Abstract
Muscle wasting in old age or cancer may result from failed myofiber regeneration and/or accelerated atrophy. This study aimed to determine from transcriptomic analysis of human muscle the integrity of the cellular stress response system in relation to satellite cell differentiation or apoptosis in patients with cancer (weight-stable (CWS) or weight-losing (CWL)) or healthy elderly (HE) when compared with healthy middle-aged controls (HMA). 28 patients with cancer (CWS: 18 and CWL: 10), HE: 21 and HMA: 20 underwent biopsy of quadriceps muscle. The expression of transcription factors for muscle regeneration (Pax3, Pax7 and MyoD) was increased in CWS and HE compared with HMA (p
Original language | English |
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Pages (from-to) | 1690-1702 |
Journal | Aging |
Volume | 8 |
Issue number | 8 |
DOIs | |
Publication status | Published - Aug 2016 |
Keywords
- cachexia
- elderly
- satellite cells
- oxidative stress