {Reint K.} and Kramer, {Boris W.} and Bruse, {Jan L.} and {de Brouwer}, Petra and Thomas Schmitz-Rode and Ulrich Steinseifer and Thorsten Orlikowsky",

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T1 - Miniaturization: The Clue to Clinical Application of the Artificial Placenta

AU - Schoberer, Mark

AU - Arens, Jutta

AU - Erben, Aileen

AU - Ophelders, Daan

AU - Jellema, Reint K.

AU - Kramer, Boris W.

AU - Bruse, Jan L.

AU - de Brouwer, Petra

AU - Schmitz-Rode, Thomas

AU - Steinseifer, Ulrich

AU - Orlikowsky, Thorsten

PY - 2014/3

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AB - The artificial placenta as a fascinating treatment alternative for neonatal lung failure has been the subject of clinical research for over 50 years. Pumpless systems have been in use since 1986. However, inappropriate dimensioning of commercially available oxygenators has wasted some of the theoretical advantages of this concept. Disproportional shunt fractions can cause congestive heart failure. Blood priming of large oxygenators and circuits dilutes fetal hemoglobin (as the superior oxygen carrier), is potentially infectious, and causes inflammatory reactions. Flow demands of large extracorporeal circuits require cannula sizes that are not appropriate for use in preterm infants. NeonatOx, a tailored low-volume oxygenator for this purpose, has proven the feasibility of this principle before. We now report the advances in biological performance of a refined version of this specialized oxygenator.

KW - Artificial placenta

KW - Extracorporeal life support

KW - Interventional lung assist

KW - Neonatal respiratory failure

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DO - 10.1111/aor.12146

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