TY - JOUR
T1 - Long-Term Impact of Endometrial Cancer Diagnosis and Treatment on Health-Related Quality of Life and Cancer Survivorship: Results From the Randomized PORTEC-2 Trial
AU - de Boer, Stephanie M.
AU - Nout, Remi A.
AU - Jurgenliemk-Schulz, Ina M.
AU - Jobsen, Jan J.
AU - Lutgens, Ludy C. H. W.
AU - van der Steen-Banasik, Elzbieta M.
AU - Mens, Jan Willem M.
AU - Slot, Annerie
AU - Kroese, Marika C. Stenfert
AU - Oerlemans, Simone
AU - Putter, Hein
AU - Verhoeven-Adema, Karen W.
AU - Nijman, Hans W.
AU - Creutzberg, Carien L.
PY - 2015/11/15
Y1 - 2015/11/15
N2 - Purpose: To evaluate the long-term health-related quality of life (HRQL) after external beam radiation therapy (EBRT) or vaginal brachytherapy (VBT) among PORTEC-2 trial patients, evaluate long-term bowel and bladder symptoms, and assess the impact of cancer on these endometrial cancer (EC) survivors. Patients and Methods: In the PORTEC-2 trial, 427 patients with stage I high-intermediate-risk EC were randomly allocated to EBRT or VBT. The 7- and 10-year HRQL questionnaires consisted of EORTC QLQ-C30; subscales for bowel and bladder symptoms; the Impact of Cancer Questionnaire; and 14 questions on comorbidities, walking aids, and incontinence pads. Analysis was done using linear mixed models for subscales and (ordinal) logistic regression with random effects for single items. A two-sided P value
AB - Purpose: To evaluate the long-term health-related quality of life (HRQL) after external beam radiation therapy (EBRT) or vaginal brachytherapy (VBT) among PORTEC-2 trial patients, evaluate long-term bowel and bladder symptoms, and assess the impact of cancer on these endometrial cancer (EC) survivors. Patients and Methods: In the PORTEC-2 trial, 427 patients with stage I high-intermediate-risk EC were randomly allocated to EBRT or VBT. The 7- and 10-year HRQL questionnaires consisted of EORTC QLQ-C30; subscales for bowel and bladder symptoms; the Impact of Cancer Questionnaire; and 14 questions on comorbidities, walking aids, and incontinence pads. Analysis was done using linear mixed models for subscales and (ordinal) logistic regression with random effects for single items. A two-sided P value
U2 - 10.1016/j.ijrobp.2015.08.023
DO - 10.1016/j.ijrobp.2015.08.023
M3 - Article
C2 - 26530748
SN - 0360-3016
VL - 93
SP - 797
EP - 809
JO - International Journal of Radiation Oncology Biology Physics
JF - International Journal of Radiation Oncology Biology Physics
IS - 4
ER -