TY - JOUR
T1 - Memory deficits in the transgenic rat model of Huntington's disease
AU - Zeef, Dagmar H.
AU - van Goethem, Nick P.
AU - Vlamings, Rinske
AU - Schaper, Frederic
AU - Jahanshahi, Ali
AU - Hescham, Sarah
AU - von Hoersten, Stephan
AU - Prickaerts, Jos
AU - Temel, Yasin
PY - 2012/2/1
Y1 - 2012/2/1
N2 - Memory deficits are common in patients with Huntington's disease (HD) and have a substantial impact on the quality of life of patients and their relatives. A good model resembling the human memory deficits is needed for research purposes. In this study we investigated the memory function of the transgenic rat model of Huntington's disease (tgHD) in the object location (OLT) and the object recognition task (ORT). Several studies have shown that the recent developed tgHD rat model resembles the human phenotype of HD. Impairments of spatial and object recognition memory in the OLT and ORT, however, have to our knowledge not yet been reported in this transgenic model. Our findings show that in both early and late stages of the disease the tgHD rats have clear deficits for both visuospatial and visual object memory. Since HD patients are known to be impaired in both types of memory, these results confirm the validity of this tgHD rat as a model for the human HD phenotype.
AB - Memory deficits are common in patients with Huntington's disease (HD) and have a substantial impact on the quality of life of patients and their relatives. A good model resembling the human memory deficits is needed for research purposes. In this study we investigated the memory function of the transgenic rat model of Huntington's disease (tgHD) in the object location (OLT) and the object recognition task (ORT). Several studies have shown that the recent developed tgHD rat model resembles the human phenotype of HD. Impairments of spatial and object recognition memory in the OLT and ORT, however, have to our knowledge not yet been reported in this transgenic model. Our findings show that in both early and late stages of the disease the tgHD rats have clear deficits for both visuospatial and visual object memory. Since HD patients are known to be impaired in both types of memory, these results confirm the validity of this tgHD rat as a model for the human HD phenotype.
KW - Huntington's disease
KW - Transgenic rat model
KW - Memory deficits
KW - Object recognition memory
KW - Object location memory
U2 - 10.1016/j.bbr.2011.11.009
DO - 10.1016/j.bbr.2011.11.009
M3 - Article
C2 - 22101303
SN - 0166-4328
VL - 227
SP - 194
EP - 198
JO - Behavioural Brain Research
JF - Behavioural Brain Research
IS - 1
ER -