TY - JOUR
T1 - Maternal diet during pregnancy and micronuclei frequency in peripheral blood T lymphocytes in mothers and newborns (Rhea cohort, Crete)
AU - O'Callaghan-Gordo, Cristina
AU - Kogevinas, Manolis
AU - Pedersen, Marie
AU - Fthenou, Eleni
AU - Espinosa, Ana
AU - Tsiapa, Xristina
AU - Chalkiadaki, Georgia
AU - Daraki, Vasiliki
AU - Dermitzaki, Eirini
AU - Decordier, Ilse
AU - Farmer, Peter B.
AU - Georgiadis, Panagiotis
AU - Georgiou, Vaggelis
AU - Kyrtopoulos, Soterios A.
AU - Merlo, Domenico Franco
AU - Romaguera, Dora
AU - Roumeliotaki, Theano
AU - Sarri, Katerina
AU - Tornqvist, Margareta
AU - Vande Loock, Kim
AU - von Stedingk, Hans
AU - Kleinjans, Jos
AU - Kirsch-Volders, Micheline
AU - Chatzi, Leda
PY - 2018/2/1
Y1 - 2018/2/1
N2 - Purpose The study assessed whether diet and adherence to cancer prevention guidelines during pregnancy were associated with micronucleus (MN) frequency in mothers and newborns. MN is biomarkers of early genetic effects that have been associated with cancer risk in adults. Methods A total of 188 mothers and 200 newborns from the Rhea cohort (Greece) were included in the study. At early-mid pregnancy, we conducted personal interviews and a validated food frequency questionnaire was completed. With this information, we constructed a score reflecting adherence to the World Cancer Research Fund/American Institute for Cancer Research cancer prevention guidelines on diet, physical activity and body fatness. At delivery, maternal and/or cord blood was collected to measure DNA and hemoglobin adducts of dietary origin and frequencies of MN in binucleated and mononucleated T lymphocytes (MNBN and MNMONO). Results In mothers, higher levels of red meat consumption were associated with increased MNBN frequency [2nd tertile IRR = 1.34 (1.00, 1.80), 3rd tertile IRR = 1.33 (0.96, 1.85)] and MNMONO frequency [2nd tertile IRR = 1.53 (0.84, 2.77), 3rd tertile IRR = 2.69 (1.44, 5.05)]. The opposite trend was observed for MNBN in newborns [2nd tertile IRR = 0.64 (0.44, 0.94), 3rd tertile IRR = 0.68 (0.46, 1.01)], and no association was observed with MNMONO. Increased MN frequency in pregnant women with high red meat consumption is consistent with previous knowledge. Conclusions Our results also suggest exposure to genotoxics during pregnancy might affect differently mothers and newborns. The predictive value of MN as biomarker for childhood cancer, rather than adulthood, remains unclear. With few exceptions, the association between maternal carcinogenic exposures during pregnancy and childhood cancer or early biologic effect biomarkers remains poorly understood.
AB - Purpose The study assessed whether diet and adherence to cancer prevention guidelines during pregnancy were associated with micronucleus (MN) frequency in mothers and newborns. MN is biomarkers of early genetic effects that have been associated with cancer risk in adults. Methods A total of 188 mothers and 200 newborns from the Rhea cohort (Greece) were included in the study. At early-mid pregnancy, we conducted personal interviews and a validated food frequency questionnaire was completed. With this information, we constructed a score reflecting adherence to the World Cancer Research Fund/American Institute for Cancer Research cancer prevention guidelines on diet, physical activity and body fatness. At delivery, maternal and/or cord blood was collected to measure DNA and hemoglobin adducts of dietary origin and frequencies of MN in binucleated and mononucleated T lymphocytes (MNBN and MNMONO). Results In mothers, higher levels of red meat consumption were associated with increased MNBN frequency [2nd tertile IRR = 1.34 (1.00, 1.80), 3rd tertile IRR = 1.33 (0.96, 1.85)] and MNMONO frequency [2nd tertile IRR = 1.53 (0.84, 2.77), 3rd tertile IRR = 2.69 (1.44, 5.05)]. The opposite trend was observed for MNBN in newborns [2nd tertile IRR = 0.64 (0.44, 0.94), 3rd tertile IRR = 0.68 (0.46, 1.01)], and no association was observed with MNMONO. Increased MN frequency in pregnant women with high red meat consumption is consistent with previous knowledge. Conclusions Our results also suggest exposure to genotoxics during pregnancy might affect differently mothers and newborns. The predictive value of MN as biomarker for childhood cancer, rather than adulthood, remains unclear. With few exceptions, the association between maternal carcinogenic exposures during pregnancy and childhood cancer or early biologic effect biomarkers remains poorly understood.
KW - Maternal nutrition
KW - Cancer
KW - Genotoxicity
KW - Diet
KW - Epidemiology
KW - POLYCYCLIC AROMATIC-HYDROCARBONS
KW - N-NITROSO COMPOUNDS
KW - COLORECTAL-CANCER
KW - DNA-ADDUCTS
KW - RISK
KW - NEWGENERIS
KW - EXPOSURE
KW - CARCINOGENICITY
KW - VALIDATION
KW - PREVENTION
U2 - 10.1007/s00394-016-1310-1
DO - 10.1007/s00394-016-1310-1
M3 - Article
C2 - 27655526
SN - 1436-6207
VL - 57
SP - 209
EP - 218
JO - European Journal of Nutrition
JF - European Journal of Nutrition
IS - 1
ER -