Long-term effects of prenatal allopurinol treatment on brain plasticity markers in low and normal birth weight piglets

Jos Prickaerts; Elise T. Gieling; Ann K. Bruder; Franz J. van der Staay; Tim Vanmierlo

doi:10.1016/j.ijdevneu.2013.11.001

Long-term effects of prenatal allopurinol treatment on brain plasticity markers in low and normal birth weight piglets

Jos Prickaerts, Elise T. Gieling, Ann K. Bruder, Franz J. van der Staay, Tim Vanmierlo^*

^*Corresponding author for this work

MHeNs - Neuroscience

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

In this study, we investigated the effect of antenatal allopurinol (ALLO) treatment on levels and expression of plasticity markers in the dorsal hippocampus of low (LBW) and normal (NBW) birth weight piglets. ALLO treatment given daily in the last trimester to pregnant sows had a protective effect on neuronal plasticity markers in their piglets. ALLO increases protein levels of BDNF and the postsynaptic marker PSD95 in LBW and NBW piglets. ALLO treatment increases the pCREB/CREB ratio in LBW piglets to a similar level as that found in untreated NBW piglets. In conclusion, antioxidant treatment administered in the last trimester might be a promising treatment for LBW neonates.

Original language	English
Pages (from-to)	29-32
Journal	International Journal of Developmental Neuroscience
Volume	33
DOIs	https://doi.org/10.1016/j.ijdevneu.2013.11.001
Publication status	Published - Apr 2014

Keywords

Allopurinol
Low birth weight
BDNF
Neuronal plasticity
Pig

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10.1016/j.ijdevneu.2013.11.001

Cite this

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title = "Long-term effects of prenatal allopurinol treatment on brain plasticity markers in low and normal birth weight piglets",

abstract = "In this study, we investigated the effect of antenatal allopurinol (ALLO) treatment on levels and expression of plasticity markers in the dorsal hippocampus of low (LBW) and normal (NBW) birth weight piglets. ALLO treatment given daily in the last trimester to pregnant sows had a protective effect on neuronal plasticity markers in their piglets. ALLO increases protein levels of BDNF and the postsynaptic marker PSD95 in LBW and NBW piglets. ALLO treatment increases the pCREB/CREB ratio in LBW piglets to a similar level as that found in untreated NBW piglets. In conclusion, antioxidant treatment administered in the last trimester might be a promising treatment for LBW neonates. ",

keywords = "Allopurinol, Low birth weight, BDNF, Neuronal plasticity, Pig",

author = "Jos Prickaerts and Gieling, {Elise T.} and Bruder, {Ann K.} and {van der Staay}, {Franz J.} and Tim Vanmierlo",

year = "2014",

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doi = "10.1016/j.ijdevneu.2013.11.001",

language = "English",

volume = "33",

pages = "29--32",

journal = "International Journal of Developmental Neuroscience",

issn = "0736-5748",

publisher = "Elsevier Science",

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TY - JOUR

T1 - Long-term effects of prenatal allopurinol treatment on brain plasticity markers in low and normal birth weight piglets

AU - Prickaerts, Jos

AU - Gieling, Elise T.

AU - Bruder, Ann K.

AU - van der Staay, Franz J.

AU - Vanmierlo, Tim

PY - 2014/4

Y1 - 2014/4

N2 - In this study, we investigated the effect of antenatal allopurinol (ALLO) treatment on levels and expression of plasticity markers in the dorsal hippocampus of low (LBW) and normal (NBW) birth weight piglets. ALLO treatment given daily in the last trimester to pregnant sows had a protective effect on neuronal plasticity markers in their piglets. ALLO increases protein levels of BDNF and the postsynaptic marker PSD95 in LBW and NBW piglets. ALLO treatment increases the pCREB/CREB ratio in LBW piglets to a similar level as that found in untreated NBW piglets. In conclusion, antioxidant treatment administered in the last trimester might be a promising treatment for LBW neonates.

AB - In this study, we investigated the effect of antenatal allopurinol (ALLO) treatment on levels and expression of plasticity markers in the dorsal hippocampus of low (LBW) and normal (NBW) birth weight piglets. ALLO treatment given daily in the last trimester to pregnant sows had a protective effect on neuronal plasticity markers in their piglets. ALLO increases protein levels of BDNF and the postsynaptic marker PSD95 in LBW and NBW piglets. ALLO treatment increases the pCREB/CREB ratio in LBW piglets to a similar level as that found in untreated NBW piglets. In conclusion, antioxidant treatment administered in the last trimester might be a promising treatment for LBW neonates.

KW - Allopurinol

KW - Low birth weight

KW - BDNF

KW - Neuronal plasticity

KW - Pig

U2 - 10.1016/j.ijdevneu.2013.11.001

DO - 10.1016/j.ijdevneu.2013.11.001

M3 - Article

C2 - 24291206

SN - 0736-5748

VL - 33

SP - 29

EP - 32

JO - International Journal of Developmental Neuroscience

JF - International Journal of Developmental Neuroscience

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