TY - JOUR
T1 - Long-Term Quality of Life in Adult Survivors of Pediatric Differentiated Thyroid Carcinoma
AU - Nies, Marloes
AU - Hesselink, Marielle S. Klein
AU - Huizinga, Gea A.
AU - Sulkers, Esther
AU - Brouwers, Adrienne H.
AU - Burgerhof, Johannes G. M.
AU - van Dam, Eveline W. C. M.
AU - Havekes, Bas
AU - van den Heuvel-Eibrink, Marry M.
AU - Corssmit, Eleonora P. M.
AU - Kremer, Leontien C. M.
AU - Netea-Maier, Romana T.
AU - van der Pal, Heleen J. H.
AU - Peeters, Robin P.
AU - Plukker, John T. M.
AU - Ronckers, Cecile M.
AU - van Santen, Hanneke M.
AU - Tissing, Wim J. E.
AU - Links, Thera P.
AU - Bocca, Gianni
PY - 2017/4/1
Y1 - 2017/4/1
N2 - Context: Little is known about long-term quality of life (QoL) of survivors of pediatric differentiated thyroid carcinoma. Therefore, this study aimed to evaluate generic health-related QoL (HRQoL), fatigue, anxiety, and depression in these survivors compared with matched controls, and to evaluate thyroid cancer-specific HRQoL in survivors only.Design: Survivors diagnosed between 1970 and 2013 at ageResults: Sixty-seven survivors and 56 controls. Median age of survivors at evaluation was 34.2 years (range, 18.8 to 61.7). Median follow-up was 17.8 years (range, 5.0 to 44.7). On most QoL subscales, scores of survivors and controls did not differ significantly. However, survivors had more physical problems (P = 0.031), role limitations due to physical problems (P = 0.021), and mental fatigue (P = 0.016) than controls. Some thyroid cancer-specific complaints (e.g., sensory complaints and chilliness) were present in survivors. Unemployment and more extensive disease or treatment characteristics were most frequently associated with worse QoL.Conclusions: Overall, long-term QoL in survivors of pediatric DTC was normal. Survivors experienced mild impairment of QoL in some domains (physical problems, mental fatigue, and various thyroid cancer-specific complaints). Factors possibly affecting QoL need further exploration.
AB - Context: Little is known about long-term quality of life (QoL) of survivors of pediatric differentiated thyroid carcinoma. Therefore, this study aimed to evaluate generic health-related QoL (HRQoL), fatigue, anxiety, and depression in these survivors compared with matched controls, and to evaluate thyroid cancer-specific HRQoL in survivors only.Design: Survivors diagnosed between 1970 and 2013 at ageResults: Sixty-seven survivors and 56 controls. Median age of survivors at evaluation was 34.2 years (range, 18.8 to 61.7). Median follow-up was 17.8 years (range, 5.0 to 44.7). On most QoL subscales, scores of survivors and controls did not differ significantly. However, survivors had more physical problems (P = 0.031), role limitations due to physical problems (P = 0.021), and mental fatigue (P = 0.016) than controls. Some thyroid cancer-specific complaints (e.g., sensory complaints and chilliness) were present in survivors. Unemployment and more extensive disease or treatment characteristics were most frequently associated with worse QoL.Conclusions: Overall, long-term QoL in survivors of pediatric DTC was normal. Survivors experienced mild impairment of QoL in some domains (physical problems, mental fatigue, and various thyroid cancer-specific complaints). Factors possibly affecting QoL need further exploration.
KW - DEPRESSION SCALE HADS
KW - CANCER SURVIVORS
KW - CHILDHOOD-CANCER
KW - PROFILES REGISTRY
KW - HOSPITAL ANXIETY
KW - HEALTH SURVEY
KW - FATIGUE
KW - ADOLESCENTS
KW - DUTCH
KW - VALIDATION
U2 - 10.1210/jc.2016-2246
DO - 10.1210/jc.2016-2246
M3 - Article
C2 - 28001468
SN - 0021-972X
VL - 102
SP - 1218
EP - 1226
JO - Journal of Clinical Endocrinology & Metabolism
JF - Journal of Clinical Endocrinology & Metabolism
IS - 4
ER -