TY - JOUR
T1 - Male Sex Is Independently Associated with Faster Disability Accumulation in Relapse-Onset MS but Not in Primary Progressive MS
AU - Ribbons, Karen Ann
AU - McElduff, Patrick
AU - Boz, Cavit
AU - Trojano, Maria
AU - Izquierdo, Guillermo
AU - Duquette, Pierre
AU - Girard, Marc
AU - Grand'Maison, Francois
AU - Hupperts, Raymond
AU - Grammond, Pierre
AU - Oreja-Guevara, Celia
AU - Petersen, Thor
AU - Bergamaschi, Roberto
AU - Giuliani, Giorgio
AU - Barnett, Michael
AU - van Pesch, Vincent
AU - Amato, Maria-Pia
AU - Iuliano, Gerardo
AU - Fiol, Marcela
AU - Slee, Mark
AU - Verheul, Freek
AU - Cristiano, Edgardo
AU - Fernandez-Bolanos, Ricardo
AU - Saladino, Maria-Laura
AU - Rio, Maria Edite
AU - Cabrera-Gomez, Jose
AU - Butzkueven, Helmut
AU - van Munster, Erik
AU - Den Braber-Moerland, Leontien
AU - La Spitaleri, Daniele
AU - Lugaresi, Alessandra
AU - Shaygannejad, Vahid
AU - Gray, Orla
AU - Deri, Norma
AU - Alroughani, Raed
AU - Lechner-Scott, Jeannette
PY - 2015/6/5
Y1 - 2015/6/5
N2 - Multiple Sclerosis is more common in women than men and females have more relapses than men. In a large international cohort we have evaluated the effect of gender on disability accumulation and disease progression to determine if male MS patients have a worse clinical outcome than females.Using the MSBase Registry, data from 15,826 MS patients from 25 countries was analysed. Changes in the severity of MS (EDSS) were compared between sexes using a repeated measures analysis in generalised linear mixed models. Kaplan-Meier analysis was used to test for sex difference in the time to reach EDSS milestones 3 and 6 and the secondary progressive MS.In relapse onset MS patients (n = 14,453), males progressed significantly faster in their EDSS than females (0.133 vs 0.112 per year, P
AB - Multiple Sclerosis is more common in women than men and females have more relapses than men. In a large international cohort we have evaluated the effect of gender on disability accumulation and disease progression to determine if male MS patients have a worse clinical outcome than females.Using the MSBase Registry, data from 15,826 MS patients from 25 countries was analysed. Changes in the severity of MS (EDSS) were compared between sexes using a repeated measures analysis in generalised linear mixed models. Kaplan-Meier analysis was used to test for sex difference in the time to reach EDSS milestones 3 and 6 and the secondary progressive MS.In relapse onset MS patients (n = 14,453), males progressed significantly faster in their EDSS than females (0.133 vs 0.112 per year, P
U2 - 10.1371/journal.pone.0122686
DO - 10.1371/journal.pone.0122686
M3 - Article
SN - 1932-6203
VL - 10
JO - PLOS ONE
JF - PLOS ONE
IS - 6
M1 - e0122686
ER -