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Mindfulness-based cognitive therapy severely fatigued multiple sclerosis patients: A waiting list controlled study

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BACKGROUND: Fatigue is the most common symptom in multiple sclerosis. Evidence-based treatment options are scarce.

OBJECTIVE: To study the feasibility and potential effectiveness of mindfulness-based cognitive therapy in severely fatigued multiple sclerosis patients.

METHODS: Non-randomized pilot study with a wai-ting list control period including 59 multiple sclerosis patients with severe fatigue.

PRIMARY OUTCOME MEASURE: fatigue severity subscale of the Checklist Individual Strength-20. Secondary measures: Hospital Anxiety and Depression Scale, Life Satisfaction Questionnaire, subscale sleep of the Symptom Checklist-90, Cognitive Failure Questionnaire, Fatigue Catastrophizing Scale, Coping Inventory of Stressful Situations, and Five Facet Mindfulness Questionnaire-Short Form. Measurements were taken before treatment (double baseline), after treatment, and at follow-up (3 months).

RESULTS: Adherence rate was 71%. Eight out of 10 participants who completed the intervention were satisfied with the intervention. Significant time effects were found for 7 out of 11 outcome measures (p = 0.006 to < 0.001). The effect size was moderate for all outcome measures that were significant post-treatment and/or at follow-up (Ƞ² = 0.10-0.17). Improvements were maintained at follow-up. Of the completers, 46% showed a clinically relevant change regarding fatigue.

CONCLUSION: Mindfulness-based cognitive therapy is feasible in severely fatigued multiple sclerosis patients and has positive results in the reduction of severe fatigue and several psychological factors.

    Research areas

  • Journal Article, DEPRESSION SCALE, BEHAVIOR THERAPY, multiple sclerosis, mindfulness, MS, VALIDATION, HOSPITAL ANXIETY, mindfulness-based cognitive therapy, RANDOMIZED CONTROLLED-TRIAL, CANCER, IMPAIRMENT, fatigue, QUALITY-OF-LIFE
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Original languageEnglish
Pages (from-to)497–504
Number of pages8
JournalJournal of Rehabilitation Medicine
Issue number6
Publication statusPublished - 8 Jun 2017