Research output

Microvascular and blood-brain barrier dysfunction in Alzheimer’s disease: New insights from quantitative magnetic resonance imaging

Research output: ThesisDoctoral ThesisInternal

Associated researcher

  • van de Haar, H. J.

Associated organisations


Cerebral microvascular abnormalities play a key role in people with Alzheimer’s disease. The condition of these small blood vessels can be assessed by means of an MRI scan with contrast. It is shown that there is a minor but measurable contrast leakage from the blood circulation into the brain. The so-called blood-brain barrier should ensure that the contrast agent remains within the blood circulation. The leakage observed is a sign, therefore, that this barrier is damaged in Alzheimer’s disease – even in people who show no signs of vascular damage at first sight.

    Research areas

  • Alzheimer's disease, MRI scan, diagnosis, blood-brain barrier


  • Full text

    Final published version, 4 MB, PDF-document

  • Abstract

    Final published version, 137 KB, PDF-document

  • Propositions

    Final published version, 50 KB, PDF-document

  • Cover

    Final published version, 56 KB, image/jpeg

  • Valorisation

    Final published version, 71 KB, PDF-document

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Original languageEnglish
Awarding Institution
Award date10 Nov 2016
Place of PublicationMaastricht
  • Maastricht University
Publication statusPublished - 2016