Malnutrition and Fracture Healing: Are Specific Deficiencies in Amino Acids Important in Nonunion Development?

Dennis M. Meesters; Karolina A. P. Wijnands; Peter R. G. Brink; Martijn Poeze

doi:10.3390/nu10111597

Malnutrition and Fracture Healing: Are Specific Deficiencies in Amino Acids Important in Nonunion Development?

Dennis M. Meesters^*, Karolina A. P. Wijnands, Peter R. G. Brink, Martijn Poeze

^*Corresponding author for this work

Research output: Contribution to journal › (Systematic) Review article › peer-review

Abstract

With the increasing incidence of fractures now, and in the future, the absolute number of bone-healing complications such as nonunion development will also increase. Next to fracture-dependent factors such as large bone loss volumes and inadequate stabilization, the nutritional state of these patients is a major influential factor for the fracture repair process. In this review, we will focus on the influence of protein/amino acid malnutrition and its influence on fracture healing. Mainly, the arginine-citrulline-nitric oxide metabolism is of importance since it can affect fracture healing via several precursors of collagen formation, and through nitric oxide synthases it has influences on the bio-molecular inflammatory responses and the local capillary growth and circulation.

Original language	English
Article number	1597
Number of pages	12
Journal	Nutrients
Volume	10
Issue number	11
DOIs	https://doi.org/10.3390/nu10111597
Publication status	Published - Nov 2018

Keywords

fracture healing
nonunion
arginine
citrulline
nitric oxide
nitric oxide synthase
NITRIC-OXIDE SYNTHASE
BONE MORPHOGENETIC PROTEINS
L-ARGININE
RISK-FACTORS
COLLAGEN-SYNTHESIS
ELDERLY-PATIENTS
EXPRESSION
GROWTH
CLASSIFICATION
EPIDEMIOLOGY

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Cite this

@article{27ef8b16925a40248c40679a088b6d30,

title = "Malnutrition and Fracture Healing: Are Specific Deficiencies in Amino Acids Important in Nonunion Development?",

abstract = "With the increasing incidence of fractures now, and in the future, the absolute number of bone-healing complications such as nonunion development will also increase. Next to fracture-dependent factors such as large bone loss volumes and inadequate stabilization, the nutritional state of these patients is a major influential factor for the fracture repair process. In this review, we will focus on the influence of protein/amino acid malnutrition and its influence on fracture healing. Mainly, the arginine-citrulline-nitric oxide metabolism is of importance since it can affect fracture healing via several precursors of collagen formation, and through nitric oxide synthases it has influences on the bio-molecular inflammatory responses and the local capillary growth and circulation.",

keywords = "fracture healing, nonunion, arginine, citrulline, nitric oxide, nitric oxide synthase, NITRIC-OXIDE SYNTHASE, BONE MORPHOGENETIC PROTEINS, L-ARGININE, RISK-FACTORS, COLLAGEN-SYNTHESIS, ELDERLY-PATIENTS, EXPRESSION, GROWTH, CLASSIFICATION, EPIDEMIOLOGY",

author = "Meesters, {Dennis M.} and Wijnands, {Karolina A. P.} and Brink, {Peter R. G.} and Martijn Poeze",

year = "2018",

month = nov,

doi = "10.3390/nu10111597",

language = "English",

volume = "10",

journal = "Nutrients",

issn = "2072-6643",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "11",

}

TY - JOUR

T1 - Malnutrition and Fracture Healing

T2 - Are Specific Deficiencies in Amino Acids Important in Nonunion Development?

AU - Meesters, Dennis M.

AU - Wijnands, Karolina A. P.

AU - Brink, Peter R. G.

AU - Poeze, Martijn

PY - 2018/11

Y1 - 2018/11

N2 - With the increasing incidence of fractures now, and in the future, the absolute number of bone-healing complications such as nonunion development will also increase. Next to fracture-dependent factors such as large bone loss volumes and inadequate stabilization, the nutritional state of these patients is a major influential factor for the fracture repair process. In this review, we will focus on the influence of protein/amino acid malnutrition and its influence on fracture healing. Mainly, the arginine-citrulline-nitric oxide metabolism is of importance since it can affect fracture healing via several precursors of collagen formation, and through nitric oxide synthases it has influences on the bio-molecular inflammatory responses and the local capillary growth and circulation.

AB - With the increasing incidence of fractures now, and in the future, the absolute number of bone-healing complications such as nonunion development will also increase. Next to fracture-dependent factors such as large bone loss volumes and inadequate stabilization, the nutritional state of these patients is a major influential factor for the fracture repair process. In this review, we will focus on the influence of protein/amino acid malnutrition and its influence on fracture healing. Mainly, the arginine-citrulline-nitric oxide metabolism is of importance since it can affect fracture healing via several precursors of collagen formation, and through nitric oxide synthases it has influences on the bio-molecular inflammatory responses and the local capillary growth and circulation.

KW - fracture healing

KW - nonunion

KW - arginine

KW - citrulline

KW - nitric oxide

KW - nitric oxide synthase

KW - NITRIC-OXIDE SYNTHASE

KW - BONE MORPHOGENETIC PROTEINS

KW - L-ARGININE

KW - RISK-FACTORS

KW - COLLAGEN-SYNTHESIS

KW - ELDERLY-PATIENTS

KW - EXPRESSION

KW - GROWTH

KW - CLASSIFICATION

KW - EPIDEMIOLOGY

U2 - 10.3390/nu10111597

DO - 10.3390/nu10111597

M3 - (Systematic) Review article

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SN - 2072-6643

VL - 10

JO - Nutrients

JF - Nutrients

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M1 - 1597

ER -